Navigation Links
Following colorectal cancer surgery, longer delay before chemotherapy associated with worse survival
Date:6/4/2011

An analysis of data from previously published studies indicates that longer time to beginning adjuvant chemotherapy after surgery for colorectal cancer is associated with worse survival, according to a study in the June 8 issue of JAMA, a theme issue on cancer. The study is being published early online to coincide with its presentation at the American Society of Clinical Oncology 2011 Annual Meeting.

"Colorectal cancer (CRC) is the third leading cause of cancer mortality in the Western world. While surgical resection [removal] remains the cornerstone of management for patients with stage I-III disease, a considerable proportion of patients will ultimately relapse and die from their disease," according to background information in the article. "Adjuvant chemotherapy [AC; chemotherapy after surgery] improves survival among patients with resected colorectal cancer. However, the optimal timing from surgery to initiation of AC is unknown." There is also a question of the benefit of beginning chemotherapy after a certain time period, typically believed to be 12 weeks.

James J. Biagi, M.D., of Queen's University, Kingston, Ontario, Canada, and colleagues conducted a review and meta-analysis of studies that assessed the relationship between time to AC and survival in CRC. Studies were only included if relevant prognostic factors were adequately described and either comparative groups were balanced or results adjusted for these prognostic factors. The researchers identified 10 eligible studies involving 15,410 patients (7 published articles, 3 abstracts) that met study criteria for inclusion. Nine of the studies were cohort or population based and 1 was a secondary analysis from a randomized trial of chemotherapy.

The researchers found that meta-analysis indicated that a 4-week increase in time to AC was associated with a significant decrease (14 percent) in both overall survival and disease-free survival. There was no significant hete
'/>"/>

Contact: Christina Archibald
christina.archibald@queensu.ca
613-533-2877
JAMA and Archives Journals
Source:Eurekalert

Page: 1 2

Related medicine news :

1. PolicyLink CEO Angela Glover Blackwell Released the Following Statement on First Lady Michelle Obamas Childhood Obesity Initiative
2. Connecticut Board Considers Warning About Risk Of Stroke Following Chiropractic Neck Manipulation
3. Study supports alternative anti-seizure medication following acute brain injury
4. International Medical Corps on the Ground in Chile, Following 8.8-Magnitude Earthquake
5. Long Term Care Insurance Leader Seeks 320 New Agents in 2010, Following Strong 2009 Growth
6. Poor More Likely to Die Following Heart Surgery
7. New Study Identifies Cause of Severe Disequilibrium and Significant Memory Loss Following Stapedectomy Surgery
8. ShelterBox Aid en route to Mexico Following Earthquake
9. Patient-physician compatibility increases odds of following doctors orders
10. Lottery game helps to assess brain damage following stroke
11. Falls and follow-ups: Medical attention following a fall critical to senior health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... (GSA) and the National Center for Creative Aging ... University as the 2014 recipient of the Gene D. ... award recognizes and honors the seminal work of Gene ... and aging shifted the conceptual focus from a problem ... individuals to approach longevity asking what wonders can be ...
(Date:7/29/2014)... boys with fragile X syndrome tend to decline ... of the inherited disorder to date has found. ... social and practical skills, including communication, socialization, and ... dressed. In this study, socialization emerged as a ... that it did not decline as much as ...
(Date:7/29/2014)... More Zeppelin than Zen, the Rock Spa® at Seminole Hard ... complete renovation and, upon its re-opening in the fall, will ... , The Rock Spa® will include an all-new hair and ... hair and nail stylists. Both part time and full time ... given full medical and health benefits, a rare perk in ...
(Date:7/29/2014)... Society of America (GSA) the nation,s largest ... has chosen Laura N. Gitlin, PhD, of the Johns ... 2014 recipient of the M. Powell Lawton Award. ... gerontology that has led to an innovation in gerontological ... barriers, or a public policy change that has led ...
(Date:7/29/2014)... truBrain has created a solution for ... drinks. Think Drinks , available today on Indiegogo, ... conditions for memory, complex reasoning and sustained energy while ... $50,000 over the course of the 30-day campaign. , ... have compounding effects over time when used as a ...
Breaking Medicine News(10 mins):Health News:Charon to receive 2014 Gene D. Cohen Award 2Health News:Socialization relative strength in fragile X longitudinal study 2Health News:Rock Spa® at Seminole Hard Rock Hotel & Casino Tampa Prepares for Expansion 2Health News:Gitlin earns GSA's 2014 M. Powell Lawton Award 2Health News:Focus- and Productivity-Enhancing Beverage Launches Crowdfunding Campaign on Indiegogo 2
... The American College of Radiology (ACR) and Society of ... Obstetricians and Gynecologists, (ACOG) recommendations that women begin getting ... now correspond with those of the American Cancer Society, ... Breast Disease (ASBD) and many other major medical associations ...
... HealthDay Reporter , WEDNESDAY, July 20 (HealthDay News) -- ... disease as a major health threat, fearing its onset nearly ... Germany, Poland, Spain and the United States, the poll also ... to visit a doctor if they or a loved one ...
... HealthDay Reporter , WEDNESDAY, July 20 (HealthDay News) ... players can quantify the force of impact, offering new insight ... collisions may eventually help manufacturers design helmets that are more ... the University of Michigan and lead author of a new ...
... (HealthDay News) -- Premature infants are at greater risk ... hyperactivity and depression, a new study suggests. These ... affecting cortical development as well as neural connectivity, said ... Although "preemies" are at risk for these injuries, the ...
... gene-based test to distinguish harmless from precancerous pancreatic cysts. ... needless surgery to remove the harmless variety. A ... 20 issue of Science Translational Medicine . ... more than a million patients each year, most of ...
... a special fascination for Marlene Zuk , world-class evolutionary ... offer us, she says, a way to understand living things ... "People have strong feelings about insects, and most of those ... at the University of California, Riverside. "But insects let ...
Cached Medicine News:Health News:ACR, SBI support updated ACOG recommendations that women begin annual mammograms at age 40 2Health News:International Poll Shows Many Fear Alzheimer's as Much as Cancer 2Health News:International Poll Shows Many Fear Alzheimer's as Much as Cancer 3Health News:High-Tech Football Helmets Gauge Force of Collision 2Health News:Preemies at Risk for Psychiatric Disorders as Teens, Study Contends 2Health News:Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts 2Health News:Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts 3Health News:'Sex on Six Legs' is focus of UC Riverside biologist's book 2Health News:'Sex on Six Legs' is focus of UC Riverside biologist's book 3Health News:'Sex on Six Legs' is focus of UC Riverside biologist's book 4
(Date:7/29/2014)... COLORADO SPRINGS, Colo. , July 29, 2014 /PRNewswire-USNewswire/ ... remote-controlled catheter (MARC) which could allow physicians to see ... stroke may hold promise, according to study authors who ... Surgery (SNIS) 11 th Annual Meeting in ... findings stand to advance the field of neurointervention, a ...
(Date:7/29/2014)... NASHVILLE, Tenn. and NEW YORK ... and member of the executive management team of Caremark ... of PBM365 Media ( www.pbm365.com ).  PBM365 is the ... and unbiased reporting, insight, analysis and opinion on ... PBM365 will provide insightful and timely coverage of, ...
(Date:7/29/2014)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) launched its presence ... Clinical Lab Expo today by unveiling two booths (#1209 ... partnering with customers to redefine the value of the ... that they,re looking for a partner to help them ... offices," said Jack Phillips , president and CEO ...
Breaking Medicine Technology:New Technology May Improve Visualization Of The Brain During Stroke Treatment 2New Technology May Improve Visualization Of The Brain During Stroke Treatment 3Drew Crawford Announces Launch of PBM365 Media 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 2Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 3Roche focuses on partnering with customers to redefine the value of the laboratory at the AACC 2014 Clinical Lab Expo 4
... Inc . announced today that David A. Weber, Ph.D. , ... Board of Directors. Jay Lichter, Ph.D., managing director of Avalon Ventures, ... actively support the company as a member of the Board of ... to the Otonomy team, as his extensive experience in the development ...
... 2010 Amicus Therapeutics (Nasdaq: FOLD ), ... diseases, today announced that it has been awarded a ... Parkinson,s Research (MJFF) for the development of a novel, ...  The $500,000 award will be distributed over a period ...
Cached Medicine Technology:Otonomy Appoints David A. Weber, Ph.D., Chief Executive Officer 2Otonomy Appoints David A. Weber, Ph.D., Chief Executive Officer 3Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease 2Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease 3Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease 4Amicus Therapeutics Awarded $500,000 Grant from The Michael J. Fox Foundation for Development of Next-Generation Pharmacological Chaperone to Treat Parkinson's Disease 5
Colloidal Gold Conjugated, Protein A - 12 OD...
Polyester ribbons (3) impregnated with different OD values of conjugated Protein G...
Colloidal Gold Conjugated, Protein G - 12 OD...
Colloidal Gold Sol, 40 nm - 50 OD, 1 ml, Gold Sol Nanoparticles - not boiled, not centrifuged...
Medicine Products: