Navigation Links
For brain tumors, origins matter
Date:11/13/2012

Cancers arise when a normal cell acquires a mutation in a gene that regulates cellular growth or survival. But the particular cell this mutation happens inthe cell of origincan have an enormous impact on the behavior of the tumor, and on the strategies used to treat it.

Robert Wechsler-Reya, Ph.D., professor and program director at Sanford-Burnham Medical Research Institute, and his team study medulloblastoma, the most common malignant brain cancer in children. A few years ago, they made an important discovery: medulloblastoma can originate from one of two cell types: 1) stem cells, which can make all the different cell types in the brain, or 2) neuronal progenitor cells, which can only make neurons.

Stem cells and progenitor cells are regulated by different growth factors. So, Wechsler-Reya thought, maybe the tumors arising from these cells respond differently to different therapies

In a study published in the journal Oncogene, he and his team show that this is indeed the case. They looked at one growth factor in particularbasic fibroblast growth factor (bFGF)and found that while it induces stem cell growth, it also inhibits neuronal progenitor cell growth.

What's more, the researchers discovered that bFGF also blocks the growth of tumors that originate from progenitors. When they administered bFGF into a mouse model of medulloblastoma, it dramatically inhibited tumor growth.

Although bFGF itself can't be used as a drug (it would cause too many off-target effects), this study suggests that molecules like it might be used to treat medulloblastomabut only for tumors that have the appropriate origins.

"Medulloblastomas are not all alike, and the same is true for cancers of the breast, prostate and other tissues. It's critical for us to figure out how tumors differ from one another, so we can find ways to personalize cancer diagnosis and come up with treatments that are more effective and less harmful," Wechsler-Reya says.


'/>"/>
Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Related medicine news :

1. Should hyperbaric oxygen therapy be used to treat combat-related mild traumatic brain injury?
2. Meditation appears to produce enduring changes in emotional processing in the brain
3. Early Exposure to Stress at Home Affects Girls Brains, Study Says
4. New form of brain plasticity: Study shows how social isolation disrupts myelin production
5. Brain injury and stress disorder strong indicators of vision problems for veterans
6. Scientists uncover a new pathway that regulates information processing in the brain
7. Moffitt Cancer Center researchers identify novel metabolic programs driving aggressive brain tumors
8. ADHD medicine affects the brains reward system
9. Caffeine May Help the Brain Process Words
10. The brain of OCD sufferers is more active when faced with a moral dilemma
11. Inpatient brain injury education increases bike helmet use, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
For brain tumors, origins matter
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association ... it will receive two significant new grants to support its work to advance ... 25th anniversary by recognizing patients, medical professionals and scientists for their work in ...
(Date:6/24/2016)... ... ... makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum ... by 2020 and then adjusting it yearly to increase at the same rate as the ... wage floor does not erode again, and make future increases more predictable. , The company ...
(Date:6/24/2016)... Nevada (PRWEB) , ... June 24, 2016 , ... ... Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations ... in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, MTI-GlobalStem, a provider of ... other difficult to transfect cells, announces its launch of the PluriQ™ G9™ Gene ... System is a complete system for culturing and transfecting human pluripotent stem ...
(Date:6/24/2016)... ... June 24, 2016 , ... Southern ... DDS, are co-chairs for the Illinois State Dental Society (ISDS) Foundation’s Mission of ... the Gateway Convention Center in Collinsville. , They expect to treat ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CHAPEL HILL, N.C. , June 24, 2016 ... in healthcare decisions and regulators/payers have placed more ... this new environment, patient support programs in the ... support for patients, medications. Consequently, pharmaceutical companies are ... to ensure they are providing products and services ...
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... 24, 2016  Global Blood Therapeutics, Inc. (GBT) (NASDAQ: ... novel therapeutics for the treatment of grievous blood-based ... closing of its previously announced underwritten public offering ... public offering price of $18.75 per share. All ... by GBT. GBT estimates net proceeds from the ...
Breaking Medicine Technology: