Navigation Links
For children with sickle cell disease, lung disease is part of the package

ATS 2008, TORONTOChildren with sickle cell disease (SCD) have a significantly sharper decline in lung function with age when compared to other children of the same race and age. Furthermore, that loss of function appears to be linked to a restrictive rather than obstructive pattern, contrary to previous research that has focused on obstructive or asthma-like patterns in loss of lung function with sickle cell disease. The research will be presented at the American Thoracic Societys 2008 International Conference in Toronto on Sunday, May 18.

The restrictive pattern of decline is supportive of early injury or inflammation resulting in progressive changes in lung volumes across age, said lead researcher Joanna MacLean, M.D., of the department of respiratory medicine at Childrens Hospital at Westmead in Australia. We expected that children with sickle cell disease would show greater loss of lung function than other children, but this had never been quantified, nor was the pattern of decline clear.

To determine the patterns of loss of lung function, the researchers analyzed 1,357 lung function results that were completed between January 1989 and January 2005 on from 413 children with SCD during routine sickle cell clinical visits. Lung volume measurements were also included for 1,129 records.

They found that over time, there was a significant decline in lung function shown by a decline in the percent predicted values for all spirometry measures except FEV1/FVC ratio, a marker of airway obstruction. The pattern of decline of lung volume confirmed a restrictive pattern with an average loss of 2 percent per year of total lung capacity.

This is the first study to examine loss of lung function in children with sickle cell disease over time in a large number of children. Most studies of lung function in children with sickle cell disease are either cross-sectional or have limited longitudinal follow-up, said Dr. MacLean. The strength of our study is that data was collected from a large number of children with sickle cell disease across childhood.

They also found that of children with SCD, hemoglobin-beta genotype SS was associated with an increased risk of loss of lung function across childhood. The hemoglobin SS genotype is more common than hemoglobin SC genotype (one in 600 versus one in 800 life births) and is associated with more complications than hemoglobin SC disease. This pattern of decline in lung function may simply reflect a greater risk of lung injury in this group, but alternatively may also suggest differences in response to lung injury or lung repair with different genotypes of sickle cell disease.

Our findings confirm that lung disease in SCD begins in childhood, explained Dr. MacLean. Using statistical modeling, we are able to predict the rate of decline of lung function. These results can be used as a baseline against which results from intervention studies can be compared.

While changes in treatment over the last 20 years have led to a significant reduction in overall mortality and morbidity for children with SCD, prospective longitudinal studies focusing on the identification and treatment of sickle cell associated lung disease are needed to continue to improve the long term health of children and adults with sickle disease.

The results of this project emphasize the need for further investigation into the pathophysiology and treatment of lung disease in children with sickle cell disease, concluded Dr. MacLean.


Contact: Keely Savoie
American Thoracic Society

Related medicine news :

1. Children of depressed moms do better when dad is involved, SLU researcher finds
2. High pollution linked to poor lung function growth in children in Mexico City
3. NYC-area 1st: Morgan Stanley Childrens Hospital performs transcatheter pulmonary valve replacement
4. Obese Children Miss More School Days
5. Ultra-Runner to Run 63 Marathons in 63 Days for Children with Incurable Disease
6. Psoriasis Cure Now offers Back to School Resources for Parents of Children with Psoriasis
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Practice-based intervention has sustained benefits for children and families
10. 1.5 million children could be saved
11. Annual flu shot cuts need for doctors visits, hospitalization among children
Post Your Comments:
(Date:6/25/2016)... Miami, FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton ... Plant City Observer , brings up a new, often overlooked aspect of head lice: ... The closing for fumigation is not a common occurrence, but a necessary one in the ...
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from ...
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, ... Elite. The attorneys chosen by their peers for this recognition are considered among the ... Traurig Shareholders received special honors as members of this year’s Legal Elite Hall of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... Forecast to 2022" report to their offering. ... date financial data derived from varied research sources to present ... impact on the market during the next five years, including ... sub markets, regional and country level analysis. The report provides ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
Breaking Medicine Technology: