Navigation Links
Fox Chase researchers discover novel role of the NEDD9 gene in early stages of breast cancer
Date:1/14/2013

PHILADELPHIA, PA (January 14, 2013)Breast cancer is the second leading cause of cancer deaths among women in the United States. Many of these deaths occur when there is an initial diagnosis of invasive or metastatic disease. A protein called NEDD9which regulates cell migration, division and survivalhas been linked to tumor invasion and metastasis in a variety of cancers. Researchers at Fox Chase Cancer Center have now shown that NEDD9 plays a surprising role in the early stages of breast tumor development by controlling the growth of progenitor cells that give rise to tumors. The findings, published in the journal Oncogene on January 14, 2013, could lead to personalized treatment strategies for women with breast cancer based on the levels of NEDD9 in their tumors.

"For several years, NEDD9 has been linked to tumor metastasis and invasion at later stages. This is the first study that really shows how important NEDD9 can be for the initiation of tumors in breast cancer, and to link this initiation process to progenitor cells," says lead study author Joy Little, PhD, a postdoctoral fellow at Fox Chase who works in the laboratory of senior study investigator Erica A. Golemis, PhD, Deputy Chief Scientific Officer and Vice President at Fox Chase.

In the study, Little, Golemis and their collaborators mated mice without the NEDD9 gene to mice engineered to develop HER2+ mammary tumors and unexpectedly found that these mice were largely resistant to tumor formation. Only 18% of the mice developed mammary tumors, compared with 80% of mice that had a functional NEDD9 gene. In contrast to previous research findings showing that an increase in NEDD9 levels promotes tumor aggressiveness, the researchers found that loss of NEDD9 had little effect on tumor metastasis, indicating that it is not required for this process in this specific context. Once formed, the tumors in mice lacking NEDD9 grew rapidly, suggesting that it either plays a less important role at later stages of tumor growth or tumors undergo compensatory changes that allow them to bypass the need for NEDD9.

Importantly, mice lacking NEDD9 showed a significant reduction in progenitor cell populations in the mammary gland compared with mice that had a functional NEDD9 gene. Progenitor cells from NEDD9-null mice were less likely to form three-dimensional mammospheres in culture, but proliferated at the same rate as cells from control mice. The loss of Nedd9 also made progenitor cells more sensitive to lower doses of two tumor-inhibiting drugsa Food and Drug Administration-approved Src inhibitor called dasatinib, and a focal adhesion kinase inhibitor from a class of drugs currently being tested in clinical trials for the treatment of cancer. These findings suggest that these types of drugs would more effectively control breast cancer tumors with low levels of NEDD9.

"Eventually, with a biopsy, you may be able to get a read-out of all the mutations that a tumor has, and each one would potentially dictate whether or not a certain line of therapy would work for a specific tumor," Little says. "If NEDD9 levels are higher in a particular tumor, we could potentially determine whether or not it would be more sensitive to specific inhibitors."

To follow up on this work, the researchers plan to determine the mechanisms by which NEDD9 controls tumor formation, and examine whether NEDD9 plays a similar role in early stages of other types of cancer.


'/>"/>
Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Related medicine news :

1. Fox Chase researchers find no disparities in imaging before breast cancer surgery
2. Medtronic Infuse Bone Graft Questioned As Allegations Unfold – Bisnar
3. Chase Attorneys Offer Free Consultations
4. Lax gun ownership laws could impact ability of high-risk individuals to purchase firearms
5. SOLCO Energy’s New Corporate Solar Lens Purchase Program is Helping Businesses Soar High Above the Fiscal Tax Cliff
6. Cox Pools Introduces "Simplicity of Pool Purchase" Concept
7. Most Consumers Who Purchase a Vapor Steam Cleaner From 1-800-GO-VAPOR.com Choose a Ladybug, Company Announces
8. Top Provider of Hearing Aids in Salt Lake City UT, Advanced Hearing Center, Now Offers a 36-Month Supply of Batteries with the Purchase of Any Hearing Aid
9. Cancer Genome Institute at Fox Chase among first to offer clinical blueprint of cancer genes
10. Fox Chase receives grant for community-based patient navigation services
11. NIH awards $20 million over 5 years to train next generation of global health researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 10, 2016 , ... ... the World Molecular Imaging Congress (WMIC), will be held in New York City, ... is “Imaging Biology…Improving Therapy.” The congress will highlight and emphasize how imaging reveals ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... known locally for a series of therapeutic sessions to help Los Angeles-area actors ... and in their lives. The series, known as “Mindfulness for Actors and Artists,” ...
(Date:2/10/2016)... NY (PRWEB) , ... February 10, 2016 , ... Early ... to celebrate and raise awareness of Nestlé KITKAT as the first global confectionery brand ... lives of cocoa farmers and the quality of their product, through activities that focus ...
(Date:2/10/2016)... ... ... LaserShip, a regional parcel carrier that services the eastern U.S., donated and ... in order to aid in the Flint water crisis. In 2014, LaserShip acquired Prestige ... Clio, only 15 miles away from Flint. , “We have deep roots in the ...
(Date:2/10/2016)... PLAINSBORO, N.J. (PRWEB) , ... ... ... J. Hennessy Associates, Inc. , a full-service health care communications company offering ... integrated digital news resource for practitioners and specialists working in infectious diseases. ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... -- --> --> ... Spectroscopy Market by Industry (Oil & Gas, Petrochemical, Pharmaceutical, Water ... & Mining, and Others), And Geography - Global Forecast ... expected to grow to USD 3.9 Billion by 2020, ... 2020. Browse 82 market data Tables and ...
(Date:2/10/2016)... 10, 2016 A new report from business intelligence provider ... that the Alzheimer,s disease market will more than double from just under $5 ... Annual Growth Rate (CAGR) of 11%. Canada , ... , Spain , the UK, and Japan ... period. --> Canada , France , ...
(Date:2/10/2016)... SANFORD, Fla. , Feb. 10, 2016 ... offerings today with the launch of the Specialty Pharmacy ... is an industry-first, aimed at providing real-world education, discussion ... --> --> ... President and CEO of CSI Specialty Group Suzette DiMascio, ...
Breaking Medicine Technology: