Navigation Links
Fox Chase researchers discover new mechanism of gene regulation
Date:2/26/2014

ents is limited. Research has suggested that standard therapies combined with drugs that inhibit PARP1 can kill cancer cells, but clinical trials testing PARP1 inhibitors in cancer patients have produced disappointing outcomes. "I believe that to a large extent the previous setbacks were caused by a general misconception of the role of PARP1 in living cells and the mechanisms of PARP1 regulation," Tulin says. "Now that we know this mechanism of PARP1 regulation, we can design approaches to inhibit this protein in an effective way to better treat cancer."

The ability of PARP1 to control cellular processes is regulated by nucleosomesthe basic unit of DNA packaging, consisting of a segment of DNA wound in sequence around eight histone protein cores, similar to a thread wrapped around a spool. Histones undergo different chemical modifications that play an important role in regulating the activity of genes. Through this mechanism, histones control the ability of PARP1 to activate genes and repair DNA damage.

"This mechanism of PARP1 regulation by histones is still very new," Tulin says. "People believe that PARP1 is mainly activated through interactions with DNA, but we have found that the main pathway of PARP1 activation is through interactions with the nucleosome." In the new study, Tulin and his colleagues reevaluated how PARP1 is activated by changes in the nucleosome. They found that the addition of a phosphate group to a histonecalled H2Avtriggered the entire nucleosome to change shape, exposing previously hidden parts of the nucleosome that began to interact with and activate PARP1.

To follow up on these findings, Tulin and his team are now developing the next generation of PARP1 inhibitors. Designed to block the newly identified mechanism of PARP1 activation, these new inhibitors will specifically target PARP1, in contrast to the PARP1 inhibitors currently being tested in clinical trials.

"We expect that our targeted PARP1 inhi
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. The Natural Anti-Inflammatory Supplement "Natural Body Defense" Released Online For Purchase with Extra discount Offers
2. Platinum Soursop-The natural health supplement to improve immune system and enhance Mood is finally available for purchase
3. Meratol Weight Management System Is Now Available With a Special Discount and Extra Bonuses With Every Purchase
4. Avitus Group Helps Chase Hawks Memorial Association Recruit for New Position: Executive Director
5. Porter and Chester Institute Purchases YTI Career Institute
6. Zeta Clear Christmas Sale Offers: Now Customers Can Get 3 Extra Bottles With the Purchase of 3 Without Any Additional Cost
7. African Mango Plus Christmas Discount Offer: Now Customers Can Get 50% Off on the Purchase
8. Trojan Charged Condoms Available for Online Purchase on Condomania.com
9. Acai Berry Select is Now Available With Special Bonus Offers- Now Customers Can Get One Extra Bottle Without Any Cost On the Purchase of the Product
10. "Demystifying Hyaluronic Serum", a Product Brochure From Sublime Beauty®, Is Offered After Purchase of Its Serum; on Sale Now
11. Wartrol Warts Relief Offers and Deals: Now Customers Can Get One Extra Bottle Without Additional Costs on Purchase
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Between 23 million and 50 million people suffer ... from the National Institutes of Health (NIH) and the ... them have something else in common: They have a ... Gluten Free Therapeutics, makers of CeliVites nutritional supplements, ... publishing a series of blog posts aimed at educating ...
(Date:10/1/2014)... 2014 NoteSwift Inc., announced today their ... 12.1 and 13.0. NoteSwift is the bridge between the ... navigate and document clinical information at the point of ... a patient note by more than half – and ... pain points providers state impedes EHR use according to ...
(Date:10/1/2014)... 2014 On Sept. 9, Chapín Coffee ... the Martha Stewart American Made Awards (MSAMAs), an annual ... country in the fields of crafts, design, food and ... a finalist in the MSAMAs, which celebrates entrepreneurs and ... improving local communities and changing the way we shop, ...
(Date:10/1/2014)... October is national Breast Cancer Awareness Month—an ... while raising money for breast cancer research. Pelican Water ... in the effort to find a cure. ... of having access to clean, healthy water. Research has ... certain forms of cancer. , The Problem of ...
(Date:10/1/2014)... OXNARD, CA (PRWEB) October 01, 2014 ... of the Anacapa Dental Art Institute in Oxnard and ... of Bangalore providing full mouth rehabilitation training. , “Speaking ... need of these transformative procedures to get the help ... mouth rehabilitation may involve repairing previous dental work, providing ...
Breaking Medicine News(10 mins):Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 2Health News:Informative New Blog Series Underscores Link Between Celiac Disease and Other Autoimmune Disorders 3Health News:NoteSwift Joins Allscripts Developer Program 2Health News:NoteSwift Joins Allscripts Developer Program 3Health News:Chicago Coffee Start-up Makes a Big Impact, Earns National Recognition 2Health News:Pelican Water Supports Breast Cancer Awareness Month with Order Donations 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 2Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 3Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 4Health News:Internationally Respected Oxnard Dentist Concludes All-on-4™ Dental Implants Training Today 5
... syndrome) has been a major killer in the last two ... worldwide and infected a further 8,000. A collaborative group of ... past year screening more than 8,000 existing drugs to find ... 15 existing drugs that have the potential to kill the ...
... the womb of the mother, may have asthma at a ... an 11-year observation of incidence of asthma and other respiratory ... to incidence of asthma in childhood. Passive smoking by the ... of asthma in children. ,Researchers are of the opinion ...
... Parkinson's disease is a neurodegenerative disease of the substantia nigra ... first discovered and its symptoms documented in 1817 by the ... in the brain of patients were identified in the 1960s. ... a mystery. , ,In a study done recently it ...
... have found sections of the // chromosomes of lung ... ,In a study in the July 1 issue ... nucleotide polymorphism (SNP) array technology, which focuses on the ... chromosomes where genes were either left out or multiplied ...
... autistic children have led to a fear in the world ... epidemic. However a recent report, which was published in the ... is not true. The report points out to certain facts ... ,The study had pointed out that recent changes in the ...
... that walking on a cobblestone mat surface resulted in ... physical performance among the age groups of 60 and ... said that Compared to conventional walking, the experience ... manufactured cobblestone mats improved participants' balance, measures of mobility, ...
Cached Medicine News:Health News:Re –growing Brain cells destroyed by Parkinson’s disease 2Health News:Possible location of lung cancer genes found 2Health News:Cobblestone Walking May Be The Key For Healthy Living. 2
(Date:9/30/2014)... Mass. , Sept. 30, 2014  Hologic, Inc. ... Stephen MacMillan , Hologic,s President and Chief Executive Officer, ... Ceremony on October 1, the first day of Breast ... discuss the Company,s campaign focused on the important benefits ... approved by the FDA as clinically superior to traditional ...
(Date:9/30/2014)... , Sept. 30, 2014 This ... for molecular imaging informatics solutions including nuclear imaging ... and comparison. The study assesses the size of ... 2010 and 2013, and projects future growth based ... as the dynamics taking place in the broader ...
(Date:9/30/2014)... , Sept. 30, 2014 Aileron Therapeutics, ... Summary Global Markets Direct,s, ,Aileron Therapeutics, Inc. ... overview of the Aileron Therapeutics, Inc.,s pharmaceutical research ... information on the current therapeutic developmental pipeline of ... various stages, therapeutics assessment by drug target, mechanism ...
Breaking Medicine Technology:Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 3Analysis of the US Molecular Imaging Informatics Market 2Analysis of the US Molecular Imaging Informatics Market 3Aileron Therapeutics, Inc. - Product Pipeline Review - 2014 2Aileron Therapeutics, Inc. - Product Pipeline Review - 2014 3
... nationally recognized, certified practice management and electronic ... its annual Customer Conference at the Magic City,s renowned ... A record 361 attendees registered for this ... last year,s figures. "Spotlight on Success" was chosen as ...
... RIDGEFIELD, Conn., May 19, 2011 Boehringer Ingelheim ... (dabigatran etexilate mesylate) capsules has received preferred ... Part D plans through its pharmacy benefits manager, ... include AARP Medicare Rx and AARP MedicareComplete from ...
Cached Medicine Technology:SuccessEHS "Spotlight on Success" Customer Conference Begins 2Pradaxa® (dabigatran etexilate mesylate) Capsules Gains Preferred Formulary Status with AARP®, Nation's Largest Provider of Medicare Part D Coverage 2Pradaxa® (dabigatran etexilate mesylate) Capsules Gains Preferred Formulary Status with AARP®, Nation's Largest Provider of Medicare Part D Coverage 3Pradaxa® (dabigatran etexilate mesylate) Capsules Gains Preferred Formulary Status with AARP®, Nation's Largest Provider of Medicare Part D Coverage 4Pradaxa® (dabigatran etexilate mesylate) Capsules Gains Preferred Formulary Status with AARP®, Nation's Largest Provider of Medicare Part D Coverage 5Pradaxa® (dabigatran etexilate mesylate) Capsules Gains Preferred Formulary Status with AARP®, Nation's Largest Provider of Medicare Part D Coverage 6