Navigation Links
Food restriction increases dopamine receptor levels in obese rats

UPTON, NY -- A brain-imaging study of genetically obese rats conducted at the U.S. Department of Energy's Brookhaven National Laboratory provides more evidence that dopamine - a brain chemical associated with reward, pleasure, movement, and motivation - plays a role in obesity. The scientists found that genetically obese rats had lower levels of dopamine D2 receptors than lean rats. They also demonstrated that restricting food intake can increase the number of D2 receptors, partially attenuating a normal decline associated with aging.

"This research corroborates brain-imaging studies conducted at Brookhaven that found decreased levels of dopamine D2 receptors in obese people compared with normal-weight people," said Brookhaven neuroscientist Panayotis (Peter) Thanos, lead author of the current study, which will be published in the journal Synapse and is now available online.

It's not clear whether reduced receptor levels are a cause or consequence of obesity: Overeating may chronically reduce receptor levels, which, over the long term, could eventually contribute to obesity. But having genetically low receptor levels may also lead to obesity by predisposing the individual to overeating in an attempt to stimulate a "blunted" reward system. Either way, revving up receptor levels by restricting food intake could enhance the impact of this common strategy for combating obesity.

"Consuming fewer calories is obviously important for people trying to lose weight, plus improving the brain's ability to respond to rewards other than food may help prevent overeating," Thanos said. Because food intake can have such a dramatic effect on dopamine receptor levels, "this study also provides further evidence for the interplay of genetic factors with the environment in the development of obesity in our society," he said.

The finding that food restriction can attenuate the effects of aging on the brain's ability to respond to dopamine may also help explain why food restriction slows down other changes associated with aging, such as declines in locomotor activity and sensitivity to reward.

Study methods and main findings

The researchers measured dopamine D2 receptor levels in adolescent and young adult genetically obese Zucker rats and lean rats. Between measures, half of the rats in each group were given free access to food while the other half were given 70 percent of the daily average amount of food eaten by the unrestricted group.

The scientists measured D2 receptor levels using two different techniques: micro-positron emission tomography (microPET) in living animals, which uses a radioactively tagged molecule that competes with the brain's natural dopamine for D2 receptor binding sites, and autoradiography, which uses a tracer that binds more strongly than natural dopamine but can only be used in tissue samples rather than in living animals. Together these two methods indicate the absolute number of D2 receptors found in the brain and how many are available or free during day-to-day function, which might be relevant to further elucidating the role of dopamine in obesity.

One main finding was that the overall number of D2 receptors was lower in obese than in lean rats. Also D2 receptor levels decreased with age, but this decline was significantly blunted in food-restricted rats compared with those given free access to food. This attenuation was most apparent in the obese rats.

Another main finding was that D2 receptor availability - that is, the number of receptors available for binding dopamine - was greater at adulthood in the obese rats compared to the lean rats. This suggests that perhaps the release of dopamine had significantly decreased with age in the obese unrestricted animals more than in the restricted ones or the lean rats. The possibility of lower release of dopamine in obese subjects is presently being examined, the researchers say.


Contact: Karen McNulty Walsh
DOE/Brookhaven National Laboratory

Related medicine news :

1. FDA Imposes New Restrictions On Roches Accutane
2. Drink till you drop dead in English Pubs- Restriction on Timings Lifted
3. Liberated British Mothers Want No Restriction on Breast Feeding In Public
4. Bird Flu Restrictions To Be Lifted In Scotland
5. Restriction of Carbohydrates to Prevent Alzheimers Disease
6. No More Dietary Restriction for Heartburn Patients - Study Says
7. Restrictions Imposed on Sale of Edible Common Salt
8. Bush Supports Restriction to ‘Morning–After’ Pll
9. Netherlands to lift livestock restrictions over avian influenza
10. Air travel restriction could hinder flu
11. Calorie Restriction May Prevent, Reduce Alzheimer’s Neuropatholog
Post Your Comments:
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June ... , brings up a new, often overlooked aspect of head lice: the parasite’s ability to ... is not a common occurrence, but a necessary one in the event that lice have ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... ... athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as ... City area —Johnson is one of the first doctors to perform the treatment. ...
(Date:6/24/2016)... ... , ... Those who have experienced traumatic events may suffer from a complex ... as drug or alcohol abuse, as a coping mechanism. To avoid this pain and ... a traumatic event. , Trauma sufferers tend to feel a range of emotions, from ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Key Pharma News Issue 52" report to their offering. ... need in influenza treatment creates a favourable commercial environment for ... and growing patient base that will serve to drive considerable ... flu vaccine would serve to cap sales considerably, but development ...
Breaking Medicine Technology: