Navigation Links
Fragile X Syndrome Corrected in Mice
Date:12/19/2007

is genetic evidence further supports treatment trials and suggests that earlier use of these agents may be very beneficial, since the genetic model corrects this problem throughout development," Hagerman said.

"We are initiating mGluR5 antagonist trials in humans now, and we are excited to see the benefit in adults with fragile X," Hagerman said. "This work is ushering in a new age of targeted treatments for fragile X syndrome."

Another expert agreed.

"Needless to say, we are very excited about this publication, which has actually been in the works for a long time," said Dr. Michael Tranfaglia, the medical director of the FRAXA Research Foundation, which is focused on fragile X. "The genetic rescue of most of the major features of fragile X syndrome by decreasing the expression of mGluR5 is an elegant and powerful demonstration of the 'mGluR5' theory.'"

In this case, the breakthrough finding has led to the conclusion that fragile X syndrome is primarily the result of excessive activity in a single cellular receptor pathway, Tranfaglia said.

Drugs are currently in development that can block this receptor, Tranfaglia said. "We believe these drugs have enormous potential for the treatment of fragile X and related developmental disorders, including many cases of autism," he said.

More information

For more about fragile X syndrome, visit the Fragile X Research Foundation.



SOURCES: Mark F. Bear, Ph.D., director, Picower Institute, and Picower professor of neuroscience, MIT, Cambridge, Mass.; Michael Tranfaglia, M.D., medical director, FRAXA Research Foundation, Newburyport, Mass; Randi Hagerman, M.D., professor, pediatrics, and medical director, M.I.N.D. Institute, University of California, Davis; Dec. 20, 2007, Neuron


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. $21.8 Million NIH Grant for Fragile X Research
2. Stem cell research produces a key discovery for Fragile X Syndrome
3. Brain Defect Helps Drive Fragile X Syndrome
4. Fragile X Foundations Sign Merger Agreement
5. Diabetes appears to increase risk of death for patients with acute coronary syndromes
6. Eye-staining technique offers early detection for dry eye syndrome
7. Pollen, Fruits, Veggies Help Trigger Oral Allergy Syndrome
8. Treating depression may improve recovery of heart rate variability following coronary syndromes
9. Metabolic syndrome heightens risk for development of uric-acid kidney stones
10. Stomach Virus a Culprit in Chronic Fatigue Syndrome
11. Chronic fatigue syndrome linked to stomach virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Fragile X Syndrome Corrected in Mice 
(Date:9/23/2014)... Dallas, Texas (PRWEB) September 23, 2014 ... Gunn Finance Tough Mudder team just completed the ... class obstacle course event that helps fund the wounded ... Finance Tough Mudder team member, the ”Tough Mudder is ... military-style obstacle course. Designed and created by British Special ...
(Date:9/23/2014)... University of Cambridge has found that a common characteristic of ... ,signature, in the brain. The results are published today (23 ... The researchers studied 80 adult men with autism: 38 who ... found that language delay was associated with differences in brain ... lobe, insula, ventral basal ganglia, which were all smaller in ...
(Date:9/23/2014)... Published by Nationwide Lifts, the book is designed ... of their mobility in a new way, using equipment that ... lifts are that equipment and can bring mobility and ... elevator business, I’ve seen so many people struggle with ... one with mobility issues,” said Andy Darnley, co-founder and president ...
(Date:9/23/2014)... a popular supplier of wedding dresses and special occasion gowns ... marine ball dresses . Along with this, the firm has ... items; all of them are now provided with deep discounts, ... has won more than 2000 happy customers in the global ... and after-sale services. The company is offering thousands of graceful ...
(Date:9/22/2014)... Recently, BamboofloorChina.com, an outstanding online supplier ... solid bamboo floors . According to the company’s ... at discounted rates, up to 30 percent off. The ... , BamboofloorChina.com is good at making ... are made according to the newest customer feedback. A ...
Breaking Medicine News(10 mins):Health News:Presence or absence of early language delay alters anatomy of the brain in autism 2Health News:Nationwide Lifts, America’s Leader in Home Elevators, Is Proud to Announce the Release of Its First Book, “Stair Lifts: Move Up, Not Out!” 2Health News:Fashionable Marine Ball Dresses Added To BuyTopDress.com’s Collection 2Health News:Cheap Solid Bamboo Floors From Outstanding Online Supplier BamboofloorChina.com 2
... Geneva, Switzerland, Friday, 25 June 2010: Today, world renowned ... latest trends in treatment and cutting edge research in ... hepatocellular carcinoma (HCC) the third most common cause ... of death among patients with liver cirrhosis. ...
... By Ellin Holohan HealthDay Reporter , FRIDAY, ... from chronic migraine headaches feel more rejected, ridiculed, and ... other neurological troubles, a new study contends. And ... victims experience, the Philadelphia researchers say. Lead author ...
... ... Prefer Use of Blood Tests, including QuantiFERON®-TB, to Diagnose Tuberculosis Infection in Certain Populations ... Valencia, CA ... Prevention (CDC) issued new and important guidelines on the detection of Mycobacterium tuberculosis infections, ...
... THURSDAY, June 24 (HealthDay News) -- A new drug, the ... people with type 2 diabetes who are already taking the ... helped patients lose weight, is novel in that it does ... a study appearing in the June 26 issue of ...
... ... Climate Savers Computing Initiative, a non-profit organization dedicated to reducing computer power consumption by 50 ... ... joined the Climate Savers Computing Initiative, a non-profit organization dedicated to reducing computer power consumption ...
... ... with a new technology that the skin care industry has pursued for years: enhanced ... ... new technology that the skin care industry has pursued for years: enhanced absorption. ...
Cached Medicine News:Health News:International liver cancer congress provides possible solutions to reduce significant burden 2Health News:International liver cancer congress provides possible solutions to reduce significant burden 3Health News:For Migraine Sufferers, Stigma Adds to Burden 2Health News:For Migraine Sufferers, Stigma Adds to Burden 3Health News:TB Claims One Life Every 17 Seconds; Almost Two Million People Each Year 2Health News:TB Claims One Life Every 17 Seconds; Almost Two Million People Each Year 3Health News:Drug Helps Tackle Type 2 Diabetes in New Way, Study Says 2Health News:Drug Helps Tackle Type 2 Diabetes in New Way, Study Says 3Health News:Be Green Canada Joins Computing Initiative 2Health News:Be Green Canada Joins Computing Initiative 3Health News:New Anti-Aging Skin Care Line Promotes Penetration 2
(Date:9/22/2014)... Sept. 22, 2014 Children,s National Health ... Sept. 29 at 5 p.m. EDT for its ... in response to continued strong interest from inventors.  ... will be awarded to the winning presentations at ... Symposium hosted by Children,s National in October. For ...
(Date:9/22/2014)... BROOK, N.J. , Sept. 22, 2014 /PRNewswire/ ... antibody therapies to treat infectious disease, today announced ... volunteer safety studies of obiltoxaximab (ETI-204). Obiltoxaximab is ... inhalational anthrax and data from these studies support ... administered intravenously (IV) at the intended therapeutic dose. ...
(Date:9/22/2014)... and SHANGHAI , ... Group (BHG), a global knowledge leader in healthcare ... partnership to support healthcare innovation in ... personal connected health technologies. Continua and BHG announced ... Forum being held this week in ...
Breaking Medicine Technology:Calling all medical innovators: Submit your pediatric medical device pitch for Children's National competition by Sept. 29 2Calling all medical innovators: Submit your pediatric medical device pitch for Children's National competition by Sept. 29 3Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 2Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 3Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 4Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 5Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 6Continua and Borderless Healthcare Group Form Strategic Partnership, Launch the Healthcare Technology Innovation Center in Shanghai 2Continua and Borderless Healthcare Group Form Strategic Partnership, Launch the Healthcare Technology Innovation Center in Shanghai 3Continua and Borderless Healthcare Group Form Strategic Partnership, Launch the Healthcare Technology Innovation Center in Shanghai 4
... ULURU Inc. (NYSE Amex: ULU ) ... discuss the third quarter ended September 30, 2010 financial results ... 12, 2010 at 9:00 a.m. Eastern Time. To ... international callers dial (850) 429-1388 (access code 23699#) five to ...
... GAITHERSBURG, Md., Nov. 8, 2010 GenVec, Inc. (Nasdaq: ... ended September 30, 2010.   GenVec reported a net ... ended September 30, 2010 compared to a net loss of $3.6 ... the nine months ended September 30, 2010, GenVec,s net loss was ...
Cached Medicine Technology:ULURU Inc. Announces Conference Call 2GenVec Reports Third Quarter 2010 Financial Results 2GenVec Reports Third Quarter 2010 Financial Results 3GenVec Reports Third Quarter 2010 Financial Results 4GenVec Reports Third Quarter 2010 Financial Results 5
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: