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Following direction: How neurons can tell top from bottom and front from back
Date:6/19/2014

TORONTO The question of how neurons and their axons establish spatial polarity and direction in tissues and organs is a fundamental question of any organism or biological system. Our cells and axons precisely orient themselves in response to external cues, but what are the core pathways and how are they integrated?

Lead author Dr. Naomi Levy-Strumpf and principal investigator Dr. Joseph Culotti developed a novel conceptual framework, published on-line in PLoS GENETICS, June 5 2014.

They investigated netrin and Wnt, signaling pathways that are implicated in cancer as well as in normal development. Working with C. elegans, they found that the UNC-6/netrin guidance cue, which has a conserved role in guiding cell and growth-cone migrations along the dorso-ventral axis, contributes to establishing antero-posterior polarity. Meanwhile, Wnts that are critical for determining polarity and guidance along the A/P axis are also involved in setting up polarity along the D/V axis. This provides a novel conceptual view of how A/P and D/V guidance signals are integrated intracellularly to generate polarized migration.

Redundancy goes both ways

An unexpected finding is that each pathway is redundant in both in A/P and D/V guidance, and in diverse processes that are involved in viability. "This redundancy tends to mask the roles of netrin and Wnt signaling in various biological processes," says Dr. Levy-Strumpf. "Now that we have identified the redundancy we can get a better insight into the concerted contribution of these two key signalling pathways in normal development as well as in tumor progression and metastasis." She is a research associate in the Culotti lab. Dr. Culotti is a Senior Investigator at the Lunenfeld-Tanenbaum and is a Professor of Molecular Genetics at University of Toronto.

'By means of a comprehensive genetic analysis, we found that simultaneous loss of Wnt and netrin sign
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Contact: Polly Thompson
pthompson@lunenfeld.ca
41-658-648-002-046
Lunenfeld-Tanenbaum Research Institute
Source:Eurekalert

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