Navigation Links
Fragile X syndrome protein linked to breast cancer progression

Claudia Bagni (VIB/KU Leuven, Belgium, and the University of Rome Tor Vergata, Italy), has identified the way Fragile X Mental Retardation Protein or FMRP contributes to the progression of breast cancer. For this research the group of Bagni collaborated with colleagues from the VIB/KU Leuven departments of Bart De Strooper and Peter Carmeliet (VIB/KU Leuven), with Patrick Neven (UZ Leuven) and with several research centers and Hospitals in Italy and the UK. The researchers demonstrated that FMRP acts as a master switch controlling the levels of several proteins involved in different stages of aggressive breast cancer, including the invasion of cancer cells into blood vessels and the spread of these cancer cells to other tissues forming metastasis. The work is published on-line in EMBO Molecular Medicine.

Claudia Bagni: "Breast cancer is the most common form of cancer in women. It often comes back years after treatment and spreads throughout the body. We here show a correlation between the FMRP level in breast tissue and the chance of the spread of cancer to other organs. I hope that we can use this knowledge to develop a test to predict the likelihood of metastasis."

The authors identified high levels of FMRP in human breast cancer tissue microarrays and also examined the effects of FMRP levels in a mouse model to study breast cancer. In these mice, high levels of FMRP in primary breast cancer tumors were also linked to the spread of the cancer to the lungs and the development of metastasis. Importantly, reduction of FMRP, on the contrary lead to a decrease of metastasis formation and protection against breast cancer in individuals lacking this protein.

The role of FMRP is well known in the brain, where its absence leads to Fragile X Syn-drome, the most prevalent form of inherited intellectual disability in humans. The present study explored the direct relationship between the levels of FMRP and the progression of breast cancer.

"Previous studies indicated that patients with Fragile X Syndrome had a decreased risk of developing cancer but little is known about the molecular events that lead to this beneficial effect. We showed that high levels of the FMRP protein in human breast tissue samples are linked to increased risk of breast cancer and the spread of the disease to other tissues throughout the body," EMBO Member Claudia Bagni from VIB/KU Leuven, Belgium/ University of Rome Tor Vergata, Italy, who led the study, remarked. "Our results suggest that FMRP acts as a master regulator of a large group of mRNAs that are involved in multiple steps of cancer progression".

The researchers suggest that the levels of FMRP might be used as an indicator of aggressive breast cancer and could be used to predict the likelihood of the spread of cancer to other organs like the lung. In fact, the authors found that FMRP levels correlate with the highly aggressive Triple Negative Breast Cancer. Breast cancer is the most common form of cancer in women and has a poor prognosis. It often comes back years after treatment and spreads throughout the body.


Contact: Sooike Stoops
VIB (the Flanders Institute for Biotechnology)

Related medicine news :

1. MIND Institute researchers receive $1 million grant to study cognitive training in fragile X
2. Drug Shows Promise Against Fragile X Syndrome, Possibly Autism
3. Dr. Roger Reeves, 2012 Sisley-Jérôme Lejeune Prize Winner, Significantly Advances Understanding of the Biology of Down Syndrome Leading to New Avenues of Research
4. IBS Home Treatment
5. “IBS Miracle” Teaches People How to Get Rid of Their Irritable Bowel Syndrome (IBS) Symptoms Quickly – V kool
6. UCLA researchers describe new form of irritable bowel syndrome
7. Hot Line IV: Late-breaking trials on heart failure and acute coronary syndrome
8. Common blood pressure drug reduces aortic enlargement in Marfan syndrome
9. Transcranial direct current stimulation improves sleep in patients with post-polio syndrome
10. Dr. Donald Corenman, MD, Conducted a Two Year Study on the Effectiveness of Transforaminal Lumbar Interbody Fusion (TLIF) in Treating Discogenic Pain Syndrome (DPS)
11. No evidence of increased risk of Guillain-Barre syndrome following vaccination
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... Holcomb – Kreithen ... plastic surgery practices in Florida, is proud to announce that Dr. Joshua Kreithen, ... giant Ethicon Inc., a Johnson & Johnson Company. , Ethicon is a global ...
(Date:11/30/2015)... EMIGSVILLE, PA (PRWEB) , ... November 30, 2015 ... ... (CCMS) software provider, has verified that their Vasont Universal Integrator (VUI) extension unites ... handle creating, editing, and managing content as a continuous process with the latest ...
(Date:11/30/2015)... Maryland (PRWEB) , ... November 30, 2015 , ... ... interactions could be of critical importance to the medical schools of the future. ... exhibited its healthcare suite at the 2015 ChangeMedEd conference in Chicago, organized by ...
(Date:11/30/2015)... ... 30, 2015 , ... Innovaacom, a leading provider of medical ... survey of educational needs for pharmacists worldwide. The poll of pharmacists in Europe, ... quality online and face-to-face education for pharmacists who are fast becoming the new ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... In 2016, expected coding changes are likely to include new codes for spine ... not easy to understand the effects of code changes in musculoskeletal, radiology and ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... , Nov. 30, 2015 NHS Supply ... 20 TrueBeam™ machines from Varian Medical Systems (NYSE: ... program to replace older machines and institute modern ... UK,s public hospitals. The order, placed in September, ... licenses for Varian,s RapidArc® and Eclipse™ software systems.    ...
(Date:11/30/2015)... , Nov. 30, 2015  Hanger, Inc. (NYSE: ... restatement of the terms of its previously announced consent ... to its $200,000,000 aggregate principal amount 7⅛% Senior Notes ... (i) the consent fees payable pursuant to the Consent ... Notes and (iii) the expiration date of the Consent ...
(Date:11/30/2015)... , Nov. 30, 2015  Precision Image ... services, is pleased to announce a dramatic expansion ... imaging services. Building on its ISO-9001:2008 certification for ... implemented comprehensive Core Lab protocols and procedures. This ... of research activities.  Their Core Lab services include ...
Breaking Medicine Technology: