Navigation Links
Freeze-dried tendon implants prove effective in early studies
Date:1/8/2008

Donated, freeze-dried tendon grafts loaded with gene therapy may soon offer effective repair of injured tendons, a goal that has eluded surgeons to date. According to study data published today in the journal Molecular Therapy, a new graft technique may provide the first effective framework around which flexor tendon tissue can reorganize as it heals. Such tissue-engineering approaches could significantly improve repair of anterior cruciate ligaments and rotator cuffs as well, researchers said. The study was in a mouse model designed to resemble hard-to-repair flexor tendons in human hands, and the results should provide an impetus for future clinical trials.

Tendons are elastic cords that anchor muscle to bone and enable flexing muscle to move limbs. Related injuries represent nearly half of 33 million U.S. orthopaedic injuries each year, and a frequent cause of emergency room visits. In many standard repair attempts, surgeons implant an autograft, a piece of tendon from elsewhere in the same patient. Along with requiring patients to sacrifice tendon, the problem with live autografts is that both the graft and the graft site know they have been injured. That signals immune cells and chemicals to rush into the graft site, seeking to fight infection. Unfortunately, those same processes cause inflammation and scarring, which in turn cause implanted tendon to stick to the joint. To work properly, the tendon must be free to glide across the joint. Tendon adhesions, a longstanding post-surgical problem, cause pain and permanently limit range of motion.

Researchers next experimented with allografts: tendons donated from one person to another. Clinically, this technique fared worse than autografts because patients bodies would recognize the donated tendon as foreign, attempt to wall it off with fibrous proteins and in some cases reject the transplant. The field then looked at whether synthetic scaffolds made of gel or fiber mesh could serve as alte
'/>"/>

Contact: Greg Williams
Greg_Williams@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3 4 5

Related medicine news :

1. Saline Wash May Ease Shoulder Tendonitis
2. Ultrasound-guided injections help ease chronic Achilles tendon pain
3. USC researcher identifies stem cells in tendons that regenerate tissue in animal model
4. ASPS Studies Re-Evaluate Psychological Benefits and Health Concerns of Silicone Breast Implants
5. Neural Insights Could Bring Better Cochlear Implants
6. Advertisements for Medical Devices, Implants Should Carry Warnings of Dangerous Side Effects, Infections
7. BioHorizons Introduces Its New Tapered Internal Implants Featuring Laser-Lok(R) Microgrooves
8. Little Evidence Silicone Breast Implants Harm Health
9. TyRx Pharma, Inc. Announces Presentation of Results to Benefit Women with Breast Implants (In-Vivo Efficacy Study Regarding AIGISRx DEB) at the Plastic Surgery 2007 Meeting on October, 28 2007 in Baltimore, MD
10. Bone-growing nanomaterial could improve orthopaedic implants
11. Nanowire coating for bone implants, stents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2013)... June 20, 2013 Millions of Britons ... serious medical conditions because they do not brush their ... and Elgydium toothpaste. , Seven million Britons do not ... hours between brushes, latest data from the British Dental ... people polled by the BDHF also admitted that they ...
(Date:6/20/2013)... June 20, 2013 Startups who need ... their sales or test new markets, and international companies ... have a new sales outsourcing company to ... revenue. , Strategy Sales Partners is a ... by business owners for business owners, Strategy Sales Partners ...
(Date:6/19/2013)... Santiago, Chile (PRWEB) June 20, 2013 ... Chile Montaña has put together their winter season ... of outdoor adventure day trips in and around Santiago ... lead trips into Chile's Central Andes for backcountry skiing, ... , For those who have always dreamed of ...
(Date:6/19/2013)... 2013 Shreya Rangarajan of Roland Park ... summit on the future of medicine. , Today, ... Youth Summit on the Future of Medicine and has ... and the state of Maryland at the Summit. , ... in an environment hard to imagine just a few ...
(Date:6/19/2013)... Author Byron Oberst draws on his experiences as a pediatric ... body’s defense mechanisms work in his colorful new book ... by Trafford Publishing). , Ideal for children 2 – 7, ... Bobbie, a little boy who wakes up with a sore ... visit Doctor Getwell, who prescribes antibiotics and reminds Bobbie to ...
Breaking Medicine News(10 mins):Health News:Millions Are Risking Gum Disease, Warn Eludril And Elgydium 2Health News:Millions Are Risking Gum Disease, Warn Eludril And Elgydium 3Health News:Strategy Sales Partners Launches to Provide Sales Outsourcing Assistance to Businesses 2Health News:Strategy Sales Partners Launches to Provide Sales Outsourcing Assistance to Businesses 3Health News:Chile Montaña Announces Winter Season Santiago Day Trips 2Health News:Chile Montaña Announces Winter Season Santiago Day Trips 3Health News:Global Youth Summit on The Future of Medicine-Shreya Rangarajan selected to represent Roland Park Country School and The State of Maryland 2Health News:Global Youth Summit on The Future of Medicine-Shreya Rangarajan selected to represent Roland Park Country School and The State of Maryland 3Health News:New Book Shows Children How the Body Fights Germs 2
... his research, he begins with the dramatic story of Mariana ... sepsis in January after amputation of both her hands and ... a fellow in allergy, pulmonary and critical care medicine, is ... come up with a high-tech approach to combat this deadly ...
... Host Interviews CPF Co-Founder, PF Advocate, and Top PF Researcher and ... for Pulmonary Fibrosis (CPF) today announced its co-founder and other Pulmonary ... Satellite Radio Show "Doctor Radio" on Tuesday, June 16th from 6-7 ... can be heard via a free pass available on the Internet. ...
... Companion Animal Parasite Council heads West, driving home the importance ... , BEL AIR, Md., June 15 Temperate climates, ... make the Western United States an ideal location for the ... Show, June 27 - July 11. , , During ...
... colon cancer may be safer for some older patients, ... Screening colonoscopies for colon cancer may be too risky ... Of all the screening methods for colon cancer, a ... only finds, but also removes, cancerous and precancerous lesions. ...
... open their doors to expose young women to careers in ... June 15 Victoria Horsley is like most ... school. Though for her, learning the intricacies of the human ... Northwestern Memorial Hospital,s Bluhm Cardiovascular Institute will rank high along ...
... Complications may include wound infections, heart problems, new ... -- Severely obese people undergoing surgery are at ... hospital stays and other complications, according to a ... Yet many cardiologists, surgeons, anesthesiologists and other health-care ...
Cached Medicine News:Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 2Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 3Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 4Health News:Vanderbilt researchers pioneer an advanced sepsis detection and management system 5Health News:CPF, Pulmonary Fibrosis Experts Guests on Sirius and XM Satellite Radio Show June 16th 2Health News:Nonprofit Goes RVing to Promote Pet and Human Health 2Health News:Nonprofit Goes RVing to Promote Pet and Human Health 3Health News:Colonoscopy Risks Increase With Age and Illness 2Health News:Colonoscopy Risks Increase With Age and Illness 3Health News:Teens as Cardiologists in Training: Program Swaps Backpacks for Stethoscopes 2Health News:Teens as Cardiologists in Training: Program Swaps Backpacks for Stethoscopes 3Health News:Teens as Cardiologists in Training: Program Swaps Backpacks for Stethoscopes 4Health News:Heart Association Warns of Surgery Risks in Obese 2
(Date:6/19/2013)... , June 19, 2013 DST Health ... and services to health plans, integrated delivery systems, and ... Medical Drug Management Service (MDMS) has jumped ... edit and automate the pricing of medical prescription drug ... efficiencies by automating their medical drug claims processes. As ...
(Date:6/19/2013)... PRINCETON, N.J. , June 19, 2013 ... Belrose Pharma, a new specialty pharmaceutical company ... generation of innovative injectable and sustained release ... high unmet medical needs, today announced the ... (Customized Linker Technology®) platform and associated product ...
(Date:6/19/2013)... June 19, 2013 Pharma IQ is ... infographic summary of the results from an industry survey ... all respondents stated that CROs would be an area of ... will be running 6 or more clinical trials in the ... Trial Supply USA Summit explores the ...
Breaking Medicine Technology:Demand For DST's Medical Drug Management Service On The Rise As Health Plan Costs Increase 2Demand For DST's Medical Drug Management Service On The Rise As Health Plan Costs Increase 3Belrose Pharma Acquires Enzon's Advanced Drug Formulation Technology and Clinical Assets as Foundation for Driving Development of More Effective Injectable and Sustained Release Therapies 2Belrose Pharma Acquires Enzon's Advanced Drug Formulation Technology and Clinical Assets as Foundation for Driving Development of More Effective Injectable and Sustained Release Therapies 3Belrose Pharma Acquires Enzon's Advanced Drug Formulation Technology and Clinical Assets as Foundation for Driving Development of More Effective Injectable and Sustained Release Therapies 4Pharma IQ Presents the Latest Trends in Clinical Trial Supply 2
... revolutionary INSORB Subcuticular Skin Stapler is designed ... sutures with the rapid closure times associated ... need for metal staple removal post-operatively., ,The ... sterile, single patient use device that deploys ...
... A disposable lever action skin ... head that is designed to ... your work from your normal ... are available in four configurations: ...
... Focus from Thermo Labsystems was ... with uncompromising performance. The ... a custom fit for different ... tip cones allow easier and ...
... and value!, Comfortable feel and ... contoured handle , Finer control while ... action , Completely autoclavable for easy ... for recalibration , Easy-to-read precision micrometer ...
Medicine Products: