Navigation Links
Fox Chase researchers find that fish oil boosts responses to breast cancer drug tamoxifen
Date:4/6/2011

ORLANDO, FL (April 6, 2011) Breast cancer is the second most common cancer among women, with more than 200,000 women diagnosed each year. Being exposed to estrogen over a long period of time is one factor that can increase a woman's risk of developing the disease. One way a woman can combat this risk factor is by taking the breast cancer drug tamoxifen, which interferes with the activity of estrogen. Now, researchers at Fox Chase Cancer Center have found that omega-3 fatty acidsabundant in fishcould be a safe and beneficial booster for tamoxifen therapy.

Jose Russo, MD, director of the Breast Cancer Research Laboratory at Fox Chase, will present the new findings at the AACR 102nd Annual Meeting 2011 on Wednesday, April 6.

To investigate how fish oil intensifies the effects of tamoxifen, Russo, in collaboration with a team led by Andrea Manni, MD, from Pennsylvania State University, induced mammary tumors in rats and then divided the animals into four groups. They fed the groups either a 17 percent fish oil diet, with or without tamoxifen, or a 20 percent corn oil diet, with or without tamoxifen, for eight weeks. They then analyzed gene expression patterns in the tumors. Omega-3 fatty acids produced a greater expression of genes related to cellular specialization, or differentiationa sign of lower cancer severitycompared to corn oil. The combination of fish oil and tamoxifen reduced the expression of genes linked to tumor growth and spreading.

"If a tumor was being treated with tamoxifen, the addition of an omega-3 fatty acid diet seemed to make the tumor, at least at the molecular level, more benign and less aggressive and responsive to tamoxifen," says Russo.

The fish oil diet also boosted the expression of genes related to immune defenses against tumors, more so than did the corn oil diet. But omega-3 fatty acids simultaneously increased the expression of genes that trigger counterproductive immune responses, such as inflammation and allergic reactions, which curtail the ability of cells to fight cancer and can even promote the migration of tumor cells.

More studies are needed to fully understand the effects of fish oil on the immune system, Russo says. Meanwhile, his team is examining whether omega-3 fatty acids can prevent breast cancer in animals and testing the influence of diet on breast cancer risk in women.


'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Related medicine news :

1. Fox Chase researchers report that naproxen reduces tumors in a mouse model of colon cancer
2. Fox Chase scientists report interplay between cancer and aging in mice
3. Fox Chase researchers develop a screen for identifying new anticancer drug targets
4. Calorie labeling has no effect on teenagers or parents food purchases
5. Fox Chase researchers uncover new risk factors for brain metastases in breast cancer patients
6. Fox Chase researchers identify risk factors for the spread of breast cancer to lymph nodes
7. Cash is healthier? Credit and debit increase impulsive food purchases
8. CerMedia Completes Purchase of Cell-Pore Principal Assets from NanoDynamics
9. Fox Chase clinical trial tests first of its kind antibody
10. R-Biopharm Group Purchases a Majority Ownership in Trilogy Lab, Expanding US Operations
11. Ivory Homes Plans Ahead for the April 30th Home Buyer Tax Credit Deadline with 100 New Homes Ready for Quick Purchase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/17/2017)... ... February 17, 2017 , ... ... exhibitor at Molecular Medicine Tri-Conference February 20 – 22 in San Francisco. As ... showcase its anatomic and molecular pathology workflow solution, as well as its new ...
(Date:2/17/2017)... ... 2017 , ... Top neuroendocrine cancer doctors, nurses and specialists from around the ... - 23 in Beaver Creek, CO. It was announced today by Cindy Lovelace, executive ... Beaver Creek, hosting over 60 faculty members and addressing unmet needs of the NET ...
(Date:2/17/2017)... ... February 17, 2017 , ... Dillon Ruxton ... families and business owners in the greater Fort Lauderdale metropolitan region, is embarking ... For more than 30 years, LifeNet 4 Families has provided a broad range ...
(Date:2/16/2017)... ... February 17, 2017 , ... For some cancer ... their final treatments. Physician researchers at The Marcus Institute of Integrative Health ... for efficacy in reducing symptoms of traumatic stress in cancer patients and ...
(Date:2/16/2017)... ... February 17, 2017 , ... ... planning services to families and entrepreneurs in the Birmingham area, is announcing an ... who needs assistance with her medically challenged son, Anius. , Anius is medically ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... Feb. 17, 2017  BioDigital, Inc., creators of ... of their 3D body mapping technology with eClinicalWorks, ... new integration will be used to capture and ... of the human body. BioDigital pilots show using ... while also increasing the precision of clinical annotations ...
(Date:2/17/2017)... -- Noble Capital Markets announced today that it has initiated ... EPIX ). The report was issued by Noble,s Head ... ESSA Pharmaceuticals is a clinical stage biopharmaceutical company ... lead compound EPI-506, is a small molecule oral drug ... receptor, thereby has potential to overcome some of the ...
(Date:2/16/2017)... 16, 2017 Research and Markets has ... Medical Device Technologies" report to their offering. ... Traditional medical ... general instruments, non-drug coated implantables, large endoscopes, needle based drug ... over the last two to three decades for the treatment ...
Breaking Medicine Technology: