Navigation Links
Folk Medicine Therapy May Prevent Alcoholic Relapse
Date:8/12/2009

Study in rodents used synthetic form of substance found in the kudzu vine

WEDNESDAY, Aug. 12 (HealthDay News) -- A synthetic form of a substance found in the kudzu vine can reduce drinking among alcoholics and help prevent relapse, a new study suggests.

Daidzin, the substance in kudzu, has long been used in traditional Chinese folk medicine to treat alcoholism. It inhibits human aldeyhyde dehydrogenase 2 (ALDH-2), which metabolizes alcohol into acetaldehyde. This results in an accumulation of acetaldehyde, which has unpleasant effects that include a flushing reaction and feeling ill, according to background information in a news release from Alcoholism: Clinical & Experimental Research, which is publishing the findings online and in its November print issue.

In the study, researchers found that a synthetic ALDH-2 inhibitor called CVT-10216 reduced drinking and prevented relapse in rodents. CVT-10216 increased acetaldehyde while the rodents were drinking alcohol and later decreased dopamine in the brain region that controls relapse during abstinence.

"We had several key findings," the study's corresponding author, Ivan Diamond, vice president of neuroscience at Gilead Science and professor emeritus of neurology, cellular and molecular pharmacology and neuroscience at the University of California, San Francisco, said in the news release.

"We found that, one, CVT-10216 is a highly selective reversible inhibitor of ALDH2 without apparent toxicity," Diamond said. "This means that it does not cause serious damage to other proteins and functions. Two, treatment with our ALDH-2 inhibitor increases acetaldehyde in the test tube and in living animals. And three, we found that our ALDH-2 inhibitor suppresses drinking in a variety of rodent drinking models."

Most importantly, he said, they "also found that CVT-10216 prevents the usual increase in drinking (binge drinking) that occurs after fi
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Annals of Internal Medicine tip sheet for Aug. 21, 2007, issue
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
4. £5 million investment in personalized medicines to cut patient deaths
5. The New England Journal of Medicine Publishes EURIDIS/ADONIS Study Results Showing Dronedarone Maintained Sinus Rhythm in Patients With Atrial Fibrillation or Flutter With no Observed Pro-Arrhythmia
6. Temple Emergency Medicine receives $1.8M to find best MRSA treatment
7. Medical, technological advances prompt updating of nuclear medicine technologists scope of practice
8. Nuclear medicine approach can be first choice for excluding pulmonary embolism in young women
9. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
10. Boston University School of Medicine researcher recipient of Memory Ride Grant
11. John B. Buse, MD, PhD of Chapel Hill, NC, Elected American Diabetes Association President, Medicine & Science
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Folk Medicine Therapy May Prevent Alcoholic Relapse
(Date:4/23/2014)... Fairfax, Va., April 23, 2014 The American Society ... guideline, "The Role of Postoperative Radiation Therapy for ... the use of adjuvant radiation therapy in the ... is published in the May-June 2014 issue of ... clinical practice journal of ASTRO. The full-length guideline ...
(Date:4/23/2014)... University researchers have developed a way to detect and ... tiny gold particles with tails of synthetic DNA., A ... biological engineering, used gold nanoparticles to target and bind ... RNA splice variants, which can indicate the presence and ... splice variants in a cell can be determined by ...
(Date:4/23/2014)... A novel compound that targets an important brain ... cocaine addiction behaviors, including relapse behavior, a University at ... strong evidence that this may be a novel lead ... medications exist., The UB research was published as an ... , In the study, the compound, RO5263397, severely blunted ...
(Date:4/23/2014)... 23, 2014Men whose testosterone falls below normal levels are ... overweight and have heart disease and type 2 diabetes. ... men for further testing and possible treatment is described ... , a peer-reviewed publication from Mary Ann Liebert, Inc., ... Journal of Men,s Health website at http://www.liebertpub.com/jmh ...
(Date:4/23/2014)... methods that can rapidly screen a large cell ... inside that population has been seriously lacking," said ... the Royal Society of Chemistry journal Chemical ... his coworkers have developed a novel technique that ... Chem. Sci. , 2014, DOI: 10.1039/C4SC00578C, http://pubs.rsc.org/en/content/articlelanding/2014/sc/c4sc00578c#!divAbstract ...
Breaking Medicine News(10 mins):Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 2Health News:ASTRO issues guideline on the role of postoperative radiation therapy for endometrial cancer 3Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2Health News:Novel compound halts cocaine addiction and relapse behaviors 2Health News:Following a protein's travel inside cells is key to improving patient monitoring, drug development 2
... ACM Technology To Make Medical Pharmacy Claims Processing ... announced today the signing of,a new three-year contract ... it,easier for providers to submit claims for complex ... health plan. ACM,s proprietary,e-Precision claims(SM) technology will streamline ...
... 15 Althea Technologies, Inc., a leading,provider ... and manufacturing, announced today that E.J. Brandreth ... Quality and Regulatory. In this,role, Mr. Brandreth ... and,compliance programs, while overseeing the regulatory support ...
... recently held its 2008 Live Group Buy for Magnetic Resonance Imaging ... Hitachi Medical Systems America Inc. , ... Dallas, TX ... Group Buy for Magnetic Resonance Imaging (MRI), and Broadlane’s clients awarded ...
... Financial District Office Workers, Celebrities, Sports Personalities, and Corporate CEO's, are ... , ... San Francisco (PRWEB) July 15, 2008 -- ... United States has chosen Peacock Construction to bring his ...
... E-Prescribing Solution Can Help Organizations Achieve Benefits of H.R. 6331 ... ... Netsmart Technologies, Inc., a leading provider of enterprise-wide software and services ... special Web seminar to help behavioral health organizations understand e-prescribing ...
... ANGELES (STRICTLY EMBARGOED UNTIL JULY 15, 2008 AT 12:01 A.M. ... cell vaccine designed to fight malignant brain tumors called glioblastoma ... a patient,s immune response and clinical outcome, according to an ... Cancer Research . , While other studies have suggested a ...
Cached Medicine News:Health News:Blue Shield of California and ACM Sign New 3-Year Agreement 2Health News:Althea Technologies Appoints E.J. Brandreth to Vice President of Quality and Regulatory 2Health News:Broadlane's Live Group Buy Awards High-Field Open MRI Contract to Hitachi Medical Systems America Inc. 2Health News:Broadlane's Live Group Buy Awards High-Field Open MRI Contract to Hitachi Medical Systems America Inc. 3Health News:Broadlane's Live Group Buy Awards High-Field Open MRI Contract to Hitachi Medical Systems America Inc. 4Health News:Construction Begins on Executive Express Chiropractic at the SF Embarcadero Center 2Health News:Netsmart Technologies Web Seminar Helps Behavioral Health Organizations Understand Electronic Prescribing And The Importance Of New Medicare-Related E-Prescribing Legislation 2Health News:Netsmart Technologies Web Seminar Helps Behavioral Health Organizations Understand Electronic Prescribing And The Importance Of New Medicare-Related E-Prescribing Legislation 3Health News:Brain cancer study: Magnitude of post-vaccine immune response linked to clinical outcomes 2Health News:Brain cancer study: Magnitude of post-vaccine immune response linked to clinical outcomes 3
(Date:1/15/2014)... 2014 Reportlinker.com announces that a new ... catalogue: Global Markets ... -- Focus on End Users ... A drug delivery system is ...
(Date:1/15/2014)... Mass. , Jan. 15, 2014  Zafgen, Inc., ... unmet needs of severely obese patients, today announced ... beloranib, a selective inhibitor of methionine aminopeptidase 2 ... severe form of genetic obesity.  These results showed ...
(Date:1/14/2014)... , Jan. 14, 2014 HeartWare International, Inc ... of less invasive, miniaturized circulatory support technologies that are ... that it expects revenues for the fourth quarter of ... 2013 revenues to approximately $208 million. "Our ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 2HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 3HeartWare International Announces Preliminary Fourth Quarter 2013 Revenues 4
Part of the Octopus System which includes both the Starfish & Octopus3. The Starfish Heart Positioner simplifies cardiac positioning and minimizes the associated hemodynamic deterioration when compa...
... way to lift the heart - Guidant's ... 3. The XPOSE 3 is designed to ... surgery and to easily position and access ... both apical and non-apical placement on the ...
... Since its U.S. approval in 1992, ABIOMED's ... widely used advanced cardiac assist system in the ... only device approved by the U.S. Food and ... heart failure. ABIOMED continues to make advances ...
... The Arrow LionHeart Left Ventricular Assist ... is designed to be used as a ... end-stage (Class IV) congestive heart failure, for ... The Arrow LionHeart LVAS is not intended ...
Medicine Products: