Navigation Links
Freezing breast tumors helps stop cancer’s spread in mice, U-M study finds

ANN ARBOR, Mich. Freezing a cancer kills it in its place, and also appears to generate an immune response that helps stop the cancer's spread, leading to improved survival rates over surgery, according to a new study in mice from researchers at the University of Michigan Comprehensive Cancer Center.

Researchers looked at two different cryoablation techniques, which both involve applying a cold probe to a tumor to freeze it. The study was done in mice with breast cancer. One method involves freezing the tumor rapidly, in about 30 seconds; the other freezes the tumor slowly, taking a few minutes. Results from the cryoablation were compared to results from mice whose tumors were removed with surgery.

Both cryoablation techniques successfully killed the breast tumor. The mice treated with the rapid freeze had fewer tumors that spread to the lungs and improved survival compared to mice treated with surgery alone or mice treated with the slower freezing technique. The study showed that the benefit from the rapid freezing is likely due to changes in the immune system that help to kill the tumor. Freezing with the slower technique appeared to make the immune system not as able to kill the tumor.

The study appears online in Annals of Surgical Oncology. Based on these results from mice, researchers are now conducting a clinical trial using cryoablation in patients with breast cancer. In this trial, researchers use the rapid freezing technique.

"Cryoablation has strong potential as a treatment for breast cancer. Not only does it appear effective in treating the primary tumor with little cosmetic concerns, but it also may stimulate an immune response capable of eradicating any cells that have traveled throughout the body, reducing both local and distant recurrence, similar to giving a breast cancer vaccine," says lead study author Michael Sabel, M.D., associate professor of surgery at the U-M Medical School.

"What we learned in this study is that all cryoablation is not equal. The technique used to freeze the tissue can have a significant impact on how the immune system responds. The system we use today appears to be ideal for both destroying the tumor within the breast and generating an anti-cancer immune response," Sabel says.

U-M researchers are participating in a national clinical trial to evaluate using cryoablation for early stage breast cancer. Participants will undergo rapid freezing of their tumor, and their blood samples will be analyzed to assess changes in their immune system. All participants will be treated three to four weeks later with standard surgery to remove their tumor.


Contact: Nicole Fawcett
University of Michigan Health System

Related medicine news :

1. At last! A Remarkable Breakthrough for Parkinson's Disease Freezing: The GaitAid Virtual Walker
2. Advanced Bag Design for Cryopreservation: The New CryoMACS(R) Freezing Bag
3. Freezing Kidney Cancers Shows Promise
4. Freezing Ovaries Preserves Fertility, Scientists Report
5. Tissue-Freezing Technique Effective Against Prostate Cancer
6. Pacific Fertility Center Announces Breakthrough in Egg Freezing Technology
7. Common osteoporosis drugs are associated with a decrease in risk of breast cancer
8. Breast Cancer Charity Website Offers Breast Cancer Profiler Tool
9. PINC trial launched to test new treatment for pre-invasive breast cancer
10. How estrogen feeds breast tumors
11. A primer on aspirating breast lumps
Post Your Comments:
(Date:12/1/2015)... ... 01, 2015 , ... Physicians’ Education Resource®, LLC (PER®) ... announced that the first annual School of Gastrointestinal Oncology™ (SOGO™) will be held ... treatment of gastrointestinal cancers are undergoing transformational change, providing oncologists with powerful new ...
(Date:12/1/2015)... ... December 01, 2015 , ... Speech and ... believe that with innovative technologies and under the right circumstances, these practices can ... benefit of a dual-approach to his or her therapeutic sessions, as well as ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... the 7th Annual 2015 Golden Bridge Business Awards under the New Products and ... zero capex web based sample management software that helps labs organize ...
(Date:12/1/2015)... ... December 01, 2015 , ... The importance of volumetric ... the focus of numerous abstracts accepted for presentation here, at the 101st Annual ... abstracts highlight the use of Volpara Solutions’ quantitative breast imaging software tools for ...
(Date:12/1/2015)... ... December 01, 2015 , ... SAN FRANCISCO, Calif. ... that the organization has awarded Education and Developmental Therapies (EDT), an Applied Behavior ... award celebrates exceptional special needs providers that excel in synthesizing the areas of ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... Russia has always been a country of choice for ... Europe in 2015 were tested in phase II-III ... has always been a country of choice for global multi-center phase ... in 2015 were tested in phase II-III clinical trials ... always been a country of choice for global multi-center phase III clinical ...
(Date:12/1/2015)... ANGELES , Dec. 1, 2015 CytRx ... development company specializing in oncology, today announced that it ... the company,s pivotal global Phase 3 clinical trial of ... (STS). Enrollment was originally estimated to be completed in Q1 ... being conducted under a Special Protocol Assessment from the ...
(Date:12/1/2015)... , Dec. 1, 2015  The migration to ... develop shared care plans that help patients stay ... plans will be digitally enabled, incorporate care guidelines ... and desires. They will also allow all stakeholders ... health journey is optimal. That is the vision, ...
Breaking Medicine Technology: