Navigation Links
For depression, relapsers go to the front of the brain
Date:8/22/2011

Philadelphia, PA, August 22, 2011 - Depression is increasingly recognized as an illness that strikes repeatedly over the lifespan, creating cycles of relapse and recovery. This sobering knowledge has prompted researchers to search for markers of relapse risk in people who have recovered from depression. A new paper published in Elsevier's Biological Psychiatry suggests that when formerly depressed people experience mild states of sadness, the nature of their brains' response can predict whether or not they will become depressed again.

Patients who ruminate and activate the brain's frontal lobes are more likely to relapse into depression than those who respond with acceptance and activate visual areas in the back of the brain. Part of what makes depression such a devastating disorder is the high rate of relapse: each time a person becomes clinically depressed, increases their chances of becoming depressed by 16%. However, the fact that some patients are able to fully maintain their recovery points to the possibility that differences in the way they respond to everyday emotional challenges may reduce their chances of relapse.

Using functional magnetic resonance imaging to examine that possibility, researchers presented sixteen formerly-depressed patients with sad movie clips while taking pictures of their brain activity. Over the next year and a half, nine of the sixteen patients relapsed into depression. The researchers compared the brain activity of relapsing patients against those who remained healthy and against another group of people who had never been depressed. When faced with sadness, relapsing patients showed more activity in a frontal region of the brain known as the medial prefrontal gyrus. Responses in this frontal region were also linked to higher rumination scores, the tendency to think obsessively about negative events. Patients who did not relapse showed more activity in the rear part of the brain responsible for processing visual information. Responses in this visual area were also linked to greater feelings of acceptance and non-judgment of experience. Both the frontal and visual responses to sadness were atypical, in that they were not found in people who had never been depressed.

"Despite achieving an apparent recovery from the symptoms of depression, this study suggests that there are important differences in how formerly depressed people respond to emotional challenges that predict future well-being," explained author Dr. Norman Farb. "For a person with a history of depression, using the frontal brain's ability to analyze and interpret sadness may actually be an unhealthy reaction that can perpetuate the chronic cycle of depression."

Dr. John Krystal, editor of Biological Psychiatry added, "Relapse is one of the most vexing problems in depression treatment. Having a biomarker for relapse could guide a new generation of treatment research."

Further evaluation is needed to determine whether the brain's reaction to sadness can predict a person's risk for future depression on an individual, case-by-case basis. It will also be important to examine whether people identified as being at risk for relapse can be trained to change their way of responding to negative emotion or whether treatment strategies can be developed that would target the hyperactivity of this cortical region when processing sad or other negative stimuli.


'/>"/>

Contact: Chris J. Pfister
c.pfister@elsevier.com
215-239-3266
Elsevier
Source:Eurekalert

Related medicine news :

1. Childhood Depression, Anxiety Tied to Pain in Adulthood
2. Spiritual retreat can lower depression, raise hope in heart patients
3. Group therapy helps MS sufferers cope with depression, study finds
4. Antidepressants may not improve all symptoms of depression, UT Southwestern researchers find
5. Mexican Immigrants to U.S. Prone to Depression, Anxiety Disorders
6. Study Highlights How Moms Depression, Anger Stresses Kids
7. Peer Support Beats Usual Care for Depression, Analysis Finds
8. Video Game Addiction Tied to Depression, Anxiety in Kids
9. Study finds family acceptance of LGBT youth protects against depression, substance abuse, suicide
10. Depression, Anxiety May Raise Surgery Risks
11. Non-invasive therapy significantly improves depression, UCLA researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... , ... Sharon Kleyne, host of the nationally syndicated radio program, The Sharon ... America, declared on her radio program in November 2016 the need to educate people ... attack leaders in corporate America, they are trying to take advantage of successful algorithms ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... Facial plastic ... this holiday season by donating a portion of proceeds to two local organizations: North ... Chicago Animal Control & Friends is a team of authorized and trained volunteers ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... is condemning "scam operations" carried out by unethical locksmith companies and is urging ... to a halt. According to Texas Premier Locksmith, these fraudulent locksmith services take ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... The medical ... holidays and winter seasons. One major study analyzing heart attacks among 138,602 people ... August of a given year. We would all agree of course–no time of year ...
(Date:12/7/2016)... Ohio (PRWEB) , ... December 07, 2016 , ... ... in the 2016 BOC Business Brilliance Awards under the Best New Product Launch ... and results achieved through user experience. , BOC Global Events & Training Group ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... 6, 2016 Anaplastic Oligoastrocytoma - Pipeline ... Direct,s latest Pharmaceutical and Healthcare disease pipeline guide ... an overview of the Anaplastic Oligoastrocytoma (Oncology) pipeline ... that forms when two types of cells in ... in number to form a mass. These brain ...
(Date:12/6/2016)...   AlloSource , one of the nation,s ... soft-tissue allografts for use in surgical procedures, recognized ... being named to the Board of Examiners for ... the Commerce Department,s National Institute of Standards and ... excellence. The Baldrige Award is the nation,s highest ...
(Date:12/6/2016)...  BTL Aesthetics today announced the release of ... ME device was effectively redesigned for more efficient, ... tissue. The result: Significantly better outcomes in abdominal ... ME versus BTL Vanquish. "We are ... patients with the most highly-advanced devices on the ...
Breaking Medicine Technology: