Navigation Links
Food peptides activate bitter taste receptors

PHILADELPHIA (January 22, 2008) -- Researchers from the Monell Center and Tokyo University of Agriculture have used a novel molecular method to identify chemical compounds from common foods that activate human bitter taste receptors.

The findings, published in the journal Biochemical and Biophysical Research Communications, provide a practical means to manipulate food flavor in general and bitter taste in particular.

Identification of bitter taste compounds and their corresponding receptors opens doors to screening for specific bitter receptor inhibitors, said senior author Liquan Huang, PhD, a molecular biologist at Monell. Such inhibitors can be used to suppress unpleasantness and thereby increase palatability and acceptance of health-promoting bitter foods, such as green vegetables or soy products.

While a little bitterness is often considered a desirable component of a foods flavor, extensive bitterness can limit food acceptance.

About 25 different human bitter receptors have been identified from human genome sequences. However, only a few of these bitter receptors can be activated by known chemical compounds. The remainders are orphan receptors, meaning that the compounds that bind to and activate them have not been identified. Consequently, it is unclear how these orphan receptors contribute to bitter taste perception.

Huang and his collaborators deorphanized several bitter receptors by demonstrating that peptides from fermented foods can specifically stimulate human bitter taste receptors expressed in a cell culture system.

Fermented foods, such as cheese or miso, are characterized by bitter off-tastes. These foods also contain abundant quantities of peptides, which are short chains of amino acids, the building blocks of proteins.

The results reveal the molecular identities of chemical food components responsible for the bitterness of fermented foods and demonstrate that bitter-tasting peptides are detected by human bitter receptors in an analogous manner to other bitter compounds.

Information on how food constituents interact with receptors is needed to design and identify inhibitors and enhancers that can be targeted towards specific bitter compounds, says Huang. Our findings may help make health-promoting bitter foods such as broccoli more palatable for children and adults.


Contact: Leslie Stein
Monell Chemical Senses Center

Related medicine news :

1. Potent peptides inhibit HIV entry into cells
2. Smokers Brain Centers Activate During Nicotine Cravings
3. Belief, disbelief and uncertainty activate distinct brain regions
4. YMCAs Activate America(R) Motivates More Than 1.3 Million People to Take 8 Billion Steps Toward a Healthier Lifestyle During America On the Move Week with the YMCA
5. Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During America on the Move Week With the YMCA, September 22-29, 2007
6. FLAVORx Teams up with Wedgewood Pharmacy to Make it Even Easier to Make Pet Medications Taste Good
7. Almost Half of 10-Year-Olds Have Tasted Alcohol
8. Smoking Dulls Taste for Sweets
9. Sense of taste different in women with anorexia nervosa
10. New Herbal Water Creating Taste Sensation: Ayalas Herbal Water Has No Calories, No Preservatives and No Artificial Additives. Just All the Natural Benefits of Herbs!
11. Top Tips to Enjoy Healthy Latin Food Without Losing the Taste (Recipe)
Post Your Comments:
(Date:11/27/2015)... Chicago, IL (PRWEB) , ... November 27, 2015 ... ... some of the largest, most successful and prominent nonprofit healthcare organizations in the ... and governance involvement with various organizations, and helped advance the healthcare industry as ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... Avid collector, ... Ann Arbor Michigan boxing style concert posters. This is one of Joplin's most famous ... Canterbury House at the University of Michigan in Ann Arbor. The According to Hawley, ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... located in central Michigan, have come together on Thanksgiving Day to share the ... available for viewing on the Serenity Point YouTube channel, patients displayed what they ...
(Date:11/26/2015)... ... November 26, 2015 , ... CognisantMD ... for diagnostic imaging in the Waterloo region. Using the Ocean Platform, family physicians ... directly from their electronic medical record (EMR) without the need for redundant patient ...
(Date:11/26/2015)... ... November 26, 2015 , ... The Catalent Applied Drug ... need to integrate dose form selection in early phase drug development. The first ... supporting and bringing together the UK’s emerging life sciences companies, corporate partners, and ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... 2015 Research and Markets ( ) ... Devices Market 2015-2019" report to their offering. ... this report, the author the present scenario and growth ... To calculate the market size, the report considers revenue ... Hormonal IUDs and copper IUDs. The report forecasts the ...
(Date:11/26/2015)... November 27, 2015 ... --> Medical alert ... system (PERS) market is expected ... years with APAC being the ... see a high CAGR between ...
(Date:11/26/2015)... North Carolina , 26 november 2015 ... Inc. (AAIPharma/CML) kondigt de geplande investering aan ... uitbreiding van de laboratoria en het mondiale ... . De uitbreiding zal resulteren in extra ... wordt voldaan aan de groeiende behoeften van ...
Breaking Medicine Technology: