Navigation Links
Fox Chase researchers find that fish oil boosts responses to breast cancer drug tamoxifen
Date:4/6/2011

ORLANDO, FL (April 6, 2011) Breast cancer is the second most common cancer among women, with more than 200,000 women diagnosed each year. Being exposed to estrogen over a long period of time is one factor that can increase a woman's risk of developing the disease. One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen. Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acidsabundant in fishcould be a safe and beneficial booster for tamoxifen therapy.

Jose Russo, MD, director of the Breast Cancer Research Laboratory at Fox Chase, will present the new findings at the AACR 102nd Annual Meeting 2011 on Wednesday, April 6.

To investigate how fish oil intensifies the effects of tamoxifen, Russo, in collaboration with a team led by Andrea Manni, MD, from Pennsylvania State University, induced mammary tumors in rats and then divided the animals into four groups. They fed the groups either a 17 percent fish oil diet, with or without tamoxifen, or a 20 percent corn oil diet, with or without tamoxifen, for eight weeks. They then analyzed gene expression patterns in the tumors. Omega-3 fatty acids produced a greater expression of genes related to cellular specialization, or differentiationa sign of lower cancer severitycompared to corn oil. The combination of fish oil and tamoxifen reduced the expression of genes linked to tumor growth and spreading.

"If a tumor was being treated with tamoxifen, the addition of an omega-3 fatty acid diet seemed to make the tumor, at least at the molecular level, more benign and less aggressive and responsive to tamoxifen," says Russo.

The fish oil diet also boosted the expression of genes related to immune defenses against tumors, more so than did the corn oil diet. But omega-3 fatty acids simultaneously increased the expression of genes that trigger counterproductive immune responses, such as inflam
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
2. Fox Chase scientists report interplay between cancer and aging in mice
3. Fox Chase researchers develop a screen for identifying new anticancer drug targets
4. Calorie labeling has no effect on teenagers or parents food purchases
5. Fox Chase researchers uncover new risk factors for brain metastases in breast cancer patients
6. Fox Chase researchers identify risk factors for the spread of breast cancer to lymph nodes
7. Cash is healthier? Credit and debit increase impulsive food purchases
8. CerMedia Completes Purchase of Cell-Pore Principal Assets from NanoDynamics
9. Fox Chase clinical trial tests first of its kind antibody
10. R-Biopharm Group Purchases a Majority Ownership in Trilogy Lab, Expanding US Operations
11. Ivory Homes Plans Ahead for the April 30th Home Buyer Tax Credit Deadline with 100 New Homes Ready for Quick Purchase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... The special two-day sale starts today on the fan-favorite ... code 20SCRUB at the webstore checkout. The sale expires midnight ... Citrus Scrub falls in love with it," says Sublime ... cleanser for face, but can also be used on the ... exfoliate with pleasure, clean pores and wash away dead skin ...
(Date:7/13/2014)... MED-Ed Facilities is seeking proposals from qualified ... 7+8 in Boston at the Seaport Hotel. Case ... Presentations by individuals or teams are welcome. Please submit ... of sessions that were presented last year, go to ... , Conference Director, The successful planning and design ...
(Date:7/13/2014)... July 13, 2014 Manchester United and ... the 2014 Guinness International Champions Cup. The 2014 ICC ... each year because of the talent of it brings in. ... AS Roma will compete in the 2014 event spread across ... 24 with a game between Olympiacos and Milan and will ...
(Date:7/13/2014)... ladies are extremely responsive to Angeldress.co.uk’s pink bridesmaid ... and has created a lot of new items recently. ... that responded directly to customers’ demands. , Angeldress.co.uk ... The company’s pink bridesmaid dresses come in many different ... the best products for customers from around the world. ...
(Date:7/13/2014)... The Lancet Neurology calls for sports ... neurological problems that repeated concussions can cause. , ... sports-related traumatic brain injury (TBI), and the long-term ... lateral sclerosis, and other neurological disorders, say the ... is that even when the symptoms of concussion ...
Breaking Medicine News(10 mins):Health News:Discover the Favorite Sublime Beauty® Citrus Scrub: Special "Two-Day Only" Sale 2Health News:MED-Ed Facilities Conference Call for Speakers Open 2Health News:Manchester United vs. AS Roma Tickets in Denver, CO at Sports Authority Field at Mile High: Ticket Down Slashes Ticket Prices on International Champions Cup in Denver 2Health News:Manchester United vs. AS Roma Tickets in Denver, CO at Sports Authority Field at Mile High: Ticket Down Slashes Ticket Prices on International Champions Cup in Denver 3Health News:Angeldress.co.uk Announces Summer Sale For Pink And Red Bridesmaid Dresses; The Current Discount Is Up To 80% Off 2
... A new study shows there is some truth in the ... the brain active. It is long been believed that mental ... the Rush Alzheimer's Disease Centre in the US now reveal ... ongoing Religious Orders Study, involving the cognitive health of older ...
... research has established that a decreased white blood ... aggressive periodontitis.The scientists showed that at six weeks of ... of their alveolar bone whereas the normal mice had ... which anchors teeth in place, is an indication of ...
... said that older hospital patients with delirium run a ... condition. Researchers suggested there's a need for research to ... to investigate interventions that can be made after discharge ... study covered 361 patients aged 65 or older, of ...
... Better health may be only a dash and sprinkel ... found that herbs, in addition to making food tastier, ... potential anticancer benefits when supplementing a balanced diet.Herbs have ... including garlic, the researchers say. Their findings appear in ...
... was found using new technology which helps prevent stroke. One ... by ultrasound, at any blockages in the carotid arteries that ... the US have pioneered the use of a portable device, ... 20 people, this was used to take two different images ...
... measles, mumps and rubella is in short supply. The ... with shortfalls caused by production problems, fewer drugmakers// and ... ,The situation is so bad that 8 of the ... tetanus, diphtheria and a pneumococcal vaccine used to prevent ...
Cached Medicine News:Health News:Herbs: rich soure of antioxidants 2
(Date:7/11/2014)... , July 11, 2014  Kindred Hospital Houston ... announce the opening of its new outpatient wound ... services to people with chronic, hard to heal ... can lead to amputation, lower leg wounds related ... delayed closure, and traumatic injury wounds which are ...
(Date:7/11/2014)... ST. LOUIS , July 11, 2014 ... medical device company, announced today the positive, ... of its innovative SPiNPerc™ procedure. The SPiNPerc ... use of a percutaneous approach to biopsy ... possible.  Hospitals, patients and physicians experience positive ...
(Date:7/10/2014)... CLEVELAND , July 10, 2014  The U.S. ... a three-year grant to University Hospitals (UH) Case Medical ... a new national model aimed at improving care for ... Oncology Care," the project will test a unique model ... patients with late-stage disease, significant comorbidities, or demonstrated need ...
Breaking Medicine Technology:Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Veran Medical Publishes Lung Cancer Patient Management Study 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4
... N.J., Oct. 27 Savient Pharmaceuticals, Inc. (Nasdaq: ... results for the third quarter 2010 following the close of ... Paul Hamelin, President, and David Gionco, Group Vice President, Chief ... call beginning at 9:00 a.m. Eastern Time on Friday, November ...
... 27 Express Scripts, Inc. (Nasdaq: ESRX ) announced ... or $0.57 per diluted share.  Third quarter adjusted earnings per share, ... increase of 55% over 2009. Third Quarter ... Tables 2 and 3) Total adjusted claims of ...
Cached Medicine Technology:Savient Pharmaceuticals to Hold Third Quarter 2010 Financial Results Conference Call on Friday, November 5, 2010 2Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 2Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 3Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 4Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 5Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 6Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 7Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 8Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 9Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 10Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 11Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 12Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 13Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 14Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 15Express Scripts Announces Record Third Quarter Earnings and 2011 Guidance 16
... from DePuy offers a comprehensive combination of ... OSHA recommendations regarding occupational exposure to blood ... standard for comfort. , ,The Nighthawk, a ... from DePuy, is a personal protection system ...
... setup, try Cadwell paired disc electrodes. They ... custom-molded contacts are 10 mm (0.4 in) ... stainless steel with a locator pin on ... coded and available in twisted pairs. Shielded ...
... Headlight Video Camera System (NTSC)With Maxenon ... Provides surgeon's eye view of any ... tapes or digital files for later ... from 8" to 36". Automatic Iris ...
... Wrap-around, silver/silver chloride ring electrodes ... For use with minicrocodile clip ... 10 cm (4 in) long, ... Each 100-count package contains 50 ...
Medicine Products: