Navigation Links
Folk Medicine Therapy May Prevent Alcoholic Relapse

Study in rodents used synthetic form of substance found in the kudzu vine

WEDNESDAY, Aug. 12 (HealthDay News) -- A synthetic form of a substance found in the kudzu vine can reduce drinking among alcoholics and help prevent relapse, a new study suggests.

Daidzin, the substance in kudzu, has long been used in traditional Chinese folk medicine to treat alcoholism. It inhibits human aldeyhyde dehydrogenase 2 (ALDH-2), which metabolizes alcohol into acetaldehyde. This results in an accumulation of acetaldehyde, which has unpleasant effects that include a flushing reaction and feeling ill, according to background information in a news release from Alcoholism: Clinical & Experimental Research, which is publishing the findings online and in its November print issue.

In the study, researchers found that a synthetic ALDH-2 inhibitor called CVT-10216 reduced drinking and prevented relapse in rodents. CVT-10216 increased acetaldehyde while the rodents were drinking alcohol and later decreased dopamine in the brain region that controls relapse during abstinence.

"We had several key findings," the study's corresponding author, Ivan Diamond, vice president of neuroscience at Gilead Science and professor emeritus of neurology, cellular and molecular pharmacology and neuroscience at the University of California, San Francisco, said in the news release.

"We found that, one, CVT-10216 is a highly selective reversible inhibitor of ALDH2 without apparent toxicity," Diamond said. "This means that it does not cause serious damage to other proteins and functions. Two, treatment with our ALDH-2 inhibitor increases acetaldehyde in the test tube and in living animals. And three, we found that our ALDH-2 inhibitor suppresses drinking in a variety of rodent drinking models."

Most importantly, he said, they "also found that CVT-10216 prevents the usual increase in drinking (binge drinking) that occurs after five days of abstinence, and also prevents relapse to drink, even when alcohol is not present."

Diamond added, "This means that something else besides acetaldehyde helps to suppress craving for, and prevent relapse to, drinking alcohol. We believe that 'something else' is dopamine."

More information

The American Psychological Association has more about treating alcohol-related disorders.

-- Robert Preidt

SOURCE: Alcoholism: Clinical & Experimental Research, news release, Aug. 11, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Annals of Internal Medicine tip sheet for Aug. 21, 2007, issue
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
4. £5 million investment in personalized medicines to cut patient deaths
5. The New England Journal of Medicine Publishes EURIDIS/ADONIS Study Results Showing Dronedarone Maintained Sinus Rhythm in Patients With Atrial Fibrillation or Flutter With no Observed Pro-Arrhythmia
6. Temple Emergency Medicine receives $1.8M to find best MRSA treatment
7. Medical, technological advances prompt updating of nuclear medicine technologists scope of practice
8. Nuclear medicine approach can be first choice for excluding pulmonary embolism in young women
9. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
10. Boston University School of Medicine researcher recipient of Memory Ride Grant
11. John B. Buse, MD, PhD of Chapel Hill, NC, Elected American Diabetes Association President, Medicine & Science
Post Your Comments:
Related Image:
Folk Medicine Therapy May Prevent Alcoholic Relapse
(Date:6/26/2016)... ... ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center for ... Table in Battle Creek, MI, where the rehabilitation facility is located. This annual celebration ... world’s leading providers of cereal and other breakfast foods. Its residents often refer to ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many ... been diagnosed with endometriosis. These women need a treatment plan to not only ... approach that can help for preservation of fertility and ultimately achieving a pregnancy. ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
Breaking Medicine Technology: