Navigation Links
Fox Chase researchers develop a screen for identifying new anticancer drug targets
Date:4/5/2011

ORLANDO, FL (April 5, 2011) Tumor suppressor genes normally control the growth of cells, but cancer can spring up when these genes are silenced by certain chemical reactions that modify chromosomes. Among the most common culprits responsible for inactivating these genes are histone deacetylases, a class of enzymes that remove acetyl groups from DNA-scaffolding proteins, and DNA methyltransferases, a family of enzymes that add methyl groups to DNA.

Drugs that counteract these enzymes, and thus reactivate tumor suppressor genes, are promising cancer therapies. For example, histone deacetylase inhibitors have been approved for the treatment of a type of T cell lymphoma, and are being tested in clinical trials for the treatment of a wide range of cancers. Similarly, DNA methyltransferase inhibitors have been approved to treat a certain kind of leukemia, and are undergoing clinical studies for the treatment of other cancers. But these medications can have serious side effects. Now, Fox Chase Cancer Center postdoctoral associate Andrey Poleshko, PhD, along with Research Professor Richard A. Katz, PhD, and their colleagues have developed a screen to identify proteins that work in conjunction with these enzymes to repress gene expression. They will present their results at the AACR 102nd Annual Meeting 2011 on Tuesday, April 5.

Finding additional proteins that inactivate tumor suppressor genes, and understanding how they work, could lead to the broadening of this class of therapies beyond the two enzyme families, Poleshko said. "If we can find a way to block the action of such proteins, it may be possible to reactivate aberrantly silenced tumor suppressor genes and restore controlled growth in certain cancer cells," he noted. Such an approach would avoid interfering directly with the vital chromosome-modifying enzymes.

The researchers genetically programmed human cells to glow fluorescent green upon reactivation of the silent genes they harbo
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Hollywood-Style Liposuction Comes to DC: Chevy Chase Smartlipo Brings Revolutionary Laser-Assisted Liposuction to DC Metro Area
2. Torchmark Corporation Declares Dividend and Resumes Stock Repurchases
3. International Merchant Advisors to Complete Purchase of Medical Marijuana Company Organic Science, Inc.
4. Grand Opening of LIFE Ionizer Australia Launches with a Free Ionizer Upgrade with Purchase of Alkaline Water Ionizer from LIFE Ionizer Australia
5. A New Twist On Convert to Purchase
6. Ensemble Healthcare Properties Purchases North Valley Medical Plaza
7. ARI Purchases Intercytex Assets
8. CapSite™ Provides Detailed Transparency on Healthcare Technology Purchases
9. Ivory Homes Plans Ahead for the April 30th Home Buyer Tax Credit Deadline with 100 New Homes Ready for Quick Purchase
10. R-Biopharm Group Purchases a Majority Ownership in Trilogy Lab, Expanding US Operations
11. Fox Chase clinical trial tests first of its kind antibody
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... York (PRWEB) September 01, 2014 Liver is ... one vital organ that helps the body in barring itself ... a store of energy. Liver also plays many important functions ... iron and glucose. , Many illnesses can affect the ... under the rib cage on the right side of the ...
(Date:9/1/2014)... 2014 More than 200 Lipitor lawsuit ... federal litigation that continues to progress in the U.S. ... reports. , A federal Case List published on ... widely-used cholesterol medication by plaintiffs who developed Type 2 ... Pfizer Inc. failed to adequately warn patients and their ...
(Date:9/1/2014)... Dennis Thompson HealthDay Reporter ... experimental Ebola drug previously given to two American aid workers ... virus in laboratory tests, researchers report. The drug, ZMapp, ... if they didn,t get the medication until five days after ... Ebola who were days or even hours away from death, ...
(Date:9/1/2014)... Denham Springs, LA (PRWEB) September 01, 2014 ... Crisis Intervention Instructor training, Derek is currently pursuing counselor ... been able to advance through the CPI training program ... Derek states "and I have grown both personally and ... addicts permanently recover, I am competently able to do ...
(Date:9/1/2014)... 2014 Bioinformatics refers to an ... biological and genetic data. A major part of ... software tools to generate and process useful biological ... biological computation. While bioinformatics simply makes use of ... its related concepts, biological computation refers to the ...
Breaking Medicine News(10 mins):Health News:Global Liver Diseases and Therapies Market- The Key Basics by Transparency Market Research 2Health News:Global Liver Diseases and Therapies Market- The Key Basics by Transparency Market Research 3Health News:South Carolina Litigation Adds 200 Lipitor Lawsuits in a Month, as Plaintiffs File Suits Alleging New-Onset Diabetes, Bernstein Liebhard LLP Reports 2Health News:South Carolina Litigation Adds 200 Lipitor Lawsuits in a Month, as Plaintiffs File Suits Alleging New-Onset Diabetes, Bernstein Liebhard LLP Reports 3Health News:Monkey Trial Supports Ebola Drug That May Have Helped 2 Stricken Americans 2Health News:Monkey Trial Supports Ebola Drug That May Have Helped 2 Stricken Americans 3Health News:Narconon Louisiana Announces New Certifications For Staff 2Health News:Bioinformatics Market: A fusion of Computers and Biological Data 2Health News:Bioinformatics Market: A fusion of Computers and Biological Data 3Health News:Bioinformatics Market: A fusion of Computers and Biological Data 4
... can cause liver or stomach illness in certain ... News) -- Many over-the-counter painkillers and fever reducers ... potential danger of liver damage and stomach bleeding, ... have to include these warnings on all their ...
... DURECT Corporation,s (Nasdaq: DRRX ) first quarter 2009 ... the conference call that will be broadcast live over the ... Time (1:30 pm Pacific Time).A live audio webcast of the ... http://www.durect.com and clicking "Investor Relations." ...
... Encryption business continues to drive performance for CompanyDALLAS, April ... ), the leader in hosted services for email encryption ... first quarter ended March 31, 2009. ZixCorp recorded ... net loss of $1.5 million for the quarter, or ...
... Specter (?-Penn) switched political parties from Republican to Democrat. Tom ... arm of Family Research Council, had this to say:"Senator Specter,s ... old saying, ,if it looks like a donkey, quacks like ... is probably a donkey., This holds true for Senator ...
... is a risk for a catastrophic pandemic -FLEMINGTON, N.J., ... physicians revealed that a majority of physicians (63%) reported ... Swine Flu will result in a worldwide catastrophic pandemic.(Logo: ... was conducted by HCD Research and the Muhlenberg ...
... Aid IllinoisCHICAGO, April 28 The Third Annual ... continuing impact that AmeriCorps volunteers are having across ... volunteers serving in Illinois this year, assisting at-risk ... for low-income families, and assisting nonprofits in volunteer ...
Cached Medicine News:Health News:FDA Adds New Label Warnings to Over-the-Counter Painkillers 2Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 2Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 3Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 4Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 5Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 6Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 7Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 8Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 9Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 10Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 11Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 12Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 13Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 14Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 15Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 16Health News:Zix Corporation Reports Highest Revenue Quarter as Company Announces First Quarter 2009 Financial Results 17Health News:Swine Flu Outbreaks Cause Concern among U.S. Physicians 2Health News:Swine Flu Outbreaks Cause Concern among U.S. Physicians 3Health News:Third Annual AmeriCorps Week 2Health News:Third Annual AmeriCorps Week 3
(Date:8/29/2014)... , Aug. 29, 2014   Vittamed Corporation , a ... announced today that T. (Teo) Forcht Dagi , ... company,s Board of Directors. " Teo Forcht ... in neurosurgery, medical innovation and venture capital," said Remis ... delighted to add his clinical, strategic, and entrepreneurial expertise to ...
(Date:8/29/2014)... , Aug. 29, 2014 Research and ... "Global Multiple Sclerosis Drugs Market 2014-2018" report to ... chronic, inflammatory medical condition that results in demyelination, axonal ... of an abnormal response by the immune system, which ... is a potentially debilitating disease in which the damage ...
(Date:8/29/2014)... August 29, 2014 Pixcelldata, the ... software has announced a major new deal with Dutch ... renowned pathology expert, Dr. Marius Nap . ... 26th European Congress of Pathology which is taking placing ... Arena, London where Pixcelldata will ...
Breaking Medicine Technology:Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2
... April 14, 2011 Reportlinker.com announces that a new ... Neuropathy Therapy Area Pipeline Report ... Area Pipeline Report contains detailed information on the neuropathy ... status of neuropathy drugs by company and by stage ...
... 14, 2011 Reportlinker.com announces that a new ... Juvenile Rheumatoid Arthritis (JRA) Therapeutics ... http://www.reportlinker.com/p0479828/Juvenile-Rheumatoid-Arthritis-JRA-Therapeutics---Pipeline-Assessment-and-Market-Forecasts-to-2017.html ... and Market Forecasts to 2017 ...
Cached Medicine Technology:Reportlinker Adds Neuropathy Therapy Area Pipeline Report 2Reportlinker Adds Neuropathy Therapy Area Pipeline Report 3Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 3Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 4Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 5Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 6Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 7Reportlinker Adds Juvenile Rheumatoid Arthritis (JRA) Therapeutics - Pipeline Assessment and Market Forecasts to 2017 8
... Injection molded chambers are seamless eliminating the possibility ... The Primo tanks have temperature resistant gel trays ... pour you gels. For added user friendliness, the ... UV fluorescent rule. The Primo Gel Systems ...
... up and safe to use, the Gel XL ... and running agarose gels. The unit is compact, ... power supply eliminates a tangled mess of leads ... Designed for safety and convenience, the power supply ...
... 33 Mini Submarine Unit for nucleic acid analysis in ... for very fast separations of DNA restriction fragments in ... heat-sink. Fill the base with coolant and seal. Precool ... the unit in a freezer or by immersing it ...
... 2000 apparatus and ready-to-use gels are the ... of nucleic acids by submerged gel electrophoresis. ... system, offering full compatibility and optimal performance, ... SEA 2000 and a unique staining tray, ...
Medicine Products: