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Fox Chase researchers improve accuracy of IMRT delivery in post-prostatectomy patients
Date:10/5/2011

MIAMI BEACH, FL (October 5, 2011)Prostate cancer is the most common cancer in men in the United States, as well as the second leading cause of cancer-related deaths in this population. Many of these patients undergo surgical removal of their prostate, followed by radiation therapy applied to their prostate bed the space where the prostate was once situated.

The most common technique of post-prostatectomy radiation is Intensity Modulated Radiation Therapy (IMRT), in which radiation beams closely conform to the area of interest while sparing normal adjacent healthy structures. To ensure its optimal effectiveness in post-prostatectomy patients, clinicians should precisely deliver the radiation beams to the prostate bed and avoid crucial structures such as the bladder and rectum.

A new study led by researchers at Fox Chase Cancer Center has revealed that a portion of the prostate bed is located outside IMRT treatment margins in a significant percentage of post-prostatectomy patients, suggesting that they may be receiving too little treatment in the appropriate area and too much in surrounding structures during the course of their treatment. This study, the first to examine in detail the location and motion of the prostate bed during IMRT delivery, will be presented by Tracy Klayton, M.D., a senior radiation oncology resident at Fox Chase, at the 53rd Annual Meeting of the American Association for Radiation Oncology on Wednesday, October 5th.

In the study, Klayton and her team localized the prostate bed in 20 post-prostatectomy patients who underwent a total of more than 600 IMRT sessions at Fox Chase. The researchers used the Calypso 4D Localization System, which involves implanting three radiofrequency transponders, each the size of a grain of rice, in the prostate bed to pinpoint its location at the beginning of daily radiation therapy sessions and to continuously track its movement during the entire setup period and treatment del
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Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

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