Navigation Links
For embolism patients, clot-busting drug is worth risk
Date:2/21/2013

EAST LANSING, Mich. --- When doctors encounter a patient with a massive pulmonary embolism, they face a difficult choice: Is it wise to administer a drug that could save the patient's life, even though many people suffer life-threatening bleeding as a result?

Based on new findings published in the American Journal of Medicine, Michigan State University researchers are answering that question in no uncertain terms.

"The message to doctors is clear: Take the chance," said Paul D. Stein, a professor in MSU's Department of Osteopathic Medical Specialties. "It doesn't matter how old the patient is or what other chronic diseases the patient has. Administering the drug saves lives."

Pulmonary embolism is a potentially deadly blockage of arteries in the lungs caused by blood clots that travel from elsewhere in the body, usually the leg. Clot-dissolving drugs known as thrombolytic agents often can remove the blockage, but they also can cause brain hemorrhages and other major bleeding.

Stein found in an earlier study that only about a third of unstable pulmonary embolism patients -- those who are in shock or require a ventilator -- received thrombolytic therapy, even though the drugs decreased the risk of dying in the hospital from 50 percent to 15 percent.

"Doctors are smart," Stein said, "so why are only a third of patients getting the drug?"

To find out, Stein and Fadi Matta, MSU associate professor of osteopathic medical specialties, reviewed a national database of records from more than 1,000 hospitals. Their findings suggest that concern over the bleeding associated with thrombolytic therapy may keep doctors from giving the drug to patients who could be at higher risk.

In the study, only 20 percent of unstable patients with associated chronic conditions received the drug, compared to 80 percent of those without such conditions. Patients older than 60 also were less likely to receive the treatment.

Yet, even if patients had associated chronic conditions in addition to pulmonary embolism, the in-hospital death rate was 20 percent among those who received thrombolytic therapy, compared to 47 percent of those who did not get the clot-dissolving drug. The death rate also was lower among elderly patients who got the drug.

"Physicians apparently are afraid to give thrombolytic drugs to pulmonary embolism patients if they are elderly or have associated illnesses, and for good reason," Stein said. "Bleeding can be severe with such drugs, but the fact is, a lot more patients die if they don't get the drug than if they do."


'/>"/>

Contact: Andy McGlashen
andy.mcglashen@cabs.msu.edu
517-355-5158
Michigan State University
Source:Eurekalert

Related medicine news :

1. US Drug Watchdog Now Urges Yaz Yasmin Birth Control Pill Users Who Suffered a Pulmonary Embolism or Other Serious Medical Issues to Call the Johnson Law Group-ASAP
2. US Drug Watchdog Now Urges Yaz Yasmin Birth Control Pill Users Who Suffered a Pulmonary Embolism or a Heart Attack to Call the Johnson Law Group Now-Before Time Runs Out
3. The US Drug Watchdog Now Warns Time Could Run Out to Get Women Yaz or Yasmin Birth Control Pill Users Identified if they Suffered a Heart Attack Stroke or a Embolism
4. Doctors fail to communicate impact of heart devices with patients, SLU study finds
5. For stroke patients, mechanical clot removal delivers no advantage over standard care
6. TraceLink Life Sciences Cloud Named Amazon AWS Grand Prize Winner for Protecting Patients, Enabling Health, Ensuring Track and Trace Compliance
7. Trauma patients, community say they support exception from informed consent research
8. New Association Created to Advocate for Medical Marijuana Patients, Dispensary Operators and Advocates
9. Doctors Often Miss Signs of Problem Drinking in Patients, Study Finds
10. Get New Patients, INC Releases New Infographic titled 'Are Negative Reviews Killing Your Medical Practice?"
11. Author of the Uplifting Cancer Survival Guide, The C Card and Me, Opens Online Shop with Inspiring Gifts for Cancer Patients, Survivors and Caregivers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Fairfax, VA (PRWEB) , ... October 13, 2017 ... ... provider of DevOps and Agile Software Development, has been awarded a contract by ... (EATS) Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... are now treating sleep apnea using cutting-edge Oventus O2Vent technology. As ... serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics ... PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... of Morris F. Collen, a pioneer in the field of medical informatics, this prestigious ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader ... a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were ... 11, 2017. , The annual award competition recognizes editorial and design excellence across a ...
(Date:10/12/2017)... ... 2017 , ... Health Literacy Innovations (HLI), creator of the ... the Cancer Patient Education Network (CPEN), an independent professional organization that shares best ... alliance. , As CPEN’s strategic partner, HLI will help support CPEN members ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare ... CPR training aide "cprCUBE" on Kickstarter. The device will ... during cardiac arrests with better efficiency compared to the ... offers real-time feedback on efficacy of the compression for ... campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... -- Eli Lilly and Company (NYSE: LLY ) ... of 2017 on Tuesday, October 24, 2017. Lilly will ... the investment community and media to further detail the ... begin at 9 a.m. Eastern time. Investors, media and ... the conference call through a link that will be ...
Breaking Medicine Technology: