Navigation Links
Following colorectal cancer surgery, longer delay before chemotherapy associated with worse survival
Date:6/4/2011

An analysis of data from previously published studies indicates that longer time to beginning adjuvant chemotherapy after surgery for colorectal cancer is associated with worse survival, according to a study in the June 8 issue of JAMA, a theme issue on cancer. The study is being published early online to coincide with its presentation at the American Society of Clinical Oncology 2011 Annual Meeting.

"Colorectal cancer (CRC) is the third leading cause of cancer mortality in the Western world. While surgical resection [removal] remains the cornerstone of management for patients with stage I-III disease, a considerable proportion of patients will ultimately relapse and die from their disease," according to background information in the article. "Adjuvant chemotherapy [AC; chemotherapy after surgery] improves survival among patients with resected colorectal cancer. However, the optimal timing from surgery to initiation of AC is unknown." There is also a question of the benefit of beginning chemotherapy after a certain time period, typically believed to be 12 weeks.

James J. Biagi, M.D., of Queen's University, Kingston, Ontario, Canada, and colleagues conducted a review and meta-analysis of studies that assessed the relationship between time to AC and survival in CRC. Studies were only included if relevant prognostic factors were adequately described and either comparative groups were balanced or results adjusted for these prognostic factors. The researchers identified 10 eligible studies involving 15,410 patients (7 published articles, 3 abstracts) that met study criteria for inclusion. Nine of the studies were cohort or population based and 1 was a secondary analysis from a randomized trial of chemotherapy.

The researchers found that meta-analysis indicated that a 4-week increase in time to AC was associated with a significant decrease (14 percent) in both overall survival and disease-free survival. There was no significant hete
'/>"/>

Contact: Christina Archibald
christina.archibald@queensu.ca
613-533-2877
JAMA and Archives Journals
Source:Eurekalert

Page: 1 2

Related medicine news :

1. PolicyLink CEO Angela Glover Blackwell Released the Following Statement on First Lady Michelle Obamas Childhood Obesity Initiative
2. Connecticut Board Considers Warning About Risk Of Stroke Following Chiropractic Neck Manipulation
3. Study supports alternative anti-seizure medication following acute brain injury
4. International Medical Corps on the Ground in Chile, Following 8.8-Magnitude Earthquake
5. Long Term Care Insurance Leader Seeks 320 New Agents in 2010, Following Strong 2009 Growth
6. Poor More Likely to Die Following Heart Surgery
7. New Study Identifies Cause of Severe Disequilibrium and Significant Memory Loss Following Stapedectomy Surgery
8. ShelterBox Aid en route to Mexico Following Earthquake
9. Patient-physician compatibility increases odds of following doctors orders
10. Lottery game helps to assess brain damage following stroke
11. Falls and follow-ups: Medical attention following a fall critical to senior health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... August 03, 2015 , ... Social impact ... AUGUST 3, 2015 – Since winning a South by Southwest® (SXSW®) Interactive Innovation ... an organization whose mission is to develop technology for the sake of humanity ...
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... announce the development of it’s new program “Designing Secure Healthcare Systems” This ... engineers and technology leaders from healthcare organizations with access to the tactics, techniques ...
(Date:8/3/2015)... ... August 03, 2015 , ... From ... by 39 percent, according to market research compiled for the National Association of ... U.S. Department of Labor, Bureau of Labor Statistics. As the number of dental ...
(Date:8/3/2015)... ... August 03, 2015 , ... Cambia Health ... overall performance of the company’s Medicare and Federal Employee Programs (FEP) lines of ... deliver better health for members. In this role, Scott is responsible for overseeing ...
(Date:8/3/2015)... ... August 03, 2015 , ... Recent reports by the American Medical ... least once in their lives. Often time, low back and sciatic pain can happen ... only be managed clinically with powerful pain medication or spinal surgery. Dynamic Health ...
Breaking Medicine News(10 mins):Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 2Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 3Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 4Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 2Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 3Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 4Health News:Dental Association Announces Impending Reduction of Dental Laboratories Could Impact Dentists 2Health News:Dental Association Announces Impending Reduction of Dental Laboratories Could Impact Dentists 3Health News:Cambia Health Solutions Names Scott Powers President of Government Programs 2Health News:Dynamic Health Care in Louisville, KY, Offers a New and Cutting-Edge Therapy for Low Back & Leg Pain Sufferers 2
... opening in September 2009 - ,Those studying in Edinburgh will be able ... provider UNITE opens a brand new development overlooking the Meadows this September ... ... for the new property in Chalmers Street has been opened to give ...
... (MCA) recently honored twelve (12) doctors for their endless dedication to ... those among them who have consistently supported the profession through their ... , ... Dr. Douglas Edwards, Albert Lea, MN , ...
... Breakthrough caregiver training to revolutionize senior home care ... Assistance of Palo Alto, California released its new ... Method(TM). This system, exclusive to Home Care Assistance ... North America with an emphasis on lifestyle, healthy ...
... - Bioniche Life Sciences Inc. ("Bioniche"; TSX: BNC), ... an update on its Phase III clinical program ... On March 31st, the Company announced that recruitment ... registration trial evaluating Urocidin in the treatment of ...
... intrinsic goals is what leads to well-being , , FRIDAY, May ... and fame may sound like a sure ticket to happiness, ... University of Rochester in New York tracked 147 college graduates, ... time -- one year after graduation, and then 12 months ...
... 22 Researchers at Roswell Park Cancer Institute (RPCI) in ... the need to vaccinate both young men and women against ... comes amid growing evidence that certain cancers of the head ... strain of the human papillomavirus (HPV) that is one of ...
Cached Medicine News:Health News:It's Park Life for Edinburgh Students as Unite Unveils New Property Overlooking The Meadows 2Health News:It's Park Life for Edinburgh Students as Unite Unveils New Property Overlooking The Meadows 3Health News:It's Park Life for Edinburgh Students as Unite Unveils New Property Overlooking The Meadows 4Health News:Home Care Assistance's Exclusive Balanced Care Method(TM) Designed to Promote Longer, Healthier Lives 2Health News:Home Care Assistance's Exclusive Balanced Care Method(TM) Designed to Promote Longer, Healthier Lives 3Health News:Bioniche Phase III Clinical Trial with Urocidin(TM) Progressing Well 2Health News:Bioniche Phase III Clinical Trial with Urocidin(TM) Progressing Well 3Health News:Looks, Money, Fame Don't Bring Happiness 2Health News:Sexually Transmitted HPV Linked to Certain Head & Neck Cancers 2Health News:Sexually Transmitted HPV Linked to Certain Head & Neck Cancers 3
(Date:7/31/2015)... , July 31, 2015  Physicians and payers ... the biopharmaceutical market. Patients are better informed and ... and switching therapies. This shift in power is ... efforts toward patient-focused marketing. As part ... have learned it,s important to educate, communicate and ...
(Date:7/31/2015)... , July 31, 2015 More than 1,500 ... country will convene in Indianapolis ... 2015 Mid-Year Training Institute . The week-long training, ... to address one of our nation,s biggest public health ... Mid-Year Training Institute is a one-of-a-kind intensive training opportunity, ...
(Date:7/31/2015)... -- The Physician-Patient Alliance for Health & Safety ... "Surviving Your Hospital Stay: Physician-Patient Alliance for Health ... A sentence was omitted from the release. ... is a member of the National Coalition to Promote ... the National Coalition to Promote Continuous Monitoring of Patients ...
Breaking Medicine Technology:Consumers Forcing Pharmaceutical Industry to Shift its Marketing Focus from Products to Patients 2Community Leaders From Across The Country Head To Indianapolis For CADCA 2015 Mid-Year Training Institute Aug. 2-6 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: