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For depression, relapsers go to the front of the brain
Date:8/22/2011

sing visual information. Responses in this visual area were also linked to greater feelings of acceptance and non-judgment of experience. Both the frontal and visual responses to sadness were atypical, in that they were not found in people who had never been depressed.

"Despite achieving an apparent recovery from the symptoms of depression, this study suggests that there are important differences in how formerly depressed people respond to emotional challenges that predict future well-being," explained author Dr. Norman Farb. "For a person with a history of depression, using the frontal brain's ability to analyze and interpret sadness may actually be an unhealthy reaction that can perpetuate the chronic cycle of depression."

Dr. John Krystal, editor of Biological Psychiatry added, "Relapse is one of the most vexing problems in depression treatment. Having a biomarker for relapse could guide a new generation of treatment research."

Further evaluation is needed to determine whether the brain's reaction to sadness can predict a person's risk for future depression on an individual, case-by-case basis. It will also be important to examine whether people identified as being at risk for relapse can be trained to change their way of responding to negative emotion or whether treatment strategies can be developed that would target the hyperactivity of this cortical region when processing sad or other negative stimuli.


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Contact: Chris J. Pfister
c.pfister@elsevier.com
215-239-3266
Elsevier
Source:Eurekalert

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