Navigation Links
Free radicals may be good for you
Date:2/28/2011

Fear of free radicals may be exaggerated, according to scientists from the Swedish medical university Karolinska Institutet. A new study, published in the Journal of Physiology, shows that free radicals act as signal substances that cause the heart to beat with the correct force.

Free radicals are molecules that react readily with other substances in the body, and this can have negative effects on health in certain circumstances, through the damage caused to cells. Free radicals can be counteracted by substances known as 'antioxidants', which are common ingredients in many dietary supplements. The idea that free radicals are generally dangerous and must be counteracted is, however, a myth, according to scientists who have conducted a new study of the role that free radicals play in heart physiology.

"As usual, it's a case of everything in moderation. In normal conditions, free radicals act as important signal substances, but very high levels or long-lasting increases can lead to disease", says Professor Hkan Westerblad, who has led the study.

When the body is subject to different types of stress, the sympathetic nervous system stimulates receptors known as beta-adrenergic receptors on the surface of heart muscle cells. This leads to several changes inside the cells, one of which is the phosphorylation of proteins. This leads to the contractions of the cells becoming stronger and the heart beats with greater force.

In the current study, the scientists show that stimulation of the beta-adrenergic receptors also leads to increased production of free radicals in the mitochondria of the cells, and these then contribute to stronger contractions of the cells. When the scientists exposed the cells to antioxidants, a major part of the effect of beta-adrenergic stimulation of the heart muscle cells disappeared.

The results reveal a previously unknown regulatory mechanism of the force production in the heart, and may lead to a better understanding of various types of heart deficiency.

"Free radicals play an important role, since they contribute to the heart being able to pump more blood in stress-filled situations", says Hkan Westerblad. "On the other hand, persistent stress can lead to heart failure, and chronically increased levels of free radicals may be part of the problem here."


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Plant compound resveratrol shown to suppresses inflammation, free radicals in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, ... work on several important health care topics including advance care planning, healthcare costs ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of ... AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... HILL, N.C. , June 24, 2016 /PRNewswire/ ... healthcare decisions and regulators/payers have placed more emphasis ... new environment, patient support programs in the pharmaceutical ... for patients, medications. Consequently, pharmaceutical companies are focusing ... ensure they are providing products and services that ...
(Date:6/24/2016)... Dublin ... of the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global ... including its applications in various applications. The report deals ... three main industries: pharmaceutical and biotechnology, food and beverage, ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, ... -based mobile pulmonary function testing company, is now able to perform ... developed by ndd Medical Technologies , Inc. ... in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL ... can get any needed testing done in the comfort of her ...
Breaking Medicine Technology: