Should this line of work prove successful, existing tissue banks could be refitted to create a nationwide supply of therapeutically enhanced tendons for transplant, according to the study authors. Millions of bone and cartilage grafts are already used in orthopaedics, as well as in plastic and general surgery. The banks are made possible by conscientious donors that indicate in their wills, or on their licenses, that their tissue is to be donated upon their death.
Along with Awad, study authors were Patrick Basile, M.D., Tulin Dadali, B.S., Justin Jacobson, M.D., Yasuhiko Nishio, Ph.D., M. Hicham Drissi, Ph.D., Howard Langstein, M.D., David Mitten, M.D., Regis J OKeefe, M.D., Ph.D., and Edward Schwarz, Ph.D. from the University of Rochester Medical Center as well as Sys Hasslund, Michael Ulrich-Vinther and Kjeld Sballe from Aarhus University Hospital in Denmark. The team will next seek to determine the mechanisms by which growth factors repair tendons. After that, studies will move into larger animals and humans, potentially within a few years.
Tendon is very durable, said Regis OKeefe, M.D., Ph.D., chair of the Department of Orthopaedics and Rehabilitation at the University of Rochester Medical Center, and a study author. It could conceivably be
freeze-dried, thawed and then freeze-dried again without damaging it. It could be l
|Contact: Greg Williams|
University of Rochester Medical Center