Navigation Links
Fragile period of childhood brain development could underlie epilepsy
Date:8/23/2009

BOSTON A form of partial epilepsy associated with auditory and other sensory hallucinations has been linked to the disruption of brain development during early childhood, according to a study led by researchers at Beth Israel Deaconess Medical Center (BIDMC).

Described in today's Advance On-line issue of Nature Medicine, these new findings provide the first genetic link between childhood brain development and a seizure disorder that lasts throughout adulthood, and also identify a new pathway that controls how neuron circuits are "pruned" and matured.

"During early childhood roughly between the ages of one and five the brain undergoes a period of major circuit remodeling," explains senior author Matthew Anderson, MD, PhD, a principal investigator in the Departments of Neurology and Pathology at BIDMC. "Our discovery that a familial form of temporal lobe epilepsy can develop at this point demonstrates the fragility of the brain during this critical period."

The new findings focus on the development of synapses, the connections between brain cells.

"At birth, the brain is loaded with excitatory synapses which help make nerve cells 'fire,'" explains Anderson, who is also an Assistant Professor of Neurology and Pathology at Harvard Medical School. "However, if these excess synapses are not adequately 'pruned,' they can overgrow, leading to excessive transmission of excitatory signals and the development of pathological conditions, including learning disabilities and autism in addition to epilepsy."

Using a genetically engineered mouse model created in his laboratory, together with brain slice patch-clamp electrophysiology techniques, Anderson and his scientific team found that a mutant form of the LGI1 (leucine-rich glioma-inactivated 1) gene was preventing the normal brain development.

"The first clue was our discovery that LGI1 is not expressed until the exact time when excitatory synapses are matured
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. $21.8 Million NIH Grant for Fragile X Research
2. Stem cell research produces a key discovery for Fragile X Syndrome
3. Brain Defect Helps Drive Fragile X Syndrome
4. Fragile X Foundations Sign Merger Agreement
5. Fragile X Syndrome Corrected in Mice
6. Drosophila drug screen for fragile X syndrome finds promising compounds and potential drug targets
7. The Area's Most Fragile Babies Have a New Home
8. The Most Fragile Babies in the Nations Capital Have a New Home
9. Earlier Testing Needed for Fragile X Syndrome
10. NIH Plan Charts Course to Better Treatments and Cure for Most Common Known Genetic Cause of Autism: Fragile X
11. Microtek Medical Receives Early Termination of Hart-Scott-Rodino Act Waiting Period for Its Proposed Acquisition by Ecolab
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... Texas (PRWEB) September 21, 2014 ... (FDA) in 1996, GSK’s Flovent (fluticasone propionate) is ... It is used for the maintenance treatment of ... now available in two formulations, Diskus and HFA, ... 2004, respectively. Flovent’s active ingredient, fluticasone propionate, can ...
(Date:9/21/2014)... 21, 2014 High in the rugged ... disabled and able-bodied athletes rafted the Colorado River, rode ... course in pursuit of outdoor adventure. At the September ... World T.E.A.M. Sports, disabilities proved to be no more ... the three stage event. , Each participating team of ...
(Date:9/21/2014)... IL (PRWEB) September 21, 2014 “Cluster ... is so intense and difficult to resolve,” said Steve ... I can't think of a pain that is more ... who suffers from cluster headaches, or migraines, that medical ... on the serotonin system,” he added. , Serotonin (5-HT, ...
(Date:9/21/2014)... Faculty and staff at Garrison Forest School (GFS), ... Mills, Md., kicked off the academic year by taking a ... the first independent school to receive the bands— which calculate ... patterns— as part of a pilot program with Charm ... chain. The Vivofit bands are just one tool in a ...
(Date:9/21/2014)... 21, 2014 Top10BestSEOHosting.com, a leading ... ) and GreenGeeks are the most recommended hosting ... buy high quality hosting products. , “Don’t ... suppliers; we recommend two great hosting companies to ... believe that iPage and GreenGeeks are the most ...
Breaking Medicine News(10 mins):Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 2Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 3Health News:Flovent Asthma Market Sales & SWOT Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 4Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 2Health News:Disabled Athletes Excel at World T.E.A.M. Sports’ Adventure Team Challenge 3Health News:Homeostasis: Equinox Serotonin (5HT) Headache Stories ~ New on the Bryan William Brickner Blog 2Health News:Garrison Forest School Leader in Independent School Wellness Programs 2Health News:Leading Review Website Top10BestSEOHosting.com Unveils The Best Hosting Suppliers In September 2
... and Maureen Neitz, the husband-and-wife team whose pioneering research may ... disorders, as the inaugural recipients of the Jay Pepose ,75 ... a $1 million endowment established this year through a gift ... ,74, his wife. The endowment primarily supports graduate research fellowships ...
... ... Hospital Inc. (Rutherfordton, N.C.), a management client since 1983, and Sturgis Hospital (Sturgis, ... Providers by Cleverley + Associates. , ... Brentwood, Tenn. (PRWEB) December 17, 2009 -- Quorum ...
... ... is pleased to announce its newly redesigned Web site: www.psanj.com . PSANJ is a ... as New York magazine and New Jersey Monthly. , ... New Brunswick, NJ (PRWEB) December 17, 2009 -- Plastic Surgery Arts ...
... ... underscore the important role that competent, educated CT technologists play in minimizing dose ... ... (Vocus) December 16, 2009 -- Two recent studies examining radiation doses delivered during ...
... It,s customary for the holidays to wreak havoc on healthy habits. ... short-changed and nutrition is left to chance. But according to ... the holidays without throwing wellbeing out the window. That,s why California ... to make wise choices during the holiday season and get a ...
... MIAMI, Dec. 17 Physicians Healthcare Management Group, Inc. ... it has issued its financial statements for the nine months ... on the Pink Sheets (www.pinksheets.com). , About ... Management Group, Inc. (Phyhealth) is a developer of community-based health ...
Cached Medicine News:Health News:Vision researchers Jay and Maureen Neitz to receive first Pepose Award from Brandeis 2Health News:QHR Client Hospitals in North Carolina, Michigan Lauded for Providing Community Value 2Health News:Plastic Surgery Arts of New Jersey (PSANJ) Launches New Web Site 2Health News:Plastic Surgery Arts of New Jersey (PSANJ) Launches New Web Site 3Health News:ASRT Supports Efforts to Minimize CT Radiation Dose 2Health News:ASRT Supports Efforts to Minimize CT Radiation Dose 3Health News:ASRT Supports Efforts to Minimize CT Radiation Dose 4Health News:Celebrity Fitness Trainer Valerie Waters and California Raisins Offer Advice on How to Jump Start the New You in the New Year 2Health News:Celebrity Fitness Trainer Valerie Waters and California Raisins Offer Advice on How to Jump Start the New You in the New Year 3Health News:Phyhealth Issues September 30, 2009 Financial Statements 2
(Date:9/19/2014)... Sept. 19, 2014 Harwood Feffer LLP ( ... of directors of PDL BioPharma, Inc. ("PDL" or the ... board has breached its fiduciary duties to shareholders or ... 16, 2014, the Company disclosed: "On September 11, 2014, ... firm, Ernst & Young LLP ("EY"), that it was ...
(Date:9/19/2014)... "Copay coupons," a drug manufacturer ... drugs among patients with prescription drug coverage, may now be ... report  from the Department of Health and ... anti-kickback laws prohibit suppliers from offering side-payments to ... the federal government. The report ...
(Date:9/19/2014)... , Sept. 19, 2014 Today, iHealth Lab ... from Xiaomi Ventures, Ltd. for its first institutional round ... continue expanding iHealth,s global reach, accelerate growth and innovation, ... part of the investment, Xiaomi Ventures will join iHealth,s ... of cloud infrastructure and ecommerce. "We are ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of PDL BioPharma, Inc. 2PCMA: New OIG Report Cites Drug Manufacturer "Copay Coupon" Use in Medicare Part D 2iHealth Raises $25 Million to Fuel Growth and Global Market Share 2
... LAKE, N.J. , May 10 Par Pharmaceutical ... its partner, Glenmark Generics Limited and Glenmark Generics Inc., ... & Co. Inc. that resolves patent litigation related to Glenmark,s ... ends the lawsuit involving a challenge by Glenmark which sought ...
... , May 10 /PRNewswire-Asia/ -- On April ... cases with Beijing Un-Assegai Technical &,Trade Co. Ltd. (hereinafter referred ... China , as claimant and U.S. Abbott,Laboratories (Abbott U.S.; ... by the,China International Economic and Trade Arbitration Commission (CIETAC), which,has ...
Cached Medicine Technology:Par's Development and Marketing Partner, Glenmark, Enters Into A Settlement Agreement With Merck To Settle Patent Litigation Over Generic ZETIA(R) 2Assegai Wins Big Settlement Against ABBOTT's Subsidiary 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: