Navigation Links
For Juvenile Arthritis, Pill May Work as Well as Needle
Date:5/31/2012

THURSDAY, May 31 (HealthDay News) -- Taking the arthritis drug methotrexate in pill form was just as effective as receiving it by injection for the long-term treatment of children with juvenile rheumatoid arthritis, a new study has found.

Since both methods also have a similar incidence of side effects, researchers said the findings suggest that children may as well take the medication as a pill instead of having to put up with the discomfort of injections.

They noted, however, that their study looked back at registry information on kids with arthritis. More research -- including controlled clinical trials, the gold standard of research -- is needed before making a treatment recommendation.

The study, published May 30 in the journal Arthritis Care & Research, was funded by drug maker Wyeth BioPharma.

Methotrexate (brand name Rheumatrex) is one of the most common first-line disease-modifying antirheumatic drug treatments for arthritis.

In this study, German researchers compared more than 150 patients who received methotrexate injections and more than 250 patients who took the drug orally. The male and female patients, who had a median age of 10, all received comparable doses.

After six months of treatment, nearly three-quarters of patients -- including 73 percent receiving injections and 72 percent receiving the pill form -- showed a response to the drug. At least one negative side effect was reported in 27 percent of those receiving injections and 22 percent of those on the oral drug.

Eleven percent of patients receiving injections stopped treatment due to negative side effects, compared with 5 percent of those on oral therapy, the researchers noted.

Juvenile rheumatoid arthritis, also called juvenile idiopathic arthritis, affects between 10 and 100 per 100,000 children younger than 16. It is the most common chronic inflammatory disease in children and can lead to severe disability. About 294,000 U.S. children have the disease, according to the American College of Rheumatology.

One expert in the United States agreed that methotrexate seemed to work equally well regardless of how the children received it.

"Methotrexate is one of the disease-modifying agents used to treat arthritis -- it can be taken as a pill or as a subcutaneous [under the skin] injection and pediatric rheumatologists have felt that the parenteral route (injection) has been the most efficacious," said Dr. B. Anne Eberhard, a pediatric rheumatologist at Cohen Children's Medical Center in New Hyde Park, N.Y. However, she added, "this study from Germany suggests otherwise."

Still, while some children did experience "significant improvement in their arthritis" with methotrexate, most patients "did not achieve remission in their illness, which is the ultimate aim in treating children with juvenile idiopathic arthritis," Eberhard noted.

More information

The Nemours Foundation has more about juvenile rheumatoid arthritis.

-- Robert Preidt

SOURCES: B. Anne Eberhard, M.D., pediatric rheumatologist, Cohen Children's Medical Center, New Hyde Park, N.Y.; Arthritis Care & Research, news release, May 30, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Injection of methotrexate not superior to oral therapy in juvenile arthritis treatment
2. Children with juvenile arthritis have higher rates of bacterial infection
3. Social workers should reclaim role in juvenile corrections system, MU researcher says
4. Study identifies factors linked with better medication response for treatment of juvenile arthritis
5. Sonography complements physical exam in identifying juvenile inflammatory arthritis in children
6. Better HIV prevention interventions needed for juvenile offenders
7. New clinical practice guidelines developed for juvenile idiopathic arthritis
8. Doctor Shortage Adds to Pain of Juvenile Arthritis
9. Biologics-naive juvenile idiopathic arthritis patients have elevated risk of cancer
10. Montreal researchers shed light on common juvenile cancer
11. Most states offer HPV vaccinations to girls in juvenile justice system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
For Juvenile Arthritis, Pill May Work as Well as Needle
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal ... Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Cut Pro X users can now reveal the media of their split screens ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... today announced its strategic partnership with Connance, a healthcare industry leader providing ... companies’ proven, proprietary technology combine to provide health systems, hospitals and ambulatory ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest ... . , Millions of individuals in the United States and Canada wear eyeglasses. Once ... to both correct vision and make a fashion statement. Even celebrities use glasses as ...
(Date:6/26/2016)... ... , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center ... Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This annual ... the world’s leading providers of cereal and other breakfast foods. Its residents often refer ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at www.diabetesscholars.org by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
Breaking Medicine Technology: