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Founding Father of Modern Cosmetic Dermatology Seeks to Warn Public of Misrepresented Data and Inappropriate Use of Botox
Date:3/6/2008

BEVERLY HILLS, Calif., March 6 /PRNewswire/ -- World-renowned dermatologist, Dr. Arnold Klein, is on a mission to inform the public about the dangers surrounding one of the most popular injectable cosmetic agents: Botox. According to Forbes.com, Botox is the second-most recognized prescription drug brand in the world behind Viagra. Klein says that in many instances, the use of Botox has replaced traditional surgery. "To properly use this," Klein continued, "physicians need to be properly trained and educated and the U.S. Food and Drug Administration needs to be far more aggressive in protecting the public," Klein said. "Not only is there evidence of misuse and improper administration of Botox," Klein continued, "there is additional evidence of misrepresentation of data by Botox manufacturer Allergan."

In 2003, Dr. Klein reviewed a study submitted by foreign doctors working for Allergan to the American Society of Dermatologic Surgery's journal Dermatologic Surgery regarding the dilution of Botox. The author was trying to show that certain dilutions of the Botox formula would not significantly detract from the product's safety and efficacy. "A review of the paper uncovered serious problems with the manuscript, including graphs demonstrating a worsening of wrinkle severity after the Botox wore-off," revealed Klein. Based on these problems the study was denied publication. The author then resubmitted the study with different data. Dr. Klein alerted the editor of Dermatologic Surgery to this highly suspect data change. Dr. Klein was assured that this problem would be resolved.

"Ultimately, this same study appeared anyway two years later in a special Allergan sponsored edition of Dermatology Surgery with the altered data," charged Klein. According to Klein, the data that was published was changed to support the author's original claims, and was never part of the study that he and several other doctors reviewed. "Needless to say I have serious problems
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SOURCE Arnold William Klein MD
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