Navigation Links
Fred Hutchinson Cancer Research Center to co-lead 1 of 5 NCI-funded proteomics research centers

SEATTLE The National Cancer Institute today announced that a team co-led by Fred Hutchinson Cancer Research Center and The Broad Institute in Cambridge, Mass., has been selected to participate in a National Cancer Institute-funded research consortium dedicated to understanding the molecular basis of cancer . The researchers will aim to identify and analyze proteins in the blood that are associated with genetic alterations that lead to cancer. The overarching goal of the Clinical Proteomic Tumor Analysis Consortium, or CPTAC, is to improve the ability to prevent, diagnose and treat cancer.

The Hutchinson Center/Broad-led team will receive approximately $9 million in federal funding over three years with the possibility of an additional two years of funding pending scientific review mid-program.

Co-principal investigators of the Hutchinson Center/Broad team are Amanda Paulovich, M.D., Ph.D., an associate member of the Hutchinson Center's Clinical Research Division, and Steven Carr, Ph.D., director of Proteomics at the Broad Institute of MIT and Harvard. Their group is among five NCI-funded Proteome Characterization Centers nationwide that will work to define the interplay of genes and proteins on cancer development and prognosis.

This is not the first time the Paulovich and Carr laboratories have collaborated; in 2006 they, along with Leigh Anderson, Ph.D., founder and CEO of the Plasma Proteome Institute in Washington, D.C., were selected to co-lead one of five teams that received NCI funding during the first phase of the consortium, which was launched with the goal of improving success rates for developing new blood tests for cancer.

Understanding the body's protein landscape is important because proteins are the workhorses of the cell that carry out genetic instructions. Changes in the structure or abundance of proteins are associated with genetic mutations that cause diseases such as cancer.

Ultimately, the "holy grail" of proteomics the large-scale study of proteins is the discovery of protein biomarkers that could be used to create reliable and inexpensive blood tests to identify the onset and risk of a wide range of cancers and other diseases so they could be prevented or treated at the earliest possible stage, when cure rates are highest.

For the project, Paulovich, Carr and colleagues will continue their work, which harnesses a highly sensitive and targeted analytical technology multiple reaction monitoring mass spectrometry to develop assays, or tests, to measure levels of proteins found in cancer cells and patient blood. Unlike traditional mass spectrometry, which attempts to detect all proteins in a biological sample in a scattershot fashion, this technology is highly targeted, allowing researchers to calibrate the equipment to specifically look for peptides, or protein fragments, of interest, filtering out the rest as white noise.

Papers detailing the use of these technologies were published back-to-back by the Paulovich and Carr laboratories in the June 2011 issue of Nature Biotechnology.

During the second phase of consortium funding, Paulovich, Carr and colleagues throughout the network will use data and biospecimens from The Cancer Genome Atlas, or TCGA, a collaborative effort by NCI and the National Human Genome Research Institute. The CPTAC network will use proteomics to analyze cancer tissues that have also been characterized at the gene level by TCGA. The genomic and proteomic data will be combined to study the biology of the tumors, as well as to identify potential new diagnostic tests for cancer.

The other Proteome Characterization Centers are based at Pacific Northwest National Laboratory in Richland, Wash.; the University of North Carolina in Chapel Hill and Boise State University in Idaho; Johns Hopkins University in Baltimore; and Vanderbilt University in Nashville.


Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center

Related medicine news :

1. Hutchinson Center receives $8.2M to coordinate obesity and cancer consortium
2. Shanghai CDC and Hutchinson Center establish Shanghai Breast Health Resource Center
3. Fred Hutchinson Cancer Research Center to lead Immunotherapy Clinical Trials Network
4. NCI awards $11.5 million to Fred Hutchinson Cancer Research Center to lead breast cancer consortium
5. Fred Hutchinson Cancer Research Center scientist receives Presidential Early Career Award
6. Hutchinson Center and China CDC sign agreement for research and training collaboration
7. Hutchinson Center receives $10.24 million from NIH for Latina breast cancer research
8. 17 percent of cancer nurses unintentionally exposed to chemotherapy, U-M study finds
9. The ignored virus that causes liver cancer
10. Radioembolization improves chance of survival for liver cancer patients
11. Saffron shows promise in preventing liver cancer
Post Your Comments:
(Date:12/1/2015)... ... 02, 2015 , ... Ruth Pearson was struggling. She had been laid off ... assistance and quickly losing hope of recovering her former life, Pearson was desperate for ... attending a women’s retreat when she experienced a particularly impactful worship service. Without help ...
(Date:12/1/2015)... ... December 01, 2015 , ... On Tuesday ... to NASDAQ to educate the personnel on spinal decompression therapy and offer his ... a nonsurgical procedure. The benefits come from creating negative intradiscal pressure which is ...
(Date:12/1/2015)... ... December 01, 2015 , ... Henderson, a ... to receive Gigabit Internet through a partnership this year with Aeneas Internet and ... is an attractive destination for entrepreneurs who want to build a business. Whether ...
(Date:12/1/2015)... ... , ... Florida Hospital Tampa is the first health care provider in the region ... , vBloc® Therapy is a vagal blocking therapy, delivered via the Maestro® System, for the ... (BMI) of at least 40 to 45 kg, or a BMI of at least 35 ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... Califia ... today announced that its iconic bottle has won top honors in Beverage World Magazine’s ... The Company also announced that it has been selected as a 2015 U.S.A. Taste ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... --> --> ... by Type of Drug (Monoclonal Antibodies, Interferon-Alpha, Interleukins, Vaccines, (Therapeutic ... Analysis - Global Forecast to 2020", published by MarketsandMarkets, the ... Million by 2020 from USD 40,281.6 Million in 2015, at ... Browse 37 market data T ...
(Date:12/1/2015)... 2015 Assurex Health, Inc. today announced ... healthcare providers an expanded range of options in ... from depression, anxiety, bipolar disorder, posttraumatic stress disorder ... i .   --> ... addition of two new drug classes, 17 FDA-approved ...
(Date:12/1/2015)... , Dec. 1, 2015  Six months of adjunctive metformin ... type 1 diabetes, according to new research from T1D ... it may have a beneficial effect on measures of obesity, ... issue of the Journal of the American Medical Association ... the effect of metformin on overweight and obese adolescents with ...
Breaking Medicine Technology: