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For First Time, Pain 'Signature' Spotted on Brain MRIs
Date:4/10/2013

ave a mental illness. Both Wang and Wager said it would be helpful to have a way to complement patients' pain reports with an objective measure -- which in many cases might suggest that patients are in more pain than they are letting on, or in more pain than a doctor believes.

"We know that right now many people have their pain undertreated," Wager noted.

But scientists are a long way from using fMRI scans to gauge pain, according to Wang at NYU. "This is a comprehensive, meticulous study," he said, but added that it's also an early step.

One big caveat is that the study volunteers were all healthy and exposed to just one type of pain -- short-lived pain from heat applied to the skin. Wang said researchers need to see whether this same brain "signature" would appear in people with chronic pain conditions, or pain after surgery, for example.

And since fMRI scans are expensive, Wang noted, studies would have to show that the imaging actually benefits patients before it would be routinely used in the real world.

The study involved a total of 114 healthy young adults who took part in different phases of the research. First, Wager's team found that fMRI scans were able to pick up a reliable pain signature in the brain when volunteers had painful heat applied to their forearms.

The researchers then found that the signature was different and stronger than brain activity that popped up in response to the sensation of warmth, or to anticipation or remembrance of the pain.

More interesting, Wager said, was that the signature seemed to be unique to physical pain. In one set of experiments, the researchers had heartbroken volunteers who'd recently gone through a breakup look at a photo of their ex-partner. That did trigger activity in brain regions related to physical pain, but the signature linked to heat-induced pain remained distinct.

Wager agreed that much more work needs to be done, and his team is already looking at whether
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