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Fred Hutchinson Cancer Research Center to co-lead 1 of 5 NCI-funded proteomics research centers
Date:8/22/2011

SEATTLE The National Cancer Institute today announced that a team co-led by Fred Hutchinson Cancer Research Center and The Broad Institute in Cambridge, Mass., has been selected to participate in a National Cancer Institute-funded research consortium dedicated to understanding the molecular basis of cancer . The researchers will aim to identify and analyze proteins in the blood that are associated with genetic alterations that lead to cancer. The overarching goal of the Clinical Proteomic Tumor Analysis Consortium, or CPTAC, is to improve the ability to prevent, diagnose and treat cancer.

The Hutchinson Center/Broad-led team will receive approximately $9 million in federal funding over three years with the possibility of an additional two years of funding pending scientific review mid-program.

Co-principal investigators of the Hutchinson Center/Broad team are Amanda Paulovich, M.D., Ph.D., an associate member of the Hutchinson Center's Clinical Research Division, and Steven Carr, Ph.D., director of Proteomics at the Broad Institute of MIT and Harvard. Their group is among five NCI-funded Proteome Characterization Centers nationwide that will work to define the interplay of genes and proteins on cancer development and prognosis.

This is not the first time the Paulovich and Carr laboratories have collaborated; in 2006 they, along with Leigh Anderson, Ph.D., founder and CEO of the Plasma Proteome Institute in Washington, D.C., were selected to co-lead one of five teams that received NCI funding during the first phase of the consortium, which was launched with the goal of improving success rates for developing new blood tests for cancer.

Understanding the body's protein landscape is important because proteins are the workhorses of the cell that carry out genetic instructions. Changes in the structure or abundance of proteins are associated with genetic mutations that cause diseases such as cancer.

Ultimately, the "holy grail
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Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

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