Navigation Links
Foot soldiers of the immune system
Date:1/13/2013

Researchers at McGill University and the Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences have discovered the molecular blueprint behind the IFIT protein. This key protein enables the human immune system to detect viruses and prevent infection by acting as foot soldiers guarding the body against infection. They recognize foreign viral ribonucleic acid (RNA) produced by the virus and act as defender molecules by potentially latching onto the genome of the virus and preventing it from making copies of itself, blocking infection. The findings are a promising step towards developing new drugs for combatting a wide range of immune system disorders.

The discovery was made by teams led by Bhushan Nagar, a professor in the Department of Biochemistry at McGill's Faculty of Medicine, and Dr. Giulio Superti-Furga at the CeMM. Building on the 2011 CeMM discovery by Dr. Andreas Pichlmair that IFIT proteins unexpectedly interact directly with the viral RNA to inhibit its replication, the group's latest discovery reveals the molecular mechanism behind how IFIT proteins capture only the viral RNA and distinguishes it from normal molecules belonging to the host. Their research will be published on January 13 in the journal Nature.

"Infection by pathogens such as viruses and bacteria are caught by a layer of the immune system that consists of guard-like proteins constantly on the lookout for foreign molecules derived from the pathogen," explains Prof. Nagar. "Once the pathogen is detected, a rapid response by the host cell is elicited, which includes the production of an array of defender molecules that work together to block and remove the infection. The IFIT proteins are key members of these defender molecules."

When a virus enters a cell, it can generate foreign molecules such as RNA with three phosphate groups (triphosphate) exposed at one end, in order to replicate itself. Triphosphorylated RNA is what dis
'/>"/>

Contact: Cynthia Lee
cynthia.lee@mcgill.ca
514-398-6754
McGill University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Report: Strategies to prevent noise-induced hearing loss, tinnitus in soldiers
2. War causes mental illness in soldiers
3. Explosions Are Main Cause of Spine Injuries in U.S. Soldiers
4. Energy Drinks Disrupting U.S. Soldiers Sleep: CDC
5. Todays U.S. Soldiers Fitter Than Decades Ago: Report
6. How does the immune system fight off threats to the brain? New research yields fresh insight
7. Regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis
8. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
9. Rutgers team discovers novel approach to stimulate immune cells
10. Scientists study serious immune malfunction
11. Babies susceptibility to colds linked to immune response at birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Reinberg HealthDay Reporter TUESDAY, ... reduce the need for blood transfusions might also protect the ... erythropoietin (EPO), which stimulates red blood cell production, appears to ... lead researcher Dr. Petra Huppi, a professor of pediatrics and ... "The real test of whether EPO protects the brains of ...
(Date:8/27/2014)... eat over 10 portions a week of tomatoes have ... cancer, new research suggests. , With 35,000 new cases ... prostate cancer is the second most common cancer in ... which some experts believe is linked to a Westernised ... and lifestyle recommendations reduces risk of prostate cancer, researchers ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 DISCcert has ... to take place Sept 10th, 17th, 24th, and Oct ... series will receive a certification seal that will allow ... The program consists of four weekly one-hour webinar sessions. ... complete, and are offered individual coaching time. , ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Global leaders ... policy will gather at the Minneapolis Marriott Northwest on ... worldwide explosion of robotics and autonomous systems at the ... In recognition of the wide variety of ways robotics ... & Expo created nine different tracks of content. For ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 Main Street Dental ... announcing its advice on how long a toothbrush can be ... best oral care for teeth and gums. , “Replacing a ... fairly regular basis," says Dr. Harvey Schwartz, owner of Main ... every three to four months." , Dr. Schwartz explains that ...
Breaking Medicine News(10 mins):Health News:Hormone Might Help Preemies' Brains 2Health News:Hormone Might Help Preemies' Brains 3Health News:Fighting prostate cancer with a tomato-rich diet 2Health News:Online DISC Certification Webinar Series to Begin Sept 10 Announces DISCcert 2Health News:Online DISC Certification Webinar Series to Begin Sept 10 Announces DISCcert 3Health News:Online DISC Certification Webinar Series to Begin Sept 10 Announces DISCcert 4Health News:Robotics Alley, LifeScience Alley Partner on Health Care & Medical Device Track 2Health News:Robotics Alley, LifeScience Alley Partner on Health Care & Medical Device Track 3Health News:Robotics Alley, LifeScience Alley Partner on Health Care & Medical Device Track 4Health News:Robotics Alley, LifeScience Alley Partner on Health Care & Medical Device Track 5Health News:Main Street Dental Team, Unionville’s Most Innovative Dental Clinic, Advises on the Best Time to Replace a Toothbrush 2
... Health and the University of Colorado Denver have discovered a ... acute lung injury. Acute lung injury (ALI) is often caused ... in the blood, and fluid in the lungs. It is ... afflicting almost 200,000 people in the United States each year, ...
... Pharos Innovations, a pioneer in,assisting clients to ... a device-free remote monitoring platform,today announced it is ... of two key appointments in medical informatics and ... http://www.newscom.com/cgi-bin/prnh/20080306/AQTH086LOGO ) , ...
... N.Y., Jan. 16 Bausch & Lomb, the ... Valenti, III, will join Bausch & Lomb as ... month."Pete possesses deep leadership experience, as well as ... Stuart Heap, corporate vice president and global president, ...
... 16 /PRNewswire-FirstCall/ - Thomas E. Gardner, Chairman, announced ... appointed to the NUCRYST Pharmaceuticals, Board of Directors. ... Executive Officer of The Westaim Corporation ("Westaim"), NUCRYST,s ... common shares. Prior to his appointment as President ...
... 16 /PRNewswire-Asia-FirstCall/ -- Mindray Medical,International Limited (NYSE: ... of medical devices worldwide, today announced updates on ... and international markets in,2009. , ... of ten products, achieving the goals,for new product ...
... in Guangdong ProvincePROVO, Utah, Jan. 15 Nu Skin ... that it has received official notification from the Chinese ... selling activities in four cities in the Guangdong province ... Skin Enterprises the opportunity to offer a direct selling ...
Cached Medicine News:Health News:Gene associated with reduced mortality from acute lung injury 2Health News:Pharos Innovations Strengthens Leadership Team, Informatics Program 2Health News:Pharos Innovations Strengthens Leadership Team, Informatics Program 3Health News:Bausch & Lomb Names Peter Valenti, III, as President, North America, Vision Care 2Health News:NUCRYST Pharmaceuticals appoints a new director 2Health News:NUCRYST Pharmaceuticals appoints a new director 3Health News:Mindray Medical Achieves 2008 Product Development Goals and Announces Strong Pipeline for 2009 2Health News:Mindray Medical Achieves 2008 Product Development Goals and Announces Strong Pipeline for 2009 3Health News:Mindray Medical Achieves 2008 Product Development Goals and Announces Strong Pipeline for 2009 4Health News:Mindray Medical Achieves 2008 Product Development Goals and Announces Strong Pipeline for 2009 5Health News:Nu Skin Enterprises Receives Broader Direct Selling Authorization in China 2
(Date:8/26/2014)... BLUE BELL, Pa. , Aug. 26, 2014 ... PRA Health Sciences, largest office worldwide. PRA, a leading global Contract ... and Fort Washington locations into ... . The new office opened this week and marks the ... an exciting time for us at PRA," said Harris Koffer ...
(Date:8/26/2014)... , Aug. 26, 2014 Biomedical Research ... has been named to the prestigious 2014 Inc. 500 ... honored to be included on this prestigious list and ... Chris Jacob , Biomedical Research Laboratories, CEO. "Today,s ... further serves to validate the hard work and talent ...
(Date:8/26/2014)... , Aug. 26, 2014 ... of the "Global Veterinary Diagnostics Market 2014-2018" ... Veterinary diagnostics include various tests, which are used ... livestock producers, and biomedical researchers are mainly availing ... testing (Deoxyribonucleic Acid/Ribonucleic Acid testing), immunodiagnostics, clinical chemistry, ...
Breaking Medicine Technology:PRA Health Sciences Expands in Pennsylvania 2Biomedical Research Laboratories Named to Inc. 500 List of America's Fastest-Growing Companies 2Global Veterinary Diagnostics Market 2014-2018: Key Vendors are Abaxis, Heska, IDEXX Laboratories, Mindray Medical, VCA Antech and Zoetis 2Global Veterinary Diagnostics Market 2014-2018: Key Vendors are Abaxis, Heska, IDEXX Laboratories, Mindray Medical, VCA Antech and Zoetis 3
... Graham-Field has been developing diverse ... 58 years. Our medical-surgical products ... for innovation, quality and customer ... include the Labtron® line of ...
Kit Nebulizer Small Volume Medication W/Pediatric Mask Mouthpiece 7FT O 2 Tubing...
... Small Volume Medication Mouthpiece 7FT O 2 ... advanced jet design for fast treatment times , ... a tighter distribution (higher percentage of respirable particles) ... AirLife™ brand Misty Max 10™ disposable nebulizers deliver ...
... Products, ,Westmed designs, manufacturers and markets ... Respiratory professionals. Our mission is to design ... ability to deliver quality medical care while ... , ,Our web site is designed ...
Medicine Products: