Navigation Links
For Better Mouse Studies, Let Them Nest
Date:3/30/2012

FRIDAY, March 30 (HealthDay News) -- Cold conditions may affect the well-being of laboratory mice and influence the outcome of research studies, a new study suggests.

Researchers from the Stanford University School of Medicine found that nine of 10 drugs tested on mice that were housed in chilly temperatures failed to work in people. They suggested this may be because being cold triggers changes in mice's immune function and slows their growth.

"If you want to design a drug that will help a patient in the hospital, you cannot reasonably do that in animals that are cold-stressed and are compensating with an elevated metabolic rate," study author Joseph Garner, an associate professor of comparative medicine, said in a Stanford news release. "This will change all aspects of their physiology -- such as how fast the liver breaks down a drug -- which can't help but increase the chance that a drug will behave differently in mice and in humans."

The study authors argued that one simple way to correct this problem would be to allow laboratory mice to warm up, which would make them more physiologically comparable to people.

"Why not let them do what they do in the wild, which is build nests? Mice can happily infest a meat freezer, with temperatures far below zero, but they survive and breed because they build these wonderful nests," Garner said.

To test their theory, the researchers created sets of two cages linked by a small tube for 36 male and 36 female mice of three common strains. In each of the sets, one cage was kept at a cool 68 degrees Fahrenheit and was equipped with various amounts of shredded paper that the mice could use to make nests to keep warm and provide themselves with shelter. The connected cage had no nesting material and was kept at one of six temperatures, ranging from 68 to 95 degrees Fahrenheit.

The mice were allowed to choose which side of the cage they wanted to use. Although the strain and sex of the mice played a role in their preferences, the study revealed none of the mice chose to stay cold. Instead, whenever they had the option the mice chose to move to a warmer cage.

The mice also moved nesting material from colder cages to warmer cages, suggesting nests serve as more than a source of warmth for mice. The researchers noted that nests could also be a source of physical comfort or protection for mice that relieves their stress or anxiety.

The study authors added that nests also offer clues about how the mice are doing physically. "The shape of the nest tells an experienced person whether the animals are too hot or too cold, whether they are sick or whether they are about to give birth," Garner said. "Once you learn how to 'speak mouse nest,' the nest is a wonderful tool that anyone can use to assess the general state of the mouse."

The study, published online March 30 in the journal PLoS ONE, pointed out that simply raising the temperature in research laboratories wouldn't work because the mice would get too aggressive. The researchers concluded that laboratory mice should be routinely supplied with as much as 10 grams of nesting material.

More information

The U.S. National Cancer Institute provides more information on laboratory mice.

-- Mary Elizabeth Dallas

SOURCE: Stanford University School of Medicine, news release, March 30, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. People With Autism May Be Better at Processing Information
2. Kids Willing to Fail May Perform Better Academically
3. Closing hole in the heart no better than drugs in preventing strokes
4. Parent Training May Help Kids With Autism Behave Better
5. Study: Sleep gets better with age, not worse
6. New test can better predict successful IVF embryos, scientists say
7. Stents No Better Than Medicine for Stable Heart Disease, Study Says
8. More Kidney Dialysis Is Better, Research Finds
9. Specific Dietary Goals May Help Diabetics Eat Better
10. SBRT provides better outcomes than surgery for cancer patients with common lung disease
11. Chemists mimic nature to design better medical tests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
For Better Mouse Studies, Let Them Nest
(Date:5/31/2016)... ... 31, 2016 , ... More than 80 representatives of the Hepatitis B ... Cancer Foundation held an event on National Hepatitis Testing Day outside of Philadelphia City ... the leading cause of liver cancer. , Foundation leaders and the citywide coalition they ...
(Date:5/31/2016)... ... May 31, 2016 , ... ... mix of advanced Artificial Intelligence (AI) and the latest in Clinical Patient ... center is integrating predictive analytic outputs directly into the clinical workflow. These insights ...
(Date:5/31/2016)... ... May 31, 2016 , ... Effective leaders not only drive service to the ... whole. On June 2, Northbound CEO Mike Neatherton and COO Paul Alexander will be ... opening plenary on “Leadership: The Journey to Authenticity” with Onsite Workshops CEO Miles Adcock ...
(Date:5/31/2016)... ... 31, 2016 , ... In his latest video, renowned AstroNumerologist ... humans. Using presidential candidate Donald Trump as an example, Kalsi describes the way ... not about adding numbers up,” says Kalsi. “It is about looking at each ...
(Date:5/31/2016)... ... 31, 2016 , ... TeaZa® Energy, LLC announces the launch of ... No Tobacco Day . The new flavor—Tropical TeaZa? Energy—will be available to customers ... , The new flavor is best described as a juicy, taste bud takeover. ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... , May 26, 2016 According ... "Medical Waste Management Market - U.S. Industry Analysis, Size, Share, ... management market in the U.S. was valued at US$ 5.89 ... CAGR of 3.4% from 2015 to 2023 to reach US$ ... analysis of current and emerging needle free drug delivery devices ...
(Date:5/26/2016)... , May 26, 2016 ... With Both Cost Savings and Overall Decreased ... (LSE: BTG), an international specialist healthcare company, has ... the 21st Annual Meeting of ISPOR (International Society ... of hepatocellular carcinoma (HCC) using yttrium-90 glass microspheres ...
(Date:5/26/2016)... Since its commercial introduction in ... life science tool for conducting genetic studies in a ... in its new report that the industry sits on ... by a range of new applications in the clinical ... http://photos.prnewswire.com/prnh/20140723/694805 ) , Since the Human ...
Breaking Medicine Technology: