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Following the traces of lung cancer
Date:6/10/2011

research was carried out on 48 patients at the Cruces Hospital in Barakaldo (in the Basque province of Bizkaia and near Bilbao), who were injected with a dose of 0.25 millicuries within the tumour, divided into its four quadrants. After ten minutes, the radiation of the tumour and the intrathoracic ganglionary stages were measured with a manual gamma radiation counter. Migration of the radioisotope was deemed satisfactory when the radiation was thrice that marked in the primary tumour. Then, the usual operation was carried out, including tumour extraction, ganglionary sampling and recommended grade of extirpation of ganglia, depending on the case. Subsequently, gamma measurement was undertaken on these samples outside the organism. Sentinel nodes are considered to be those which, once again, showed radiation was thrice that of the base value, as this radioactivity shows the path traced by the substance and, it is thus deduced, by the disease.

Positive results of over 90 %

The results show that identification of the lung sentinel node is possible with the use of radioisotopes in an intraoperative manner. Sentinel nodes were identified in 100 % of cases, while the sensitivity, precision and negative predictive value of the technique gave values close to or greater than 90 %. There was a rate of negative false values of 11.76 %; i.e. there were cases in which radioactivity was not detected in a zone in which there was, in fact, a sentinel node. It should also be pointed out that sentinel nodes and lymphatic nodes with greatest risk of metastasis are those located near the tumour. Moreover, there may be cases in which there is more than one sentinel node (in two of the 48 cases, two were found).

Ms Uribe-Etxebarria concludes that the technique studied enhances the ganglionary staging of the patients with resectable non-small cell lung cancers (NSCLC). Detecting the sentinel node provides clues to the affected zone. This enables the path
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Contact: Amaia Portugal
a.portugal@elhuyar.com
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Elhuyar Fundazioa
Source:Eurekalert

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