Navigation Links
Fragile X syndrome protein linked to breast cancer progression
Date:9/18/2013

Claudia Bagni (VIB/KU Leuven, Belgium, and the University of Rome Tor Vergata, Italy), has identified the way Fragile X Mental Retardation Protein or FMRP contributes to the progression of breast cancer. For this research the group of Bagni collaborated with colleagues from the VIB/KU Leuven departments of Bart De Strooper and Peter Carmeliet (VIB/KU Leuven), with Patrick Neven (UZ Leuven) and with several research centers and Hospitals in Italy and the UK. The researchers demonstrated that FMRP acts as a master switch controlling the levels of several proteins involved in different stages of aggressive breast cancer, including the invasion of cancer cells into blood vessels and the spread of these cancer cells to other tissues forming metastasis. The work is published on-line in EMBO Molecular Medicine.

Claudia Bagni: "Breast cancer is the most common form of cancer in women. It often comes back years after treatment and spreads throughout the body. We here show a correlation between the FMRP level in breast tissue and the chance of the spread of cancer to other organs. I hope that we can use this knowledge to develop a test to predict the likelihood of metastasis."

The authors identified high levels of FMRP in human breast cancer tissue microarrays and also examined the effects of FMRP levels in a mouse model to study breast cancer. In these mice, high levels of FMRP in primary breast cancer tumors were also linked to the spread of the cancer to the lungs and the development of metastasis. Importantly, reduction of FMRP, on the contrary lead to a decrease of metastasis formation and protection against breast cancer in individuals lacking this protein.

The role of FMRP is well known in the brain, where its absence leads to Fragile X Syn-drome, the most prevalent form of inherited intellectual disability in humans. The present study explored the direct relationship between the levels of FMRP and the progression of breast cancer. '/>"/>

Contact: Sooike Stoops
info@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MIND Institute researchers receive $1 million grant to study cognitive training in fragile X
2. Drug Shows Promise Against Fragile X Syndrome, Possibly Autism
3. Dr. Roger Reeves, 2012 Sisley-Jérôme Lejeune Prize Winner, Significantly Advances Understanding of the Biology of Down Syndrome Leading to New Avenues of Research
4. IBS Home Treatment
5. “IBS Miracle” Teaches People How to Get Rid of Their Irritable Bowel Syndrome (IBS) Symptoms Quickly – V kool
6. UCLA researchers describe new form of irritable bowel syndrome
7. Hot Line IV: Late-breaking trials on heart failure and acute coronary syndrome
8. Common blood pressure drug reduces aortic enlargement in Marfan syndrome
9. Transcranial direct current stimulation improves sleep in patients with post-polio syndrome
10. Dr. Donald Corenman, MD, Conducted a Two Year Study on the Effectiveness of Transforaminal Lumbar Interbody Fusion (TLIF) in Treating Discogenic Pain Syndrome (DPS)
11. No evidence of increased risk of Guillain-Barre syndrome following vaccination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... 2014) Measuring the levels of sex hormones in patients, ... arrest, a heart rhythm disorder that is fatal in 95 ... by the peer-reviewed journal Heart Rhythm , shows that ... found in men who had a sudden cardiac arrest. Higher ... associated with greater chances of having a sudden cardiac arrest ...
(Date:9/2/2014)... 02, 2014 Anti-aging is proving ... services such as anti-wrinkle treatments and products, hair ... and breast augmentation becoming much sought after worldwide. ... market intelligence firm Transparency Market Research, the global ... grow to USD 191.7 billion by 2019, from ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 Last year, ... level with the launch of a luxurious line of graduated ... that the SEA ISLAND COTTON Socks are joining the SIGVARIS ... giving more people the comfort of natural cotton fibers. ... they are surprised to find socks as soft as the ...
(Date:9/2/2014)... 02, 2014 Alliance Strategies Group, LLC, ... email marketing is pleased to announce it is bringing ... & Freedom as well as The Red ... than one million concerned Americans who can be reached ... “We are honored to continue providing our clients and ...
(Date:9/2/2014)... you are hospitalized, but your outpatient doctor does ... office for follow-up care, but your doctor does ... stay? Missing or incomplete communication from hospitals ... to poor experiences and lead to hospital readmissions. ... implementing guidelines can improve hospitals, communication during patient ...
Breaking Medicine News(10 mins):Health News:Study links sex hormone levels in the blood to risk of sudden cardiac arrest 2Health News:Global Anti-aging Market Research Report 2018 by Transparency Market Research 2Health News:Global Anti-aging Market Research Report 2018 by Transparency Market Research 3Health News:SIGVARIS’ Luxury Line of Compression Socks, SEA ISLAND COTTON, Now Available in Stronger Compression Level 2Health News:ASG Continues to Bring New Lists to Market 2Health News:ASG Continues to Bring New Lists to Market 3Health News:Can data motivate hospital leaders to improve care transitions? 2
... people are turning to the Internet to find information, important ... sheer avalanche of facts// now available online. Key science sites ... results. ,New research funded by the Economic and ... Web to make their information available must now pay attention ...
... during the 85th General Session of the International ... reporting that they have developed an effective program ... an innovative school-based cavity prevention program, which provides ... exams, cleanings and preventive care. For children enrolled ...
... are non-carbonated and do not contain the acids that ... the March/April 2007 issue of General Dentistry. ... that the only concern is sugar content. Most choose ... diet drinks contain phosphoric acid and/or citric acid and ...
... A drug used to strengthen bone has been found to ... with Parkinson disease//, according to a study. ,The ... Tokyo, Japan. Half of the group received the drug risedronate ... D2. ,The study found the men taking ...
... of an epidemic if parents do not get their ... 119 lives in the state last year. ... get their wards immunized against Japanese encephalitis, the situation ... IANS. ,A massive vaccination program launched by ...
... center and cervical cancer screening program will be inaugurated Thursday ... of Tamil Nadu. ,Colposcopy is a diagnostic tool ... ,Pap smear is collection of cells from ... after George Papanicolaou an American anatomist. It is used ...
Cached Medicine News:Health News:Key Science Web Sites Buried in Information Avalanche 2Health News:Forsyth Scientists Wiping Out Tooth Decay Through School-based Cavities Prevention Program 2Health News:Scare in Assam Over Japanese Encephalitis Vaccine 2
(Date:9/2/2014)... 2, 2014   Santa Clara dentist , Dr. ... promotion for Invisalign. Invisalign is an orthodontic system that ... is often the orthodontic treatment of choice for older ... of it. For a limited time, patients can try ... from the usual cost. This offer cannot be combined, ...
(Date:9/2/2014)... Spain , September 2, 2014 ... at ESC CONGRESS 2014 provide insight into treatment ... in everyday clinical practice --   ... Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF), ... that stroke prevention strategies for atrial fibrillation (AF) ...
(Date:9/2/2014)... -- Ortho Development® Corporation (ODEV) has received FDA ... addition to its growing hip replacement product line. ... in total hip arthroplasty and hemiarthroplasty procedures. ... Alpine was developed based on the clinically-proven, ... closely with a select team of orthopedic surgeons ...
Breaking Medicine Technology:Santa Clara Cosmetic Dentist, Dr. Alan Frame, is Now Offering a Special on Invisalign 2Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 2Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 3Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 4Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 5Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 6Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 7Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 8Data From Global Atrial Fibrillation Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke 9Ortho Development Receives FDA Clearance for Alpine Hip Stem 2
... R.I., June 13, 2011 CVS Caremark Corporation (NYSE: ... executive vice president and chief financial officer of CVS ... the Jeffries 2011 Global Consumer Conference on June 22, ... AM EDT. (Logo: http://photos.prnewswire.com/prnh/20090226/NE75914LOGO ) ...
... Henry Schein, Inc., (NASDAQ: HSIC ), the ... practitioners, announced today that Stanley M. Bergman, Chairman ... the Company,s Executive Vice President and Chief Financial Officer, will ... is taking place at the Four Seasons Hotel in Chicago. ...
Cached Medicine Technology:CVS Caremark to Present at the Jefferies 2011 Global Consumer Conference 2Henry Schein to Present at the William Blair 31st Annual Growth Stock Conference 2
Precision that fits in the palm of your hand and measures down to 125 microns, the Pocket Pachymeter is about 8" X 4" x 2" and really does fit in a lab coat pocket or briefcase....
15 segment Vertical Prism Bar provides 1, 2, 3, 4, 5, 6, 8, 10, 12, 14, 16, 18, 20, 25, 30 PD (Note: 30 PD is on the bar). 4448 xx Combined Horizontal and Vertical Prism Bar....
High performance capabilities in a multipurpose generator blended cut modes provide flexibility through varying degrees of hemostasis. Choose one of three preset modes. provide flexibility through va...
... Hyfrecator has been the #1 product ... electrosurgery for over 60 years. Remote control ... sterile field and decrease procedural time. Dual ... output of the Hyfrecator, the second to ...
Medicine Products: