Navigation Links
Freeslate Featured in BioProcess International Article Discussing Challenges and Solutions to Highly Concentrated Protein Formulations

Sunnyvale, CA (PRWEB) July 24, 2014

Freeslate, Inc., the leading provider of high throughput research solutions for biopharmaceutical development, today announced its feature in the BioProcess International article “Highly Concentrated Protein Formulations” by Jim Kling. Topics of this article include problematic issues with highly concentrated protein formulations and how automation can help address many of these problems.

High-concentration protein formulations have been a growing focus of pharmaceutical organizations in recent years. For example, these drug formulations would allow patients to perform injections themselves, instead of scheduling an inconvenient trip to the doctor each time an intravenous infusion treatment is needed.

However, protein aggregates, which can reduce potency or sometimes spur an immune-system response, have a higher likelihood of forming when higher concentrations are present. Formulations with high concentrations also are inclined to be more viscous, which can cause interference with the plunging motion of a prefilled syringe.

Issues like these require pharmaceutical companies to run hundreds of tests to find a solution. Problems with formulations normally do not cause a drug development program to fail. However, these issues can add valuable time and expenses to a program, sometimes limiting formulation applications for new drugs.

Automation can help reduce the impact of these time and expense impacts. For instance, one can use a small amount of material for testing, allowing one to test more formulations from a given batch. “It used to be that formulators would pick four formulations or so to move forward with,” said Dr. Russell Burge, Applications Scientist at Freeslate and contributor to the article. “But now with the high-concentration formulations, more testing may be necessary to ensure that the formulation in the final product is safe and effective, and more testing could also be necessary.”

Freeslate’s Biologics Formulation System allows pharmaceutical firms to develop more candidates, with more robust formulations, in a shorter period of time, with less material, and no increase in personnel. Freeslate has developed a single system that can support the entire formulation development process by combining liquid dispense and controlled heating/cooling/mixing with the introduction of new high throughput capabilities for pH measurement, viscosity measurement, and visual inspection/particle counting. Combined with Freeslate Lab Execution and Analysis (LEA) software, the Biologics Formulation System provides intuitive experiment design and allows for the control and data integration for a range of third party analytics including DLS, UV/Vis, cIEF, cSDS, HPLC, UPLC, etc. maximizing your R&D productivity.

Additional information on this article can be found by visiting the Bioprocess International website.

About Freeslate

Freeslate is a privately held company providing laboratory automation products that dramatically improve the productivity and innovation of drug development organizations. For more than a decade, Freeslate has been working with customers to automate complex chemical research processes. Our resulting product line includes solutions for protein and vaccine drug formulation development, small molecule solubility, and polymorph screening and process chemistry. We start with a scientific understanding of our customer’s bottlenecks and utilize our robust and proprietary automation platforms and integrated Lab Execution and Analysis (LEA) software suite to deliver solutions that make a difference. The company is headquartered in Sunnyvale, California, with direct sales and service in North America, Europe, and Asia. For more information, visit

Read the full story at

Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related medicine news :

1. Freeslate Launches New CM Protégé Bioformulation Assessment Systems, Automating Visible Particle Detection, pH, and Viscosity Measurements
2. Model for breast cancer rehab featured in supplement to ACS journal, Cancer
3. Vendors in Nevada, Michigan, & Illinois to be Featured on the Online Network
4. Dr. Edmund Lipskis & Dr. Lynn Lipskis Will be Featured On New National Television Show Entitled: “Leading The Field” World Class Experts Share Their Tips & Advice
5. New York Stem Cell Foundation scientists featured for new model of Alzheimers disease
6. Advances in ataxia research to be featured at USFs Innovative Learning and Simulation Center
7. Mary Newswanger, from, was Recently Nationally Featured on ABC, NBC, Fox, & LA Daily News Regarding Planet Friendly Technologies
8. As Nationally Featured on CBS Money Watch, Celebrity Doctor Anna Guarna, Is to Co-Author a New Business Book, "Leading the Field"
9. Attorney Deborah Truhowsky Featured On “Paying It Forward” Internet Broadcast Program
10. Marketing Xocolate International Corp (MXI Corp) Makers of Xocai Healthy Dark Chocolate, Featured in Direct Selling News Spotlighting the Company's Continued Growth
11. Allen Kesselring, Ph.D. of EAG Life Sciences Featured in Special Report on Extractables and Leachables
Post Your Comments:
(Date:11/27/2015)... Los Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... the conversation at the recent 2015 American Dental Association meeting in Washington D.C. revolved ... can help protect a patient’s overall health. The talk stressed the link between periodontal ...
(Date:11/27/2015)... ... November 27, 2015 , ... The rapid speed at ... people age, more care is needed, especially with Alzheimer’s, dementia and other cognitive ... being overworked. The forgotten part of this equation: 80 percent of medical care ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... the toilets were," said an inventor from Hillside, N.J. "Many people catch diseases ... cover so that individuals will always be protected from germs." , He developed ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ProSidebar: Fashion ... Final Cut Pro X. With ProSidebar: Fasion, video editors can easily add an ... as a minimalist title opener. Utilize presets featuring self-animating drop zones, lines, bars, ...
(Date:11/27/2015)... ... November 27, 2015 , ... Intellitec Solutions announced ... User Group (MSDSLUG). Recognized as Microsoft’s official group for end users of Dynamics ... software users, partners, industry experts and representatives. Intellitec Solutions’ membership status demonstrates their ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Une nouvelle approche consistant ... contre le cancer avancé.    --> ... au traitement photodynamique au Bremachlorin contre le cancer ... nouvelle approche consistant à combiner l,immunothérapie au traitement ...    Clinical Cancer Research . ...
(Date:11/27/2015)... -- --> --> ... potential to save costs, improve treatment quality and accelerate ... exploited as yet. Here, particular emphasis is placed on ... tablet or directly at the patients, bedside. ... -->      (Photo: ) ...
(Date:11/27/2015)... November 27, 2015 Ein ... fortgeschrittenem Krebs.   --> Ein neuer ... Krebs.   --> Ein neuer ... Krebs.   Clinical Cancer Research ... Clinical Cancer Research vom 6. November 2015 ...
Breaking Medicine Technology: