Navigation Links
Folk Medicine Therapy May Prevent Alcoholic Relapse
Date:8/12/2009

Study in rodents used synthetic form of substance found in the kudzu vine

WEDNESDAY, Aug. 12 (HealthDay News) -- A synthetic form of a substance found in the kudzu vine can reduce drinking among alcoholics and help prevent relapse, a new study suggests.

Daidzin, the substance in kudzu, has long been used in traditional Chinese folk medicine to treat alcoholism. It inhibits human aldeyhyde dehydrogenase 2 (ALDH-2), which metabolizes alcohol into acetaldehyde. This results in an accumulation of acetaldehyde, which has unpleasant effects that include a flushing reaction and feeling ill, according to background information in a news release from Alcoholism: Clinical & Experimental Research, which is publishing the findings online and in its November print issue.

In the study, researchers found that a synthetic ALDH-2 inhibitor called CVT-10216 reduced drinking and prevented relapse in rodents. CVT-10216 increased acetaldehyde while the rodents were drinking alcohol and later decreased dopamine in the brain region that controls relapse during abstinence.

"We had several key findings," the study's corresponding author, Ivan Diamond, vice president of neuroscience at Gilead Science and professor emeritus of neurology, cellular and molecular pharmacology and neuroscience at the University of California, San Francisco, said in the news release.

"We found that, one, CVT-10216 is a highly selective reversible inhibitor of ALDH2 without apparent toxicity," Diamond said. "This means that it does not cause serious damage to other proteins and functions. Two, treatment with our ALDH-2 inhibitor increases acetaldehyde in the test tube and in living animals. And three, we found that our ALDH-2 inhibitor suppresses drinking in a variety of rodent drinking models."

Most importantly, he said, they "also found that CVT-10216 prevents the usual increase in drinking (binge drinking) that occurs after five days of abstinence, and also prevents relapse to drink, even when alcohol is not present."

Diamond added, "This means that something else besides acetaldehyde helps to suppress craving for, and prevent relapse to, drinking alcohol. We believe that 'something else' is dopamine."

More information

The American Psychological Association has more about treating alcohol-related disorders.



-- Robert Preidt



SOURCE: Alcoholism: Clinical & Experimental Research, news release, Aug. 11, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Annals of Internal Medicine tip sheet for Aug. 21, 2007, issue
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. FDA Seeks to Regulate Complementary and Alternative Medicine; Products Such as Vegetable Juice Could Be Restricted for Medical Use
4. £5 million investment in personalized medicines to cut patient deaths
5. The New England Journal of Medicine Publishes EURIDIS/ADONIS Study Results Showing Dronedarone Maintained Sinus Rhythm in Patients With Atrial Fibrillation or Flutter With no Observed Pro-Arrhythmia
6. Temple Emergency Medicine receives $1.8M to find best MRSA treatment
7. Medical, technological advances prompt updating of nuclear medicine technologists scope of practice
8. Nuclear medicine approach can be first choice for excluding pulmonary embolism in young women
9. University of Nevada School of Medicine Professor Confirms Accuracy Through Validation Study Using the CSI Health Station Model 6K
10. Boston University School of Medicine researcher recipient of Memory Ride Grant
11. John B. Buse, MD, PhD of Chapel Hill, NC, Elected American Diabetes Association President, Medicine & Science
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Folk Medicine Therapy May Prevent Alcoholic Relapse
(Date:6/26/2017)... ... 26, 2017 , ... Antoine Dental Center is now offering various types of dental ... act as a support for prosthetic teeth, such as crowns, bridges, or dentures. An implant ... a sturdy, lasting new root for the tooth. , Several types of dental implants ...
(Date:6/26/2017)... ... June 26, 2017 , ... ... is revolutionizing the way women look and feel about themselves and their sexual ... female sexual dysfunction and urinary leakage head on with a ground breaking medical ...
(Date:6/26/2017)... ... ... New patients with missing teeth in Fitchburg, WI, can now receive ... is a trusted dentist who has placed many dental implants and enjoys teaching patients ... in Fitchburg, WI, are encouraged to find out if they are candidates for dental ...
(Date:6/25/2017)... Santa Rosa, CA (PRWEB) , ... June 25, 2017 , ... ... lot more green and growing foliage and plants, and along with that; a humdinger ... pollen sensitive allergy sufferers, it also means an increase in misery-causing grass and weed ...
(Date:6/24/2017)... ... June 24, 2017 , ... Genes Advice, ... medications in select Florida and Texas doctors' offices and clinics. This breakthrough testing ... of genetic testing recognizes the role genes play in determining an individual's tolerance ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... 2017 Therapix Biosciences Ltd. (Nasdaq: TRPX), ... the development of cannabinoid-based drugs, today announced that ... at three upcoming scientific and investor conferences in ... Invitational: ...                     Wednesday, June ...
(Date:5/24/2017)... HAMPTON, Va. , May 24, 2017 /PRNewswire/ ... ivWatch Original Equipment Manufacturer (OEM) Board to enable ... technology with patient monitoring systems, infusion pumps and ... products, OEMs will be able to help health ... care and reduced risks related to IV therapy. ...
(Date:5/18/2017)... , May 18, 2017  Two Bayer U.S. ... Association (HBA) during its recent 28 th ... City.  The event showcases HBA,s longstanding mission of furthering ... of healthcare. Cindy Powell-Steffen , senior ... U.S. Radiology division, and Libby Howe , a ...
Breaking Medicine Technology: