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Freezing Wrinkles a Possible Alternative to Botox
Date:4/2/2011

fining the technique and could not say how long the effect lasts, but it seems to be comparable to Botox, which works for about three to four months, Palmer said.

Physicians would need training to identify the nerve that should be targeted, he added.

The 15-minute treatment is done using local anesthesia, according to the researchers. The current study only looks at forehead wrinkles; future research will study the procedure elsewhere on the face, Palmer said.

For the study, researchers tried the technique on 31 people, all of whom had fewer wrinkles after two to eight injections. The most common side effects were headaches and skin redness. The level of discomfort was comparable to that from Botox or fillers, Palmer said.

But unlike Botox, which takes a few days to kick in, the effects of the cryotechnology are seen immediately, the researchers say.

Because this study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

Palmer said he didn't see the new technology as a replacement for Botox, but instead as an alternative for people who don't want an injection of a neurotoxin.

The company will eventually seek FDA approval as a medical device. Palmer said the company might first seek approval in Europe.

Dr. Brian Zelickson, an associate professor of dermatology at the University of Minnesota in Minneapolis, said the technique sounds promising, but needs more research to determine how long results last and to make sure no lasting nerve or muscle injury occurs that could cause permanent changes in sensation.

He agreed that the toxin-free cosmetic procedure might win some followers.

"Botox and Dysport are very easy, very quick, the patient satisfaction profile is great and there are very few side effects," said Zelickson, incoming president of ASLMS. "It's a high bar to leap over, but there are some people that don't like t
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