Navigation Links
Fox Chase finds all-biologic regimen efficacious and well-tolerated in elderly lung cancer patients
Date:8/1/2009

SAN FRANCISCO (August 1, 2009)Previously untreated non-small cell lung cancer (NSCLC) patients over the age of 70 respond well to a combination of bevacizumab and erlotinib, Fox Chase Cancer Center researchers reported today at the annual meeting of the International Association for the Study of Lung Cancer.

"Based on our initial data, the combination appears to be well tolerated and efficacious, though we'll have to wait and see the final results," says Hossein Borghaei, D.O., medical oncologist at Fox Chase, who led the trial.

Elderly patients are often excluded from clinical trials because researchers fear they will have trouble tolerating standard chemotherapy regimens. That leaves open the question of how best to treat these individuals who account for more than half of all NSCLC in the United States.

With that challenge in mind, Borghaei and colleagues designed a trial testing a combination of two molecularly targeted agents in patients 70 years or older. The team reasoned that a combination lacking standard cytotoxic agents may be better tolerated by these patients, potentially without comprising efficacy. "We looked for a regimen that had few side effects, would involve only targeted agents, and had a bit of a track record. This combination was a natural fit," Borghaei says. Several small phase II trials in younger NSCLC patients demonstrated that the combination had anti-tumor activity and a relatively favorable toxicity profile.

Thus far 21 elderly NSCLC patients have enrolled in the Fox Chase trial and 14 are evaluable for response. The median age of the 14 evaluable patients is 78, with a range of 71 to 84 years. Four patients have had partial responses with demonstrable tumor shrinkage and three patients had stable disease by RECIST criteria.

The combination appears safe and well tolerated in this patient population with the most commonly encountered toxicities of clinical relevance being high blood pre
'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MaxLife Fund Corp. purchases a portfolio of Life Settlement Policies with a face value of $4,000,000
2. Northstar Healthcare Announces Option to Purchase a 60% Interest in The Palladium for Surgery - Dallas
3. Tyco International Increases Quarterly Dividend 36 Percent to 15 Cents per Share; Initiates New $1 Billion Share Repurchase Program
4. Consumer Group: Hillary Clintons Mandatory Health Insurance Purchase Plan is an Act of War on the Middle Class Family That Cant Afford $12k Policy
5. Kensey Nash Announces $25 Million Stock Repurchase Program
6. Nunez and Legislators Urged to Oppose Mandatory Purchase of Private Health Insurance
7. Flextronics Announces Redemption and Change of Control Repurchase Offer for Solectron 8.00% Senior Subordinated Notes and Planned Change of Control Repurchase Offer for Solectrons 0.50% Senior Convertible Notes
8. First Nationwide Class Action Filed on Behalf of Consumers Who Purchased Topps E. Coli Contaminated Ground Beef
9. Hospital Corporation of America Purchases Seventh CyberKnife(R) System
10. Dixtal Medical Purchases Novametrix Pulse Oximetry Business from Respironics
11. Governor Schwarzeneggers Mandatory Purchase of Private Health Insurance Doesnt Add Up for the Middle-Class, Says FTCR
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... virus caused the first flu pandemic in the 21st ... killed more than 50 people in the country. Since ... epidemics (winter/spring seasons). , Infections with influenza pH1N1 ... Health Organization has recommended Tamiflu for treatment of patients ... drug is that it targets viral proteins which mutate ...
(Date:4/23/2014)... unrelated donors was safe and effective in treating ... Clostridium difficile , according to a new pilot ... and available online. Known as fecal microbiota transplantation, ... a colonoscope or a nasogastric tube. The findings ... more readily available to patients. , A growing ...
(Date:4/23/2014)... SPOKANE, Wash.Researchers at Washington State University Spokane have ... are about to nod off behind the wheel. ... steering wheel movementswhich are more variable in drowsy ... to currently available video-based driver drowsiness detection systems. ... detect when a car is drifting out of ...
(Date:4/23/2014)... The American Society for Radiation Oncology (ASTRO) has ... Radiation Therapy for Endometrial Cancer: An ASTRO Evidence-Based ... therapy in the treatment of endometrial cancer. The ... 2014 issue of Practical Radiation Oncology ... The full-length guideline is available as an open-access ...
(Date:4/23/2014)... identified an important enzyme pathway that helps prevent new ... a condition that has been directly linked to cancer ... biochemistry, found that near the end of cell division, ... any breaks in DNA are fully repaired before the ... cells. This process helps safeguard against some of the ...
Breaking Medicine News(10 mins):Health News:Pilot study suggests ways to widen access to fecal transplants for C. diff infections 2Health News:WSU innovation improves drowsy driver detection 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3Health News:Study identifies enzymes that help fix cancer-causing DNA defects 2
... A ... by alcohol, according to Washington, D.C., personal injury attorney Mike Abelson. , ... Washington, D.C. (PRWEB) July 4, 2010 -- There ... Mike Abelson says. But on the holiday day designated to celebrate the freedoms ...
... ... Software, Today Announced That It Has Been Selected As A 2010 Emerging Technology Vendor By ... Philadelphia, PA ... software, today announced that it has been selected as a 2010 Emerging Technology Vendor by ...
... ... loss camp in the country, points out how how fantasy and reality don,t always mesh in ... new show "Huge". , ... (PRWEB) July 4, 2010 -- If it weren,t for a bit of fantasy, our lives would ...
... ... esteemed psychiatrist Dr. Lyubov Gorelik into the pages thier exclusive medical directory, The Leading ... a leader in psychiatry, and will be featured alongside other top physicians from around ... ...
... Reporter , THURSDAY, July 1 (HealthDay News) -- Complications ... can shorten the lives of patients by an average ... already shown that post-stroke complications increase mortality as well ... associate professor in the department of neurology at Ilsan ...
... ... Oxford House , ... 3, 2010 -- “Oxford House is a true blessing for those who really want recovery.” This ... Today, author Joe Chavez shares their stories in I Second The Motion: Learning to Live Sober, ...
Cached Medicine News:Health News:Don't Drink and Drive on Fourth of July Weekend, Washington, D.C., Attorney Warns 2Health News:Neuxpower Selected as 2010 Emerging Technology Vendor by CRN Magazine 2Health News:Real Life "Fat Camp" Owner Disagrees With How Such Camps Are Depicted In ABC Family's new show, "Huge" 2Health News:Real Life "Fat Camp" Owner Disagrees With How Such Camps Are Depicted In ABC Family's new show, "Huge" 3Health News:Renowned Psychiatrist, Lyubov Y Gorelik, M.D., is selected to represent New York in The Leading Physicians of the World 2Health News:Complications Shorten Stroke Patients' Lives 2Health News:Complications Shorten Stroke Patients' Lives 3Health News:Oxford House: Where Stories of Recovery Are Born 2
(Date:1/15/2014)... FRANKLIN, Ohio , Jan. 15, 2014  A novel wearable ... it easy and painless for patients to self-inject prescription drugs ... of disorders, including cancer, blood diseases, autoimmune deficiencies, and genetic ... expected to grow to $220B by 2018, according to analysts.   ...
(Date:1/14/2014)... Healthcare Services, Inc. ("DHS"), a portfolio company of GMH Ventures ... Equipment, Inc. ("Progressive") of Clarion, PA ... not disclosed. Progressive is a full service ... sleep, mobility, and respiratory products to customers in the western ...
(Date:1/14/2014)... N.Y. , Jan. 14, 2014   Oligomerix, Inc. , ... modifying therapeutics for Alzheimer,s disease (AD) and related neurodegenerative ... to Valhalla, NY as of ... laboratory space at New York Medical College. ...
Breaking Medicine Technology:Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... MEETING, Pa., Nov. 8, 2010 Keeping radiation ... hospitals, particularly in computed tomography (CT), which has undergone some ... side is that CT delivers some of the highest radiation ... measures for delivering the appropriate radiation dose can result in ...
... Biotechnologies Corporation, a leader in the emerging field of ... financial support for the company,s lead oncology product, Rexin-G, ... Services (HHS), and the National Institutes of Health (NIH) ... latest support for the clinical advancement of Rexin-G comes ...
Cached Medicine Technology:ECRI Institute Service to Address CT Radiation Dose Safety 2ECRI Institute Service to Address CT Radiation Dose Safety 3Epeius Biotechnologies Awarded Federal Grant Advancing Tumor-Targeted Cancer Therapy 2
FM Style Neonatal Flowmeters (Brass Body)...
... features for the professional ophthalmic photographer. Integrated ... and background illumination, all controlled through a ... joystick, as well as adaptors allowing for ... range professional level digital and 35 mm ...
... The system that makes it all ... Biology Workstation is an automated multi-purpose ... sequences, such as in the analysis ... Short Tandem Repeats (STRs) using the ...
Assess serum Gc-globulin levels in patients with multiple trauma, fulminant liver failure, acetaminophen overdose, and sepsis....
Medicine Products: