Navigation Links
Freeslate Featured in BioProcess International Article Discussing Challenges and Solutions to Highly Concentrated Protein Formulations

Sunnyvale, CA (PRWEB) July 24, 2014

Freeslate, Inc., the leading provider of high throughput research solutions for biopharmaceutical development, today announced its feature in the BioProcess International article “Highly Concentrated Protein Formulations” by Jim Kling. Topics of this article include problematic issues with highly concentrated protein formulations and how automation can help address many of these problems.

High-concentration protein formulations have been a growing focus of pharmaceutical organizations in recent years. For example, these drug formulations would allow patients to perform injections themselves, instead of scheduling an inconvenient trip to the doctor each time an intravenous infusion treatment is needed.

However, protein aggregates, which can reduce potency or sometimes spur an immune-system response, have a higher likelihood of forming when higher concentrations are present. Formulations with high concentrations also are inclined to be more viscous, which can cause interference with the plunging motion of a prefilled syringe.

Issues like these require pharmaceutical companies to run hundreds of tests to find a solution. Problems with formulations normally do not cause a drug development program to fail. However, these issues can add valuable time and expenses to a program, sometimes limiting formulation applications for new drugs.

Automation can help reduce the impact of these time and expense impacts. For instance, one can use a small amount of material for testing, allowing one to test more formulations from a given batch. “It used to be that formulators would pick four formulations or so to move forward with,” said Dr. Russell Burge, Applications Scientist at Freeslate and contributor to the article. “But now with the high-concentration formulations, more testing may be necessary to ensure that the formulation in the final product is safe and effective, and more testing could also be necessary.”

Freeslate’s Biologics Formulation System allows pharmaceutical firms to develop more candidates, with more robust formulations, in a shorter period of time, with less material, and no increase in personnel. Freeslate has developed a single system that can support the entire formulation development process by combining liquid dispense and controlled heating/cooling/mixing with the introduction of new high throughput capabilities for pH measurement, viscosity measurement, and visual inspection/particle counting. Combined with Freeslate Lab Execution and Analysis (LEA) software, the Biologics Formulation System provides intuitive experiment design and allows for the control and data integration for a range of third party analytics including DLS, UV/Vis, cIEF, cSDS, HPLC, UPLC, etc. maximizing your R&D productivity.

Additional information on this article can be found by visiting the Bioprocess International website.

About Freeslate

Freeslate is a privately held company providing laboratory automation products that dramatically improve the productivity and innovation of drug development organizations. For more than a decade, Freeslate has been working with customers to automate complex chemical research processes. Our resulting product line includes solutions for protein and vaccine drug formulation development, small molecule solubility, and polymorph screening and process chemistry. We start with a scientific understanding of our customer’s bottlenecks and utilize our robust and proprietary automation platforms and integrated Lab Execution and Analysis (LEA) software suite to deliver solutions that make a difference. The company is headquartered in Sunnyvale, California, with direct sales and service in North America, Europe, and Asia. For more information, visit

Read the full story at

Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related medicine news :

1. Freeslate Launches New CM Protégé Bioformulation Assessment Systems, Automating Visible Particle Detection, pH, and Viscosity Measurements
2. Model for breast cancer rehab featured in supplement to ACS journal, Cancer
3. Vendors in Nevada, Michigan, & Illinois to be Featured on the Online Network
4. Dr. Edmund Lipskis & Dr. Lynn Lipskis Will be Featured On New National Television Show Entitled: “Leading The Field” World Class Experts Share Their Tips & Advice
5. New York Stem Cell Foundation scientists featured for new model of Alzheimers disease
6. Advances in ataxia research to be featured at USFs Innovative Learning and Simulation Center
7. Mary Newswanger, from, was Recently Nationally Featured on ABC, NBC, Fox, & LA Daily News Regarding Planet Friendly Technologies
8. As Nationally Featured on CBS Money Watch, Celebrity Doctor Anna Guarna, Is to Co-Author a New Business Book, "Leading the Field"
9. Attorney Deborah Truhowsky Featured On “Paying It Forward” Internet Broadcast Program
10. Marketing Xocolate International Corp (MXI Corp) Makers of Xocai Healthy Dark Chocolate, Featured in Direct Selling News Spotlighting the Company's Continued Growth
11. Allen Kesselring, Ph.D. of EAG Life Sciences Featured in Special Report on Extractables and Leachables
Post Your Comments:
(Date:11/27/2015)... VVA (PRWEB) , ... November 27, 2015 , ... ... motto of progress through sharing, the 2016 Building Better Radiology Marketing ... The conference will begin on Sunday, March 6, 2016, at Caesars Palace in ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... failing. Secura Consultants has prided itself for not only fulfilling the needs of ... protection solutions at an affordable price and providing top-tier customer service. However, there's ...
(Date:11/27/2015)... ... 2015 , ... The men and women on this list ... the country. They have overseen financial turnarounds, shown commitment to their community through ... as a whole through their advocacy and professional efforts. , Becker's Hospital Review ...
(Date:11/27/2015)... ... 2015 , ... Indosoft Inc., developer and distributor of the ... LTS (Long Term Support) into its Q-Suite 5.10 product line. , Making the ... a version of Asterisk that will receive not only security fixes, but feature ...
(Date:11/26/2015)... ... November 26, 2015 , ... CognisantMD and Cambridge Memorial ... in the Waterloo region. Using the Ocean Platform, family physicians can now order ... electronic medical record (EMR) without the need for redundant patient entry or an ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015  Linden Care, LLC, a retail specialty pharmacy ... patients suffering from chronic pain, said today that it ... Order (TRO) enjoining Express Scripts from unilaterally terminating the ... --> --> The company said ... options. --> --> ...
(Date:11/25/2015)... 25, 2015 On Tuesday, November 24, ... trial against Wright Medical Technology, Inc. for product ... metal-on-metal hip implant device, awarded $11 million in ... week trial and three days of deliberations, the ... was defectively designed and unreasonably dangerous, and that ...
(Date:11/25/2015)... 25, 2015  Henry Schein, Inc., the world,s largest ... dental, medical and animal health practitioners, will unveil at ... Henry Schein ConnectDental® Pavilion , which brings together for ... solutions designed to help any practice or laboratory enter ... for a schedule of experts appearing at the Pavilion. ...
Breaking Medicine Technology: