Navigation Links
Folk Medicine Therapy May Prevent Alcoholic Relapse
Date:8/12/2009

Study in rodents used synthetic form of substance found in the kudzu vine

WEDNESDAY, Aug. 12 (HealthDay News) -- A synthetic form of a substance found in the kudzu vine can reduce drinking among alcoholics and help prevent relapse, a new study suggests.

Daidzin, the substance in kudzu, has long been used in traditional Chinese folk medicine to treat alcoholism. It inhibits human aldeyhyde dehydrogenase 2 (ALDH-2), which metabolizes alcohol into acetaldehyde. This results in an accumulation of acetaldehyde, which has unpleasant effects that include a flushing reaction and feeling ill, according to background information in a news release from Alcoholism: Clinical & Experimental Research, which is publishing the findings online and in its November print issue.

In the study, researchers found that a synthetic ALDH-2 inhibitor called CVT-10216 reduced drinking and prevented relapse in rodents. CVT-10216 increased acetaldehyde while the rodents were drinking alcohol and later decreased dopamine in the brain region that controls relapse during abstinence.

"We had several key findings," the study's corresponding author, Ivan Diamond, vice president of neuroscience at Gilead Science and professor emeritus of neurology, cellular and molecular pharmacology and neuroscience at the University of California, San Francisco, said in the news release.

"We found that, one, CVT-10216 is a highly selective reversible inhibitor of ALDH2 without apparent toxicity," Diamond said. "This means that it does not cause serious damage to other proteins and functions. Two, treatment with our ALDH-2 inhibitor increases acetaldehyde in the test tube and in living animals. And three, we found that our ALDH-2 inhibitor suppresses drinking in a variety of rodent drinking models."

Most importantly, he said, they "also found that CVT-10216 prevents the usual increase in drinking (binge drinking) that occurs after five days of abstinence, and also prevents relapse to drink, even when alcohol is not present."

Diamond added, "This means that something else besides acetaldehyde helps to suppress craving for, and prevent relapse to, drinking alcohol. We believe that 'something else' is dopamine."

More information

The American Psychological Association has more about treating alcohol-related disorders.



-- Robert Preidt



SOURCE: Alcoholism: Clinical & Experimental Research, news release, Aug. 11, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Annals of Internal Medicine tip sheet for Aug. 21, 2007, issue
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
4. £5 million investment in personalized medicines to cut patient deaths
5. The New England Journal of Medicine Publishes EURIDIS/ADONIS Study Results Showing Dronedarone Maintained Sinus Rhythm in Patients With Atrial Fibrillation or Flutter With no Observed Pro-Arrhythmia
6. Temple Emergency Medicine receives $1.8M to find best MRSA treatment
7. Medical, technological advances prompt updating of nuclear medicine technologists scope of practice
8. Nuclear medicine approach can be first choice for excluding pulmonary embolism in young women
9. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
10. Boston University School of Medicine researcher recipient of Memory Ride Grant
11. John B. Buse, MD, PhD of Chapel Hill, NC, Elected American Diabetes Association President, Medicine & Science
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Folk Medicine Therapy May Prevent Alcoholic Relapse
(Date:8/18/2017)... ... August 18, 2017 , ... Mediaplanet today announces the launch ... lifestyles and highlighting the importance of proactive eye and ear health. The campaign ... latest innovations in hearing aid technology. , In this issue, the American ...
(Date:8/18/2017)... ... 18, 2017 , ... Radabaugh & Associates, a family managed ... North-Central West Virginia, is embarking on a cooperative charity effort with the Chestnut ... The Chestnut Mountain Ranch (CMR) is a Christ-centered boarding school for young men ...
(Date:8/18/2017)... ... August 18, 2017 , ... Goss & Associates Insurance Agency, ... commercial clients in the greater Houston region, is helping locally recognized nonprofit Addi’s ... against cancer. , Founded by Tony and Amber Bender after losing their young ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... says will lift the veil on false teachings pertaining to the mother of the Savior ... teach, you see a far different picture of the role of this historical woman. ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Our Mountains to Climb: A ... a couple that grew stronger together through the faith they shared to overcome struggles ... is the creation of published author, Barbara J. Corcoran, a retired teacher and happily ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... (NYSE: DPLO), the nation,s largest independent specialty pharmacy, announced financial ... unless otherwise noted, are to the quarter ended June 30, ... 2017 Highlights include: Revenue of $1,126 ... Total prescriptions dispensed of 220,000, compared to 241,000 ... Gross profit per prescription dispensed of $371, ...
(Date:8/4/2017)... , Aug. 3, 2017  Agragen, LLC, ... company active in the biopharmaceutical, nutraceutical, and aquacultural ... development of its lead drug candidates, AGR131.  This ... proinflammatory cytokine from the blood of patients suffering ... and inflammatory bowel disease. ...
(Date:8/2/2017)... , Aug. 2, 2017   Marshall County Hospital in Benton, Kentucky ... reduce the risk of hospital-acquired infections (HAIs). The new addition, Tru-D SmartUVC , short ... to kill deadly pathogens such as C. diff , MRSA, MERS, Ebola and more. ... Tru-D SmartUVC ... Tru-D in action in a patient room ...
Breaking Medicine Technology: