Navigation Links
Folic acid supplements in early pregnancy may reduce the risk of severe language delay in children
Date:10/12/2011

October 12, 2011-- Research has established that taking folic acid supplements during pregnancy reduces the risk of bearing a child with neural tube defects, but little is known about the relationship between prenatal folic acid and neurodevelopment after birth. A collaborative study between investigators at the Norwegian Institute of Public Health and Columbia University's Mailman School of Public Health has now reported that mothers who took folic acid supplements from 4 weeks before to 8 weeks after conception reported a significantly lower prevalence of severe language delay in their children at age 3. The study was based in a unique Norwegian pregnancy cohort often referred to as "MoBa".

The full study findings are published online in the October 12 issue of JAMA.

The current analysis included 19,956 boys and 18,998 girls. Of these children, 204 (0.5%) were rated as having severe language delay, defined as minimal expressive language, only 1-word or unintelligible utterances. Among women who took folic acid supplements in early pregnancy, the reported prevalence of such delay was 0.4%, but among the approximately 9,000 children whose mothers took no folic acid, the delay was more than twice as common: 0.9% (81 children).

Across the entire sample, severe language delays were four times more common in boys than girls, as is typically the case.

"Unlike the United States, Norway does not fortify foods with folic acida fact that increases the contrast between women who do and do not take folic acid supplements and makes Norway a good place to study this effect," noted lead author Christine Roth, Clin.Psy.D., MSc, of the Division of Mental Health at the Norwegian Institute of Public Health, Oslo and a visiting researcher at the Mailman School. "If in future research this relationship were shown to be causal, it would have important implications for understanding the biological processes underlying disrupted neurodevelopment, for the prevention of neurodevelopmental disorders, and for policies of folic acid supplementation for women of reproductive age," said senior author Dr. Susser, director of the Imprints Center for Genetic and Environmental Life Course Studies, of the Mailman School of Public Health and the New York State Psychiatric Institute.

Pregnant women were recruited for the study beginning in 1999, and data were included on children born before 2008 whose mothers returned the 3-year follow-up questionnaire by June 2010. The primary outcome measured for the study was children's language competency at age 3 years as gauged by maternal report on a 6-point ordinal language grammar scale.

Researchers also looked at gross motor skills at age 3 and found no relationship between significant motor delays and prenatal folic acid. "This provides some reassurance that there is not confounding by an unmeasured factor," the authors observed. "Such a factor might be expected to relate to both language and motor delay."

The study, if corroborated by further research, could help further scientific understanding of the biology of language development. The researchers plan to pursue this question further with stringent tests of whether the relationship is causal, studies of the hypothesized mechanisms, and detailed follow-ups of the children at age 5.


'/>"/>

Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health
Source:Eurekalert

Related medicine news :

1. Folic Acid in Pregnancy May Prevent Kids Language Delays
2. Higher Folic Acid Levels in Teens Tied to Academic Success
3. Folic acid given to mother rats protects offspring from colon cancer
4. Folic acid for everybody -- arguments in favor of food fortification
5. No Heart Benefit Seen From Folic Acid Supplements
6. Ginger Supplements Might Ease Inflammation Linked to Colon Cancer
7. Herbal supplements may cause dangerous drug interactions in orthopaedic surgery patients
8. Dietary Supplements May Harm Older Women: Study
9. Certain dietary supplements associated with increased risk of death in older women
10. Omega-3 Supplements Dont Help, May Hurt ICU Patients
11. Dietary supplements for patients after lung injury do not appear to improve outcomes; may be harmful
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , ... June 27, 2016 , ... ... mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... to the network of the Tennessee Counseling Association, adding exclusive benefits and promotional ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... ... 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop ... The fitness app plans to fix the two major problems leading the fitness industry today:, ... all type program , They don’t eliminate all the reasons people quit their ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 ... brings up a new, often overlooked aspect of head lice: the parasite’s ability to live ... not a common occurrence, but a necessary one in the event that lice have simply ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... -- Story Highlights: , ... health care industry is causing providers to review operating ... offers a suite of solutions for health care providers ... optimization: labor resource analysis, revenue cycle optimization and physician ... and better economics ...
(Date:6/24/2016)...  Collagen Matrix, Inc., ("Collagen Matrix") the driving ... collagen and mineral based medical devices for tissue ... Messer has joined the company as Vice ... growing portfolio of oral surgery, neurosurgery, orthopaedic and ... the Collagen Matrix executive team as an accomplished ...
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
Breaking Medicine Technology: