Navigation Links
Fox Chase researchers identify new mechanism used by cells to reverse silenced genes
Date:6/30/2011

PHILADELPHIA (June 30, 2011)Scientists at Fox Chase Cancer Center have discovered a new mechanism used by cells in the body to turn on silenced genes. This process is critical in preventing the development of cancersuggesting the possibility of new therapies that might target the specific changes underlying the disease. The findings will be published online in the journal Cell on June 30, 2011.

The process investigated by Alfonso Bellacosa, M.D., Ph.D., Associate Professor at Fox Chase, and his colleagues, is called methylation, in which the cell chemically tags genes to turn them off. More specifically, the cell silences a gene by adding a chemical compound known as a methyl group; without that methyl group, the gene remains active.

It's a process of great interest to scientists, Bellacosa explains, because methylation is a key part of normal gene regulation but, when it silences the genes that normally suppress tumors, it results in cancer. Indeed, some cancer drugs work by demethylatingmeaning, removing methyl groups from DNA. But those drugs will demethylate DNA non-specifically, he says, causing side effects and other problems.

Scientists have been investigating for years how the cell adds methyl groups to genes to turn them off, but have been less clear about the process of demethylation. For instance, some have suspected that demethylation only occurs passively, such as when DNA with an attached methyl group replicates, creating new DNA without a methyl group.

Now, Bellacosa and his team present the first direct evidence that demethylation can be, in fact, an active process, controlled by a specific protein along with clues about how to act on it in a targeted way.

The researchers found that one protein called thymine DNA glycosylase or TDGknown to help repair DNAis also responsible for removing methyl groups from DNA. Studies with mice that lacked TDG activity indicated the gene was needed for s
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Hollywood-Style Liposuction Comes to DC: Chevy Chase Smartlipo Brings Revolutionary Laser-Assisted Liposuction to DC Metro Area
2. Torchmark Corporation Declares Dividend and Resumes Stock Repurchases
3. International Merchant Advisors to Complete Purchase of Medical Marijuana Company Organic Science, Inc.
4. Grand Opening of LIFE Ionizer Australia Launches with a Free Ionizer Upgrade with Purchase of Alkaline Water Ionizer from LIFE Ionizer Australia
5. A New Twist On Convert to Purchase
6. Ensemble Healthcare Properties Purchases North Valley Medical Plaza
7. ARI Purchases Intercytex Assets
8. CapSite™ Provides Detailed Transparency on Healthcare Technology Purchases
9. Ivory Homes Plans Ahead for the April 30th Home Buyer Tax Credit Deadline with 100 New Homes Ready for Quick Purchase
10. R-Biopharm Group Purchases a Majority Ownership in Trilogy Lab, Expanding US Operations
11. Fox Chase clinical trial tests first of its kind antibody
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... , ... June 30, 2015 , ... ... in order to enhance successful student outcomes. According to Dr. Theo Wubbels ... to adapt.” Teachers must be able to show “all kinds of behavior when ...
(Date:6/30/2015)... ... 2015 , ... Americans report feeling more stressed than ever before. There’s even ... stressed out people right over the edge. , Almost half of Americans report ... night. Sleeping pills now lead the list of the most prescribed medications, despite reported ...
(Date:6/30/2015)... ... , ... Curly Hair Solutions™ is honoured to attend Cosmoprof North America in ... products from all over the world. For the first time ever, Curly Hair Solutions™ ... styling products focused entirely on meeting the needs of all curl types ...
(Date:6/29/2015)... ... ... Sublime Beauty NATURALS® introduces its new USDA Certified Organic Sesame Oil this ... and even culinary uses, was especially designed for Oil Pulling. , To transform ... can accomplish this. Oil Pulling is an Ayurvedic practice that is easy and very ...
(Date:6/29/2015)... Lexington, Kentucky (PRWEB) , ... June 30, 2015 , ... ... with Kentucky Orthopedic Rehab Team (KORT) as it becomes the Official Physical and Occupational ... at the 2015 Rolex Kentucky Three-Day Event presented by Land Rover. , ...
Breaking Medicine News(10 mins):Health News:Lessons On Leadership - Top 12 Global Teacher Bloggers Reveal the Best Strategies for Building Positive Leadership in Global Classrooms 2Health News:Wake UP Happy and Sleep Soundly with Famous Experts with My Wake UP Call® Motivational Alarm Clock® Messages and My Good Night Messages™ - Now Available at Audible! 2Health News:Wake UP Happy and Sleep Soundly with Famous Experts with My Wake UP Call® Motivational Alarm Clock® Messages and My Good Night Messages™ - Now Available at Audible! 3Health News:Curly Hair Solutions™ Showcases Entire Curl Keeper™ Collection at Cosmoprof Las Vegas July 12 - 14 2Health News:New Product: Transform Wellness and Oral Health With This Ancient Ayurvedic Secret and Organic Product from Sublime Beauty NATURALS® 2Health News:KORT Physical Therapy Announces Partnership with The United States Equestrian Federation 2
... MS, ... and sharing her story of hope and determination. , ... Bayfield, WI (PRWEB) April 7, 2010 -- Hopeful climbers have begun streaming in to ... highest peak. Last year,s successful climbers whose summit of Everest also completed their ...
... ... their newest Low level laser for body sculpting. Surprisingly Zerona has also been clinically ... addition to lowering the levels of Lipoprotein (LDL). , ... Houston, TX (PRWEB) April 6, 2010 -- A ...
... ... conversations about your brand, advertising campaign, competitors or product innovations. , ... (PRWEB) April 6, 2010 -- Six ... an easy, affordable way to gather insights needed to optimize marketing strategies, increase advertising ...
... for treatment, at higher rates than expected , TUESDAY, April ... visit hospitals repeatedly in search of treatment, according to new ... of sickle cell patients who visited the hospital returned within ... the ages of 18 and 30, were especially likely to ...
... An approach designed to reduce HIV/STDs previously used ... community-based organizations (CBOs), an important component in national strategies ... "at risk" youths can be reached. , A ... tested whether a proven HIV/STD risk-reduction intervention would work ...
... work better in protecting children from flu if they included ... Louis University research has found. "Adding a second influenza ... some of the guesswork out of strain selection and help ... M.D., lead investigator and director of the Center for Vaccine ...
Cached Medicine News:Health News:Woman with MS Summits Everest and Completes the Seven Summits 2Health News:Woman with MS Summits Everest and Completes the Seven Summits 3Health News:"Zerona" Lipo-Laser Penetrates Wellness Industry for Anti-aging, Weight Loss, Body Sculpting and Cardiac Health 2Health News:"Zerona" Lipo-Laser Penetrates Wellness Industry for Anti-aging, Weight Loss, Body Sculpting and Cardiac Health 3Health News:Sickle Cell Disease Patients Seek Acute Pain Care Repeatedly 2Health News:Sickle Cell Disease Patients Seek Acute Pain Care Repeatedly 3Health News:Roll-out of proven HIV/STD risk-reduction intervention with teens by community groups successful 2Health News:Building a better flu vaccine: Add second strain of influenza B 2
(Date:6/29/2015)... 29, 2015  New guidelines released today by ... give hope for better outcomes to the hundreds ... ischemic stroke each year. Stryker,s Trevo ® ... in the clinical trials that provided data for ... strongly recommend endovascular therapy with stent retrievers for ...
(Date:6/29/2015)... PAUL, Minn. , June 29, 2015 ... manufacturer of devices that use neuroblocking technology to treat ... that it has commenced an underwritten public offering of ... common stock, Series A warrants to purchase common stock ... whose purchase of units in the offering would result ...
(Date:6/29/2015)... Sciences, Inc. (NASDAQ: ALIM ) (Alimera), a pharmaceutical ... of prescription ophthalmic pharmaceuticals, today announced that Rick ... will present at the 2015 Cantor Fitzgerald Inaugural Healthcare ... at Le Parker Meridien Hotel in New ... webcast live and will be available for access, along ...
Breaking Medicine Technology:New AHA Guidelines For The Early Management And Treatment Of Stroke Will Change The Standard Of Care For Thousands Of Stroke Patients Each Year 2New AHA Guidelines For The Early Management And Treatment Of Stroke Will Change The Standard Of Care For Thousands Of Stroke Patients Each Year 3EnteroMedics Inc. Announces Proposed Public Offering of Common Stock and Warrants 2EnteroMedics Inc. Announces Proposed Public Offering of Common Stock and Warrants 3
... , ATLANTA , Feb. 8 ... an Atlanta -based, biopharmaceutical company developing human vaccines for ... agents, today provided an update on its vaccine trials progress. ... rate, 60,000 new infections annually, and that,s just in ...
... , PORTLAND, Ore. , Feb. 8 ... use of localized content by sales teams. Together, the companies ... translated content to reach the hands of global sales professionals ... sales cycle. This combination gives the sales person the right ...
Cached Medicine Technology:GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA 2GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA 3GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA 4GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA 5GeoVax Labs, Inc. Begins Enrollment at Final Site for Preventative Vaccine; Next Step Is to Submit IND Application for Therapeutic Vaccine to FDA 6Prolifiq and viaLanguage Announce Partnership: Accelerate the Use of Localized Content by Sales Teams 2Prolifiq and viaLanguage Announce Partnership: Accelerate the Use of Localized Content by Sales Teams 3
Inquire...
... Tips offer a safe alternative to using ... for applications such as PCR(a), pipetting radioactive ... Tips are excellent for tissue culture, gel ... Tips prevent aerosol contaminants and liquids from ...
... Eliminate aerosol contamination, ... reactions in PCR. Hydrophobic, ... Only air can pass ... tips, in contrast to ...
... Finntip Filters are ideal ... methods, or for any work ... They are designed for pipetting ... samples, and other. For applications ...
Medicine Products: