Navigation Links
Fox Chase researchers find that fish oil boosts responses to breast cancer drug tamoxifen
Date:4/6/2011

ORLANDO, FL (April 6, 2011) Breast cancer is the second most common cancer among women, with more than 200,000 women diagnosed each year. Being exposed to estrogen over a long period of time is one factor that can increase a woman's risk of developing the disease. One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen. Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acidsabundant in fishcould be a safe and beneficial booster for tamoxifen therapy.

Jose Russo, MD, director of the Breast Cancer Research Laboratory at Fox Chase, will present the new findings at the AACR 102nd Annual Meeting 2011 on Wednesday, April 6.

To investigate how fish oil intensifies the effects of tamoxifen, Russo, in collaboration with a team led by Andrea Manni, MD, from Pennsylvania State University, induced mammary tumors in rats and then divided the animals into four groups. They fed the groups either a 17 percent fish oil diet, with or without tamoxifen, or a 20 percent corn oil diet, with or without tamoxifen, for eight weeks. They then analyzed gene expression patterns in the tumors. Omega-3 fatty acids produced a greater expression of genes related to cellular specialization, or differentiationa sign of lower cancer severitycompared to corn oil. The combination of fish oil and tamoxifen reduced the expression of genes linked to tumor growth and spreading.

"If a tumor was being treated with tamoxifen, the addition of an omega-3 fatty acid diet seemed to make the tumor, at least at the molecular level, more benign and less aggressive and responsive to tamoxifen," says Russo.

The fish oil diet also boosted the expression of genes related to immune defenses against tumors, more so than did the corn oil diet. But omega-3 fatty acids simultaneously increased the expression of genes that trigger counterproductive immune responses, such as inflam
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
2. Fox Chase scientists report interplay between cancer and aging in mice
3. Fox Chase researchers develop a screen for identifying new anticancer drug targets
4. Calorie labeling has no effect on teenagers or parents food purchases
5. Fox Chase researchers uncover new risk factors for brain metastases in breast cancer patients
6. Fox Chase researchers identify risk factors for the spread of breast cancer to lymph nodes
7. Cash is healthier? Credit and debit increase impulsive food purchases
8. CerMedia Completes Purchase of Cell-Pore Principal Assets from NanoDynamics
9. Fox Chase clinical trial tests first of its kind antibody
10. R-Biopharm Group Purchases a Majority Ownership in Trilogy Lab, Expanding US Operations
11. Ivory Homes Plans Ahead for the April 30th Home Buyer Tax Credit Deadline with 100 New Homes Ready for Quick Purchase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2015)... March 28, 2015 Take a bite ... kicks into action. Acids tumble into the stomach, ready ... faulty valve-like structure lets these acids run amok, triggering ... extremely common symptom. More than 60 million Americans have ... examine where heartburn starts, and how it can be ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 Thousands ... devices manufactured by C.R. Bard, Inc. continue to ... U.S. District Court, Southern District of West Virginia, ... serving on the Plaintiffs’ Steering Committee. According ... has granted certain defendants named in those lawsuits ...
(Date:3/28/2015)... Emergency Medical Care (EMC), a New ... recently commemorated its three-year anniversary of being the only ... to 24-hour urgent care, Emergency Medical Care offers its ... time, Emergency Medical Care’s Urgent Care NYC ... eye injuries, ear infections, fevers, insect bites, burns, animal ...
(Date:3/28/2015)... New York, NY (PRWEB) March 28, 2015 ... 2015 highlighted a problem which could prove critical to ... Why system testing, a critical aspect of data security, ... payment card industry data security report, every major category ... vulnerability scanning and penetration testing. “With all the craziness ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 Pitching speed, player’s ... history of shoulder and elbow injuries, according to new research ... ( AOSSM ) Specialty Day. , “Our findings indicate that ... 20% increase in likelihood of a history of injury, a ... a 12% increase likelihood of a history of injury, and ...
Breaking Medicine News(10 mins):Health News:Bypass Your Heartburn Worries This Easter With Tylers Coffee 2Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 2Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 3Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 4Health News:Emergency Medical Care Celebrates Three Years of 24/7 Walk-In Urgent Care Services 2Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 2Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 3Health News:Businesses Dealing With PCI Falling Short On Regular Vulnerability Scans and Pen Testing 4Health News:Researchers Highlight Shoulder and Elbow Injury Possibility in Youth Players 2
... for Brain Research in Frankfurt and at The Field Museum ... fruit bats (flying foxes) possess cones in addition to rods. ... cells, the cones for daylight vision and colour vision, and ... bats were traditionally believed to possess only rods. Hence, fruit ...
... years or more of oral steroid treatment decreases the risk ... effects were found regardless of when in the course of ... effects were not observed if the steroids were taken for ... cons of corticosteroid treatment in rheumatoid arthritis have been a ...
... an overhaul in the process used to inspect and ... ,Last fall, grocers and shoppers were in a panic ... contaminated bagged spinach. Nationwide there were 204 illnesses, 104 ... ,The FDA concluded it could not definitively determine how ...
... Ginza district Friday as they urged a boycott of ... ,Walking arm-in-arm, three women walked up to the ... wearing nothing but a banner reading: "The naked truth: ... of the protest by People for the Ethical Treatment ...
... of the public health system in the US keeps tumbling ... stated that adults// with serious mental illness and treated in ... ,The gap has widened since the early '90s ... 15 years. ,"We're going in the wrong direction ...
... headway in the development of an investigative blood test ... complications in the bone marrow, leading to life threatening ... Medical Research Institute (MMRI) and Sydney's West mead Hospital ... blood test to detect such tendencies. ...
Cached Medicine News:Health News:Research on Fruit Bats 2Health News:Research on Fruit Bats 3Health News:Long-term Oral Steroid Therapy Decreases Lymphoma Risk in Rheumatoid Arthritis 2Health News:FDAs Failure Urges It to Reassess Its Policies 2Health News:Major Mental Disorders Cut Life Span by Ten to Fifteen Years 2
(Date:3/27/2015)... NEW YORK , March 27, 2015 ... ), the leading source of health information, ... on the new National Action Plan ... interview, President Obama emphasized the urgency and ... impact on national and global health.    ...
(Date:3/26/2015)... - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" or the "Company"), ... therapies for cardiovascular disease and overall health, announced that ... of the Corporation (the "Common Shares"). The Common Shares ... 5 th , 2014 to March 4 th , ... on or before April 1, 2015. Interest on the ...
(Date:3/26/2015)... "Whether it,s our family, our friends, all ... In a single sentence, Dr. Anthony Coyle , ... Centers for Therapeutic Innovation (CTI), sums up ... America,s biopharmaceutical companies. CTI,s unique model ... foundations and the National Institutes of Health (NIH) to ...
Breaking Medicine Technology:Exclusive: WebMD Interviews President Obama About Plan for Combating Antibiotic Resistance 2Exclusive: WebMD Interviews President Obama About Plan for Combating Antibiotic Resistance 3Pivotal Therapeutics announces payment of interest on outstanding convertible notes 2Collaboration for Cures: Teaming Up to Advance Science and Save Lives 2
... , , NASHVILLE, Tenn. ... leading provider of medical cost management services, today commended two ... CT scans and other diagnostic imaging tests. , "When ... treatment," said Gregg Allen, M.D., chief medical officer of MedSolutions. ...
... , ATLANTA, Dec. 16 Medlytix, a ... a key half-billion dollar milestone - the total amount of ... to more than a half-million patients nationwide by doing a ... than two years. , "We,re proud that each of these ...
Cached Medicine Technology:MedSolutions Applauds Renewed Focus on the Dangers of Radiation Exposure 2MedSolutions Applauds Renewed Focus on the Dangers of Radiation Exposure 3Healthcare Scoring System Allows Hospitals To Increase Charity Care 2Healthcare Scoring System Allows Hospitals To Increase Charity Care 3Healthcare Scoring System Allows Hospitals To Increase Charity Care 4
... Endo-Surgery provides clip appliers in 10mm and ... appliers provide precise clip placement., ,The ... These preloaded, single-trigger instruments are designed to ... a 5mm trocar, through a 5mm reducer ...
... and IMMULITE 1000 assays are ... IMMULITE and IMMULITE 1000, continuous ... offer simplicity in both design ... be found in a wide ...
The C-Reactive Protein (CRP) assay is used for the quantitative analysis of C-reactive protein in human serum and plasma. Kit is for use with the Abbot Laboratories Aeroset, ARCHITECT c8000 or ARCHI...
... new windows for the laboratory in flexibility, ... move from one function to another. You ... and add a new patient record simultaneously. ... track of all the open functions and ...
Medicine Products: