Navigation Links
Foot soldiers of the immune system
Date:1/13/2013

Researchers at McGill University and the Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences have discovered the molecular blueprint behind the IFIT protein. This key protein enables the human immune system to detect viruses and prevent infection by acting as foot soldiers guarding the body against infection. They recognize foreign viral ribonucleic acid (RNA) produced by the virus and act as defender molecules by potentially latching onto the genome of the virus and preventing it from making copies of itself, blocking infection. The findings are a promising step towards developing new drugs for combatting a wide range of immune system disorders.

The discovery was made by teams led by Bhushan Nagar, a professor in the Department of Biochemistry at McGill's Faculty of Medicine, and Dr. Giulio Superti-Furga at the CeMM. Building on the 2011 CeMM discovery by Dr. Andreas Pichlmair that IFIT proteins unexpectedly interact directly with the viral RNA to inhibit its replication, the group's latest discovery reveals the molecular mechanism behind how IFIT proteins capture only the viral RNA and distinguishes it from normal molecules belonging to the host. Their research will be published on January 13 in the journal Nature.

"Infection by pathogens such as viruses and bacteria are caught by a layer of the immune system that consists of guard-like proteins constantly on the lookout for foreign molecules derived from the pathogen," explains Prof. Nagar. "Once the pathogen is detected, a rapid response by the host cell is elicited, which includes the production of an array of defender molecules that work together to block and remove the infection. The IFIT proteins are key members of these defender molecules."

When a virus enters a cell, it can generate foreign molecules such as RNA with three phosphate groups (triphosphate) exposed at one end, in order to replicate itself. Triphosphorylated RNA is what dis
'/>"/>

Contact: Cynthia Lee
cynthia.lee@mcgill.ca
514-398-6754
McGill University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Report: Strategies to prevent noise-induced hearing loss, tinnitus in soldiers
2. War causes mental illness in soldiers
3. Explosions Are Main Cause of Spine Injuries in U.S. Soldiers
4. Energy Drinks Disrupting U.S. Soldiers Sleep: CDC
5. Todays U.S. Soldiers Fitter Than Decades Ago: Report
6. How does the immune system fight off threats to the brain? New research yields fresh insight
7. Regulatory immune cell diversity tempers autoimmunity in rheumatoid arthritis
8. Mayo Clinic: Exhaustion renders immune cells less effective in cancer treatment
9. Rutgers team discovers novel approach to stimulate immune cells
10. Scientists study serious immune malfunction
11. Babies susceptibility to colds linked to immune response at birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... January 22, 2015 Juvent Sports ( ... the 2015 PGA Merchandise Show to bestow a Juvent ... female amateur golfer, Arlene McKitrick. The award commemorated and ... golf tournament win. She won her first amateur tournament ...
(Date:1/22/2015)... 20 years, Dr. David Cruz of Cruz Chiropractic Care ... about every type of injury that can result from car accidents ... years, the team at Doctors on Liens has been ... With the combined breadth of experience between the two, ...
(Date:1/22/2015)... January 22, 2015 Yesterday, Senator ... (D-Concord) and Kristin Olsen (R-Modesto) were honored by ... in advancing biotechnology, biomedical science, medical device and ... each received the “2014 Life Sciences Champion” award ...
(Date:1/22/2015)... 22, 2015 Payday lending practices in ... and cause financial distress to the states that permit ... Howard University’s Center on Race and Wealth. , While ... activity, payday loans at the same time substantially depress ...
(Date:1/22/2015)... Compare-autoinsurance.org has released a new blog post presenting a ... insurance policy . , Some types of vehicles cannot be ... newly released blog post to see if their vehicle qualifies for ... are some of the cars that cannot be covered by a ...
Breaking Medicine News(10 mins):Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2
... any moment may be keyed to what they expect to ... -- People like to temper their emotions to the task ... the emotions are not pleasurable ones, a new report suggests. ... for example, when they expect to complete a confrontational task ...
... ,hands on, approach and strategic ... statement, BOSTON, April 4, 2008 The Board ... of Robert Hernreich to the,organization,s board of directors. Mr. ... officially took his place on the board in,late 2007., ...
... Put Medical Equipment Providers Out of Business and,Disrupt Services ... Disabled People,in Ohio, ARLINGTON, Va., April 4, 2008 ... (DME) scheduled to be,implemented in the Cincinnati and Cleveland, ... providers out of business and will likely disrupt,services for ...
... has been reported that highlights the problems that oxidative ... can generate in relation with the pathogenesis of Alzheimer,s ... throughout the world. The results of research carried out ... from the laboratory of Professor Dr. R.B. Maccioni of ...
... than 26,000 rushing in for acute care each year, study ... well is graceful and awe-inspiring, but one misstep or misplaced ... American children end up in hospital emergency rooms due to ... the April issue of Pediatrics . , "Gymnastics has ...
... Joint Commission Campaign Urges Patients to Take an ... Ill., April 4, 2008 ,Understanding the often complex ... you can be difficult, and the consequences of,misunderstanding ... Joint Commission is launching a national campaign to ...
Cached Medicine News:Health News:Study Shows Anger Has Its Uses 2Health News:Global Action Board of Directors Announces Addition of Newest Member, Robert Hernreich 2Health News:Errors Plague Medicare 'Competitive Bidding' Program in Ohio, Says American Association for Homecare 2Health News:Errors Plague Medicare 'Competitive Bidding' Program in Ohio, Says American Association for Homecare 3Health News:Errors Plague Medicare 'Competitive Bidding' Program in Ohio, Says American Association for Homecare 4Health News:Redox-active iron is a sensor of cognitive impairment associated with Alzheimer's disease 2Health News:Young Gymnasts Tumbling and Vaulting Their Way to the ER 2Health News:Young Gymnasts Tumbling and Vaulting Their Way to the ER 3Health News:'Understanding Your Caregivers' Promotes Health Literacy 2Health News:'Understanding Your Caregivers' Promotes Health Literacy 3
(Date:1/23/2015)... 23, 2015 More than a third of reproductive-aged women ... with private insurance, filled a prescription for an opioid pain ... this week,s Morbidity and Mortality Weekly Report (MMWR). ... treat moderate to severe pain.  They are also found in ...
(Date:1/23/2015)... , Jan. 23, 2015  Now available for sale, ... 7,849,611) support that prevents ankle sprains by cushioning the ... it fits securely around the outside of any shoe ... & comfort while still offering protection against sprains. With ...
(Date:1/23/2015)... , Jan. 23, 2015  CytoSorbents Corporation (NASDAQ ... its CytoSorb® extracorporeal cytokine adsorber to reduce deadly ... the receipt of $385,642, net of transaction costs, ... the Technology Business Tax Certificate Transfer Program sponsored ...
Breaking Medicine Technology:Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3
... body temperatures of newborns with temporal artery thermometry (forehead ... (under arm) thermometry, the clinically recommended method for this ... new study reported in Advances in Neonatal Care ... clinical analysis evaluating the accuracy of temporal artery thermometry ...
... BB&T Capital Markets served as the exclusive financial advisor ... developer, manufacturer and marketer of therapeutic footwear and related ... Global, an international provider of medical device solutions for ... Vista, Calif. Dr. Comfort generated net sales of $71.8 ...
Cached Medicine Technology:Study Finds Exergen Temporal Artery Thermometry Accurate on Newborns 2Study Finds Exergen Temporal Artery Thermometry Accurate on Newborns 3BB&T Advises Dr. Comfort on Its Sale to DJO Global in Transaction Valued at $254.6 Million 2
Scoville Ruptured Disc Curettes, length 10" (254 mm), cup size 4 x 10 mm....
PG Magnum Ring Curettes, total length 12.6" (32 cm), handle length 7.8" (20 cm), handle diameter 1.12" (3 cm), working distance 4.7" (12 cm), dual-coned, precision sharpened rings....
XL Cervical Curette comes with a bayonet design and satin black handles having instrument length 9.5" (24 cm), working distance4.1" (10.4 cm) and handle width 0.6" (1.5 cm)....
Bone Curette, 160 mm...
Medicine Products: