Navigation Links
Fred Hutchinson Cancer Research Center to co-lead 1 of 5 NCI-funded proteomics research centers
Date:8/22/2011

SEATTLE The National Cancer Institute today announced that a team co-led by Fred Hutchinson Cancer Research Center and The Broad Institute in Cambridge, Mass., has been selected to participate in a National Cancer Institute-funded research consortium dedicated to understanding the molecular basis of cancer . The researchers will aim to identify and analyze proteins in the blood that are associated with genetic alterations that lead to cancer. The overarching goal of the Clinical Proteomic Tumor Analysis Consortium, or CPTAC, is to improve the ability to prevent, diagnose and treat cancer.

The Hutchinson Center/Broad-led team will receive approximately $9 million in federal funding over three years with the possibility of an additional two years of funding pending scientific review mid-program.

Co-principal investigators of the Hutchinson Center/Broad team are Amanda Paulovich, M.D., Ph.D., an associate member of the Hutchinson Center's Clinical Research Division, and Steven Carr, Ph.D., director of Proteomics at the Broad Institute of MIT and Harvard. Their group is among five NCI-funded Proteome Characterization Centers nationwide that will work to define the interplay of genes and proteins on cancer development and prognosis.

This is not the first time the Paulovich and Carr laboratories have collaborated; in 2006 they, along with Leigh Anderson, Ph.D., founder and CEO of the Plasma Proteome Institute in Washington, D.C., were selected to co-lead one of five teams that received NCI funding during the first phase of the consortium, which was launched with the goal of improving success rates for developing new blood tests for cancer.

Understanding the body's protein landscape is important because proteins are the workhorses of the cell that carry out genetic instructions. Changes in the structure or abundance of proteins are associated with genetic mutations that cause diseases such as cancer.

Ultimately, the "holy grail" of proteomics the large-scale study of proteins is the discovery of protein biomarkers that could be used to create reliable and inexpensive blood tests to identify the onset and risk of a wide range of cancers and other diseases so they could be prevented or treated at the earliest possible stage, when cure rates are highest.

For the project, Paulovich, Carr and colleagues will continue their work, which harnesses a highly sensitive and targeted analytical technology multiple reaction monitoring mass spectrometry to develop assays, or tests, to measure levels of proteins found in cancer cells and patient blood. Unlike traditional mass spectrometry, which attempts to detect all proteins in a biological sample in a scattershot fashion, this technology is highly targeted, allowing researchers to calibrate the equipment to specifically look for peptides, or protein fragments, of interest, filtering out the rest as white noise.

Papers detailing the use of these technologies were published back-to-back by the Paulovich and Carr laboratories in the June 2011 issue of Nature Biotechnology.

During the second phase of consortium funding, Paulovich, Carr and colleagues throughout the network will use data and biospecimens from The Cancer Genome Atlas, or TCGA, a collaborative effort by NCI and the National Human Genome Research Institute. The CPTAC network will use proteomics to analyze cancer tissues that have also been characterized at the gene level by TCGA. The genomic and proteomic data will be combined to study the biology of the tumors, as well as to identify potential new diagnostic tests for cancer.

The other Proteome Characterization Centers are based at Pacific Northwest National Laboratory in Richland, Wash.; the University of North Carolina in Chapel Hill and Boise State University in Idaho; Johns Hopkins University in Baltimore; and Vanderbilt University in Nashville.


'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Related medicine news :

1. Hutchinson Center receives $8.2M to coordinate obesity and cancer consortium
2. Shanghai CDC and Hutchinson Center establish Shanghai Breast Health Resource Center
3. Fred Hutchinson Cancer Research Center to lead Immunotherapy Clinical Trials Network
4. NCI awards $11.5 million to Fred Hutchinson Cancer Research Center to lead breast cancer consortium
5. Fred Hutchinson Cancer Research Center scientist receives Presidential Early Career Award
6. Hutchinson Center and China CDC sign agreement for research and training collaboration
7. Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research
8. 17 percent of cancer nurses unintentionally exposed to chemotherapy, U-M study finds
9. The ignored virus that causes liver cancer
10. Radioembolization improves chance of survival for liver cancer patients
11. Saffron shows promise in preventing liver cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... 23, 2017 , ... A recent report from the National Council on Teacher ... NCTQ report suggests, based on a review of GPA and SAT/ACT requirements at 221 ... the U.S. It argues that this higher bar should be set by states, by ...
(Date:3/23/2017)... ... March 23, 2017 , ... Texas Physical Therapy ... 960 Gruene Road in Building 2. The clinic is the group’s second in New ... says opening the company’s second New Braunfels location brings things full circle for the ...
(Date:3/23/2017)... ... , ... The MBI “Hall of Fame” recognizes the contributions of those whose careers are or ... the careers of all others involved. , On Monday, March 21st, 2017 Laurie ... of Fame. The induction took place during the World of Modular – Award Gala ...
(Date:3/23/2017)... TX (PRWEB) , ... March 23, 2017 , ... March ... organs that pack a punch when it comes to maintaining good health. Every day, ... 30 minutes, your kidneys filter every drop of your blood, eliminating waste, regulating fluid ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... Angeles based healthcare technology company California Healthcom Group (CHG). , The HUG ... healthcare arena. With headquarters in California, CHG is a growing, internationally recognized healthcare ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)...  The U.S. Food and Drug Administration today granted ... adults and pediatric patients 12 years and older with ... not received prior chemotherapy. This is the first FDA-approved ... skin cancer. "While skin cancer is one ... form called Merkel cell cancer have not had an ...
(Date:3/23/2017)... AUSTIN, Texas , March 23, 2017 /PRNewswire/ ... www.digitalpharmacist.com ), a rapidly growing digital ... PocketRx, a mobile app that allows patients to ... including multi-store locations such as Denver Health Pharmacy, ... app. The acquisition helps Digital Pharmacist accelerate its ...
(Date:3/23/2017)... , March 23, 2017  Interpace Diagnostics Group, ... a fully integrated commercial company that provides clinically ... announced that it has entered into agreements to ... RedPath Shareholders ("RedPath") and concurrently terminate its royalty ... outstanding secured debt to RedPath amounting to $9.34 ...
Breaking Medicine Technology: