Navigation Links
Folk Medicine Therapy May Prevent Alcoholic Relapse
Date:8/12/2009

Study in rodents used synthetic form of substance found in the kudzu vine

WEDNESDAY, Aug. 12 (HealthDay News) -- A synthetic form of a substance found in the kudzu vine can reduce drinking among alcoholics and help prevent relapse, a new study suggests.

Daidzin, the substance in kudzu, has long been used in traditional Chinese folk medicine to treat alcoholism. It inhibits human aldeyhyde dehydrogenase 2 (ALDH-2), which metabolizes alcohol into acetaldehyde. This results in an accumulation of acetaldehyde, which has unpleasant effects that include a flushing reaction and feeling ill, according to background information in a news release from Alcoholism: Clinical & Experimental Research, which is publishing the findings online and in its November print issue.

In the study, researchers found that a synthetic ALDH-2 inhibitor called CVT-10216 reduced drinking and prevented relapse in rodents. CVT-10216 increased acetaldehyde while the rodents were drinking alcohol and later decreased dopamine in the brain region that controls relapse during abstinence.

"We had several key findings," the study's corresponding author, Ivan Diamond, vice president of neuroscience at Gilead Science and professor emeritus of neurology, cellular and molecular pharmacology and neuroscience at the University of California, San Francisco, said in the news release.

"We found that, one, CVT-10216 is a highly selective reversible inhibitor of ALDH2 without apparent toxicity," Diamond said. "This means that it does not cause serious damage to other proteins and functions. Two, treatment with our ALDH-2 inhibitor increases acetaldehyde in the test tube and in living animals. And three, we found that our ALDH-2 inhibitor suppresses drinking in a variety of rodent drinking models."

Most importantly, he said, they "also found that CVT-10216 prevents the usual increase in drinking (binge drinking) that occurs after five days of abstinence, and also prevents relapse to drink, even when alcohol is not present."

Diamond added, "This means that something else besides acetaldehyde helps to suppress craving for, and prevent relapse to, drinking alcohol. We believe that 'something else' is dopamine."

More information

The American Psychological Association has more about treating alcohol-related disorders.



-- Robert Preidt



SOURCE: Alcoholism: Clinical & Experimental Research, news release, Aug. 11, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Annals of Internal Medicine tip sheet for Aug. 21, 2007, issue
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
4. £5 million investment in personalized medicines to cut patient deaths
5. The New England Journal of Medicine Publishes EURIDIS/ADONIS Study Results Showing Dronedarone Maintained Sinus Rhythm in Patients With Atrial Fibrillation or Flutter With no Observed Pro-Arrhythmia
6. Temple Emergency Medicine receives $1.8M to find best MRSA treatment
7. Medical, technological advances prompt updating of nuclear medicine technologists scope of practice
8. Nuclear medicine approach can be first choice for excluding pulmonary embolism in young women
9. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
10. Boston University School of Medicine researcher recipient of Memory Ride Grant
11. John B. Buse, MD, PhD of Chapel Hill, NC, Elected American Diabetes Association President, Medicine & Science
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Folk Medicine Therapy May Prevent Alcoholic Relapse
(Date:6/27/2016)... Dublin, CA (PRWEB) , ... June 27, 2016 ... ... Community College District , the only authorized OSHA Training Institute Education Center headquartered ... illness by protecting their workers from extreme heat at their worksites. Employers ...
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal ... Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Cut Pro X users can now reveal the media of their split screens ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... health professionals, announced today its affiliation with Tennessee Counseling Association. This ... the network of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. ...
(Date:6/27/2016)... (PRWEB) , ... June 27, ... ... in the patient payment industry today announced its strategic partnership with Connance, ... system workflows. , The two companies’ proven, proprietary technology combine to provide ...
(Date:6/27/2016)... ... 2016 , ... A revolution is underway. Brooklyn-based company, ... for the millions of people who require these medical transport services annually. ... the use of technology. Now, SmartEMS has put forth an industry-changing app that ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 26, 2016 One of Australia,s ... the formation of a new biotechnology company, Noxopharm Limited [ABN 50 ... an IPO and to list on the ASX. Noxopharm ... ready to enter a Phase 1 clinical study later this year. ... address one of the biggest problems facing cancer patients - the ...
(Date:6/26/2016)... -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ ) ... Improvements Act of 1976, as amended ("HSR"), with respect ... Nasdaq: CPXX ) expired effective June 24, ... As previously announced on May 31, 2016, Jazz Pharmaceuticals ... which Jazz Pharmaceuticals has commenced a tender offer for ...
(Date:6/26/2016)...  VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) reported ... required to build a strong and stable market for ... on the OTC Markets-pink current trading platform. ... are seeing an anomaly in market trading activities that ... the Company, but shareholders and market players as well. ...
Breaking Medicine Technology: