Navigation Links
For brain tumors, origins matter

Cancers arise when a normal cell acquires a mutation in a gene that regulates cellular growth or survival. But the particular cell this mutation happens inthe cell of origincan have an enormous impact on the behavior of the tumor, and on the strategies used to treat it.

Robert Wechsler-Reya, Ph.D., professor and program director at Sanford-Burnham Medical Research Institute, and his team study medulloblastoma, the most common malignant brain cancer in children. A few years ago, they made an important discovery: medulloblastoma can originate from one of two cell types: 1) stem cells, which can make all the different cell types in the brain, or 2) neuronal progenitor cells, which can only make neurons.

Stem cells and progenitor cells are regulated by different growth factors. So, Wechsler-Reya thought, maybe the tumors arising from these cells respond differently to different therapies

In a study published in the journal Oncogene, he and his team show that this is indeed the case. They looked at one growth factor in particularbasic fibroblast growth factor (bFGF)and found that while it induces stem cell growth, it also inhibits neuronal progenitor cell growth.

What's more, the researchers discovered that bFGF also blocks the growth of tumors that originate from progenitors. When they administered bFGF into a mouse model of medulloblastoma, it dramatically inhibited tumor growth.

Although bFGF itself can't be used as a drug (it would cause too many off-target effects), this study suggests that molecules like it might be used to treat medulloblastomabut only for tumors that have the appropriate origins.

"Medulloblastomas are not all alike, and the same is true for cancers of the breast, prostate and other tissues. It's critical for us to figure out how tumors differ from one another, so we can find ways to personalize cancer diagnosis and come up with treatments that are more effective and less harmful," Wechsler-Reya says.

Contact: Heather Buschman, Ph.D.
Sanford-Burnham Medical Research Institute

Related medicine news :

1. Should hyperbaric oxygen therapy be used to treat combat-related mild traumatic brain injury?
2. Meditation appears to produce enduring changes in emotional processing in the brain
3. Early Exposure to Stress at Home Affects Girls Brains, Study Says
4. New form of brain plasticity: Study shows how social isolation disrupts myelin production
5. Brain injury and stress disorder strong indicators of vision problems for veterans
6. Scientists uncover a new pathway that regulates information processing in the brain
7. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
8. ADHD medicine affects the brains reward system
9. Caffeine May Help the Brain Process Words
10. The brain of OCD sufferers is more active when faced with a moral dilemma
11. Inpatient brain injury education increases bike helmet use, study finds
Post Your Comments:
Related Image:
For brain tumors, origins matter
(Date:10/13/2015)... ... 2015 , ... Tempe Dental Care, a leading Tempe dentists’ office, celebrates offering ... dentistry for more than 5 years. A leading cause of emergency room visits, ... treatment is not timely. , Sedation dentistry provides an anxiety-free dental ...
(Date:10/13/2015)... ... ... According to an ESPN report published on October 1, Chicago ... him in the left eye during the first day of practice for the season ... of setbacks, including a knee injury that has interfered with his ability to stay ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... developed valuable new strategies for enrolling and serving insurance consumers who do not ... health insurance and pay monthly premiums. In “Health Plan Engagement Strategies: The ABCs ...
(Date:10/13/2015)... ... October 13, 2015 , ... Just under three months ... eMarketing Concepts began a $1 promotion – effectively offering all of their services for ... within weeks the company was flooded with phone calls from interested buyers. As a ...
(Date:10/13/2015)... ... , ... The Bill Howe Family of Companies is an award winning HVAC ... remediation services. Family-owned and operated for 35 years, they have maintained value, ethics and ... two years in a row from the Union Tribune Reader’s Poll, a Healthiest Company ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... 2015 Given the intricacy of the ... to deliver an ophthalmic drug effectively to a specific ocular ... ocular drug delivery. These include dilution of a drug by ... conjunctiva and drug permeation issues with respect to the cornea, ... eye drops, is lost due to the aforementioned barriers. ...
(Date:10/12/2015)... N.J. , Oct. 12, 2015  Shareholder rights ... a securities fraud class action complaint was filed in ... Jersey.  The complaint alleges that officers and directors of ... Act of 1934 between September 15, 2015 and October ... about Amicus Therapeutics, business prospects.  Amicus is a biopharmaceutical ...
(Date:10/12/2015)... 12, 2015  Millions of smokers worldwide have used ... of tobacco. An April 2015 study released ... showed electronic cigarettes to be up to 95 percent ... a decade after the technology was first introduced the ... --> --> Palm ...
Breaking Medicine Technology: