Navigation Links
Foreign multidrug resistant bacteria contained in Toronto hospital

CHICAGO (December 11, 2012) As the prevalence of antibiotic-resistant infections continue to rise around the world, a hospital in Canada detected the presence of New Delhi Metallo--lactamase-1-Producing Klebsiella pneumoniae (NDM1-Kp), a multidrug resistant bacteria that is resistant to carbapenems, one of the last lines of antibiotics. The retrospective report, featured in the January issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America, analyzes risk factors and infection control strategies taken to prevent the spread of NDM1-Kp.

NDM1-Kp is common in other parts of the world such as the Indian subcontinent, but rare in North America except for imported cases from patients previously hospitalized in endemic regions.

Between January 2011 and March 2012, seven patients at a tertiary care teaching hospital in Toronto acquired NDM1-Kp from two index patients. Risk factors for acquisition were a history of prior use of certain antibiotics, and transmission likely occurred through direct contact. Four of the seven were roommates with an affected patient, two were on the same ward, and one was admitted to a room immediately following the discharge of an infected patient. The environmental sources of transmission highlight the importance of maintaining meticulous cleaning, hand hygiene, and disinfection standards in prevention and containment.

"The spread of the NDM1-Kp is an emerging public health threat, as increased globalization may result in a higher burden of these bacteria in Canada and other countries than previously recognized," said lead researcher Christopher F. Lowe, MD. "Preventing the spread of this organism in hospitals is critical given the lack of effective antibiotics against NDM1-Kp."

When a patient was identified with NDM1-Kp at the hospital, they were placed on contact precautions for the duration of their admission, as recommended by the CDC and Public Health Agency of Canada. At the Toronto hospital, contacts such as roommates or ward mates were screened 3 times over a 2 week period to see if transmission had occurred. During the screening period, the patients were also placed into contact precautions and private rooms until all three screenings were negative. Unfortunately, staff discovered that several contacts with negative screens subsequently became positive for NDM1-Kp weeks later.

Challenges in fighting the spread of NDM1-Kp include contacts who acquire the bacteria, but may initially have a low concentration of organisms and avoid detection, as well as the lack of an established gold standard to detect carbapenem-resistant organisms, which may have contributed to the negative screens. Although the isolation of NDM1-producing bacteria is currently a rare occurrence in healthcare settings, this cluster indicates the prevalence of these organisms is increasing in nonendemic regions, and prompt initiation of infection prevention and control practices is essential to prevent transmission.


Contact: Kate Enos
Society for Healthcare Epidemiology of America

Related medicine news :

1. Kinase test may yield big gains for drug-resistant cancers
2. New drug strategy attacks resistant leukemia and lymphoma
3. Einstein awarded $6 million grant to develop new TB vaccine against drug-resistant strains
4. New Medicine Might Fight Drug-Resistant TB, Study Says
5. Antibiotic-Resistant Gonorrhea Spreading: WHO
6. Rare Drug-Resistant Bacteria Spotted in U.S. Hospital
7. Scientists develop new strategy to overcome drug-resistant childhood cancer
8. Abuse-Resistant Oxycontin May Be Driving Addicts to Heroin
9. A new route for tackling treatment-resistant prostate cancer
10. Computational analysis identifies drugs to treat drug-resistant breast cancer
11. Treating drug resistant cancer through targeted inhibition of sphingosine kinase
Post Your Comments:
(Date:12/1/2015)... ... ... ClinicoEconomics and Outcomes Research has published the ... ”. , As corresponding author Dr Ankita Modi says “Pre-existing gastrointestinal events may ... a large US managed care database, women aged 55 years or older with ...
(Date:12/1/2015)... ... December 01, 2015 , ... Physicians’ Education Resource®, ... (CME), today announced that the first annual School of Gastrointestinal Oncology™ (SOGO™) will ... detection and treatment of gastrointestinal cancers are undergoing transformational change, providing oncologists with ...
(Date:12/1/2015)... (PRWEB) , ... December 01, 2015 , ... Growth in ... part due to decreases in utilization of hospital and nonhospital care, according to a ... CompScope™ Medical Benchmarks for Louisiana, 16th Edition , found medical payments per claim with ...
(Date:12/1/2015)... , ... December 01, 2015 , ... ... medical images have been lifted as IMAGE Information Systems launches MED-TAB™ -- the ... North America Annual Meeting from November 29 to December 4, 2015. , ...
(Date:12/1/2015)... ... December 01, 2015 , ... Visage ... (“Visage”), a wholly owned subsidiary of Pro Medicus Ltd. (ASX: PME), has announced ... Radiological Society of North America (RSNA) 2015 annual meeting through December 3 in ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)... 2015 Breg, Inc ., a premier ... that it has been awarded three contracts by Novation, ... Novation will have access to improved pricing for Breg,s ... soft goods dedicated to advancing orthopedic care.  ... U.S. population, rising prevalence of chronic conditions and the ...
(Date:12/1/2015)... , December 1, 2015 Russia ... III clinical trials. 70% of new drugs registered in Europe ... in Russia . --> Russia has always ... 70% of new drugs registered in Europe in ... --> Russia has always been a ...
(Date:12/1/2015)... 1, 2015 CytRx Corporation (NASDAQ: CYTR ... oncology, today announced that it has reached its enrollment ... Phase 3 clinical trial of aldoxorubicin in patients with ... to be completed in Q1 2016. The Phase 3 trial ... Special Protocol Assessment from the FDA at 79 sites ...
Breaking Medicine Technology: