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Freeslate Featured in BioProcess International Article Discussing Challenges and Solutions to Highly Concentrated Protein Formulations
Date:7/24/2014

Sunnyvale, CA (PRWEB) July 24, 2014

Freeslate, Inc., the leading provider of high throughput research solutions for biopharmaceutical development, today announced its feature in the BioProcess International article “Highly Concentrated Protein Formulations” by Jim Kling. Topics of this article include problematic issues with highly concentrated protein formulations and how automation can help address many of these problems.

High-concentration protein formulations have been a growing focus of pharmaceutical organizations in recent years. For example, these drug formulations would allow patients to perform injections themselves, instead of scheduling an inconvenient trip to the doctor each time an intravenous infusion treatment is needed.

However, protein aggregates, which can reduce potency or sometimes spur an immune-system response, have a higher likelihood of forming when higher concentrations are present. Formulations with high concentrations also are inclined to be more viscous, which can cause interference with the plunging motion of a prefilled syringe.

Issues like these require pharmaceutical companies to run hundreds of tests to find a solution. Problems with formulations normally do not cause a drug development program to fail. However, these issues can add valuable time and expenses to a program, sometimes limiting formulation applications for new drugs.

Automation can help reduce the impact of these time and expense impacts. For instance, one can use a small amount of material for testing, allowing one to test more formulations from a given batch. “It used to be that formulators would pick four formulations or so to move forward with,” said Dr. Russell Burge, Applications Scientist at Fre
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