Navigation Links
Fragile X syndrome protein linked to breast cancer progression
Date:9/18/2013

Claudia Bagni (VIB/KU Leuven, Belgium, and the University of Rome Tor Vergata, Italy), has identified the way Fragile X Mental Retardation Protein or FMRP contributes to the progression of breast cancer. For this research the group of Bagni collaborated with colleagues from the VIB/KU Leuven departments of Bart De Strooper and Peter Carmeliet (VIB/KU Leuven), with Patrick Neven (UZ Leuven) and with several research centers and Hospitals in Italy and the UK. The researchers demonstrated that FMRP acts as a master switch controlling the levels of several proteins involved in different stages of aggressive breast cancer, including the invasion of cancer cells into blood vessels and the spread of these cancer cells to other tissues forming metastasis. The work is published on-line in EMBO Molecular Medicine.

Claudia Bagni: "Breast cancer is the most common form of cancer in women. It often comes back years after treatment and spreads throughout the body. We here show a correlation between the FMRP level in breast tissue and the chance of the spread of cancer to other organs. I hope that we can use this knowledge to develop a test to predict the likelihood of metastasis."

The authors identified high levels of FMRP in human breast cancer tissue microarrays and also examined the effects of FMRP levels in a mouse model to study breast cancer. In these mice, high levels of FMRP in primary breast cancer tumors were also linked to the spread of the cancer to the lungs and the development of metastasis. Importantly, reduction of FMRP, on the contrary lead to a decrease of metastasis formation and protection against breast cancer in individuals lacking this protein.

The role of FMRP is well known in the brain, where its absence leads to Fragile X Syn-drome, the most prevalent form of inherited intellectual disability in humans. The present study explored the direct relationship between the levels of FMRP and the progression of breast cancer. '/>"/>

Contact: Sooike Stoops
info@vib.be
32-924-46611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MIND Institute researchers receive $1 million grant to study cognitive training in fragile X
2. Drug Shows Promise Against Fragile X Syndrome, Possibly Autism
3. Dr. Roger Reeves, 2012 Sisley-Jérôme Lejeune Prize Winner, Significantly Advances Understanding of the Biology of Down Syndrome Leading to New Avenues of Research
4. IBS Home Treatment
5. “IBS Miracle” Teaches People How to Get Rid of Their Irritable Bowel Syndrome (IBS) Symptoms Quickly – V kool
6. UCLA researchers describe new form of irritable bowel syndrome
7. Hot Line IV: Late-breaking trials on heart failure and acute coronary syndrome
8. Common blood pressure drug reduces aortic enlargement in Marfan syndrome
9. Transcranial direct current stimulation improves sleep in patients with post-polio syndrome
10. Dr. Donald Corenman, MD, Conducted a Two Year Study on the Effectiveness of Transforaminal Lumbar Interbody Fusion (TLIF) in Treating Discogenic Pain Syndrome (DPS)
11. No evidence of increased risk of Guillain-Barre syndrome following vaccination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Fredericton, NB (PRWEB) October 01, 2014 Indosoft, ... software Q-Suite, announces that it has added support ... Both Sangoma and Indosoft have a history ... industry. Sangoma's patent-pending technology offers a significant benefit to ... with AMD that is now available to users of Q-Suite. ...
(Date:10/1/2014)... MI (PRWEB) October 01, 2014 To help ... wellness center , Cutler Integrative Medicine, is detailing several tips ... , According to Dr. Cutler, women should start ... quality time for yourself that will help ‘center’ yourself for ... of stress,” he says. , Other health and fitness ...
(Date:9/30/2014)... at the same time could stop them from becoming ... Cancer Research * today (Wednesday). , ... funded by MedImmune, the global biologics research and development ... combining the two treatments helped the immune system hunt ... the initial radiotherapy in mice with breast, skin and ...
(Date:9/30/2014)... News) -- There,s no genetic evidence that high levels ... new study says. Some previous research had suggested ... against type 2 diabetes, raising the possibility of a ... disease. In this study, British researchers investigated the ... on genes that control blood levels of vitamin D. ...
(Date:9/30/2014)... HealthDay Reporter TUESDAY, Sept. 30, 2014 ... put the brakes on motherhood. And for many young women, ... new research suggests. Women in their early 20s appear ... tough economic times. But, according to the new study, that ... 40s and beyond. The findings suggest that higher unemployment ...
Breaking Medicine News(10 mins):Health News:Indosoft Announces Q-Suite Support For Sangoma Lyra 2Health News:In Recognition of National Women’s Health and Fitness Day, Cutler Integrative Medicine Details Tips for Living a Healthier and Happier Life 2Health News:Immunotherapy could stop resistance to radiotherapy 2Health News:Gene Study Finds No Proof Vitamin D Guards Against Type 2 Diabetes 2Health News:Recessions May Thwart a Woman's Motherhood Plans Forever: Study 2Health News:Recessions May Thwart a Woman's Motherhood Plans Forever: Study 3
... criticized Advanced Cells Therapeutics, which provided stem cell therapy for ... better than conventional treatments and her illness has not improved. ... Bryson said, "I'm back to where I was before the ... hope it was going to work and it didn't. I ...
... Australians live longer but with more disabilities among the aged. While ... in 1988, more people are suffering disabilities later in life, according ... ,Life expectancy for non-Indigenous Australian men has increased by ... 2003 can expect to live up to 77 and women up ...
... of Punjab and Haryana - will soon have 20 condom ... ,The machines will be installed by the state AIDS ... operate, insure and refill these machines, an official spokesman said. ... men's toilets at various places. ,The points identified ...
... may result from the body overshooting as it tries ... suggests new research// from the University of Massachusetts Amherst ... to a different time zone, the researchers recommend advancing ... allowing the body’s clocks to remain coordinated. The work ...
... results of a Canadian study, a multivitamin pill should ... to reduce risks of having a child with birth ... possibility of a wide range of severe birth defects ... hydrocephalus, heart malformations, truncated or missing limbs, urinary-tract abnormalities ...
... have a deleterious effect on young, developing brains, according ... toddlers is linked to lower IQ scores later in ... problems like diabetes, high cholesterol and hypertension is a ... professor of pediatric genetics at the University of Florida ...
Cached Medicine News:Health News:Model of Internal Clocks Reveals How Jet Lag Disrupts the System 2Health News:Model of Internal Clocks Reveals How Jet Lag Disrupts the System 3Health News:Prenatal multivitamins reduce birth defects 2Health News:Prenatal multivitamins reduce birth defects 3Health News:IQ of Toddlers Affected by Excess weight 2
(Date:9/30/2014)... , September 30, 2014 ... report the "Glycobiology/Glycomics Market by Product [Enzymes (Glycosyltransferase, ... Kits, and Reagents], Application (Immunology, Oncology) & ... 2019", published by MarketsandMarkets, provides a detailed ... opportunities, current market trends, and strategies impacting ...
(Date:9/30/2014)... ANGELES , Sept. 30, 2014   Easy ... shopping destination , today announced that it now offers ... . AirSense CPAPs are the first sleep apnea therapy ... it simple and easy to track and share real-time ... overall effectiveness of their CPAP therapy.  In addition, the ...
(Date:9/30/2014)... , Sept. 30, 2014 The Chinese ... ageing population and rise in the incidence of lifestyle ... wounds and in affordability of better quality of wound ... care market. Universal coverage of public health insurance schemes ... further stimulate demand. Based on the findings of primary ...
Breaking Medicine Technology:Glycobiology / Glycomics Market Worth $928.11 Million by 2019 2Glycobiology / Glycomics Market Worth $928.11 Million by 2019 3Glycobiology / Glycomics Market Worth $928.11 Million by 2019 4Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 2Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 3Easy Breathe Now Offers World's First "Smart" CPAP Device to Treat Sleep Apnea 4China Wound Care Market 2China Wound Care Market 3
... A partnership announced today between Medical City Hospital and Dallas Fire-Rescue ... technology, as Medical City recently helped outfit all DFR rescue units ... , , ... a unique combination of web, broadband and medical technology, will drastically ...
... and HAMILTON, Bermuda , April 30 Celtic ... the biotechnology and pharmaceutical industries, announced today the enrolment of the first ... for the topical treatment of onychomycosis (also known as a fungal nail ... This Phase ...
Cached Medicine Technology:Medical City Hospital Partners With Dallas Fire-Rescue to Outfit First Mobile Units in Dallas County With Advanced EKG Technology 2Medical City Hospital Partners With Dallas Fire-Rescue to Outfit First Mobile Units in Dallas County With Advanced EKG Technology 3Medical City Hospital Partners With Dallas Fire-Rescue to Outfit First Mobile Units in Dallas County With Advanced EKG Technology 4Medical City Hospital Partners With Dallas Fire-Rescue to Outfit First Mobile Units in Dallas County With Advanced EKG Technology 5Celtic Pharma Announces Initiation of Phase III Trial of TDT 067 for the Treatment of Onychomycosis 2Celtic Pharma Announces Initiation of Phase III Trial of TDT 067 for the Treatment of Onychomycosis 3Celtic Pharma Announces Initiation of Phase III Trial of TDT 067 for the Treatment of Onychomycosis 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: