Food Phosphates Might Spur Lung Cancer( Accelerated growth of tumors seen in ...),Health

Accelerated growth of tumors seen in mouse study

MONDAY, Dec. 29 (HealthDay News) -- A diet rich in the inorganic phosphates found in many natural and processed foods accelerated the growth of lung cancers in rats, South Korean researchers report.

"Our study suggests that dietary regulation of inorganic phosphates may be critical for lung cancer treatment as well as prevention," Myung-Haing Cho, lead author of a report in the first January issue of American Journal of Respiratory and Critical Care Medicine, said in a statement.

But, "an individual shouldn't act on these results as yet, other than to encourage funding organizations such as the National Institutes of Health to support research to see whether dietary phosphates encourage cancer," said Dr. John Heffner, a professor of medicine at the Oregon Health & Science University in Portland and past president of the American Thoracic Society, which publishes the journal.

Natural sources of dietary phosphates include leafy vegetables, fruits, meats and poultry products. Phosphates also are added to a number of foods, including baking powder, carbonated cola drinks, ice cream, bread, rolls, macaroni, fruit jellies and preserves. Food phosphates are listed by the U.S. Food and Drug Administration as GRAS -- generally recognized as safe -- with no limits on their use.

The South Korean study was done with two breeds of laboratory mice, one genetically inclined to have lung cancer, the other with induced lung cancers. They were fed either diets containing phosphates in roughly the same amounts found in human diets or phosphates at twice that level. After four weeks, more and larger lung cancers were found in the rats given the higher-phosphate diets, the report said.

Phosphates appear to activate a metabolic pathway that stimulates the growth of the lung tumors, the researchers said.

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