Navigation Links
Folic acid deficiency has multigenerational effects
Date:9/27/2013

thereby causing developmental problems.

Dr. Roy Gravel, also a co-author of the study and member of the Alberta Childrens' Hospital Research Institute says this study provides a tremendous opportunity to look at the prevention of diseases like spina bifida. "The work began as a study of a gene called Mtrr in mice. The goal was to shed light on how a mutation in Mtrr would affect folate metabolism. The multigeneral effect we observed was completely unexpected," says Gravel.

The Mtrr gene encodes an enzyme that is key to the metabolism of folic acid and, when mutated, causes similar effects to dietary folic acid deficiency. The researchers found that when either the maternal grandmother or the maternal grandfather had this Mtrr mutation, their genetically normal grandchildren were at risk of a wide spectrum of developmental abnormalities, even if the mutated gene was not inherited through to the next generations.

These developmental abnormalities were also seen in the fourth and fifth generations of mice.

Through a series of experiments, researchers discovered that the developmental abnormalities were not passed down genetically. Instead, the defects were the result of "epigenetic" changes, which had been inherited. Epigenetics is a process which turns genes on and off through chemical modifications to DNA without changing the genetic code itself. Epigenetic inheritance refers to the passing along of these epigenetic marks as cells divide during development. It had been previously thought that epigenetic modifications were, for the most part, 'wiped clean' after each generation.

The researchers hypothesize that, for a yet unknown reason, some of these abnormal epigenetic marks caused by the Mtrr mutation escape this normal erasure and are inherited by the next generation. If the abnormal epigenetic marks that regulate genes important for development are inherited, then these generations may develop abnormalities as a result of the wrong genes bein
'/>"/>

Contact: Gloria Visser-Niven
gvissern@ucalgary.ca
403-210-6615
University of Calgary
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Folic Acid Supplements Dont Affect Cancer Risk, Review Finds
2. Lower autism risk with folic acid supplements in pregnancy
3. Folic Acid in Pregnancy May Lower Autism Risk
4. Vitamin D deficiency and poorer lung function in asthmatic children treated with steroids
5. New Immune-Deficiency Illness Emerging in East Asia
6. Gestational exposure to urban air pollution linked to vitamin D deficiency in newborns
7. Health Issues Add to Risk of Vitamin D Deficiency, Study Says
8. Vitamin D deficiency linked to Type 1 diabetes
9. ZijaExtreme.com Researches Vitamin D Deficiency & Using a More Natural Approach
10. Vitamin deficiency screening needed for refugees
11. Deficiency in p53 anti-tumor protein delays DNA repair after radiation, Moffitt researchers say
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... 2014 Woodland Hills dental ... group of dental specialists who treat full mouth implant ... of Oviedo. Dr. Reshad of the Anacapa Dental Art ... on two continents, will give a full-day presentation Oct. ... reconstruction. , “These specialists want to improve their skills ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 Generic drug ... retail generics increasing in price in the last 12 ... Inc.’s (AIS) Drug Benefit News (DBN) interviewed a plan ... means for pharmacies and health plans. , “When ... rising generic acquisition costs, these cost increases squeeze pharmacies’ ...
(Date:10/1/2014)... insulin is safer and more effective than intermediate-acting ... to new research published in the BMJ ... twice-daily doses of both long- and intermediate-acting insulin, ... "In patients with Type 1 diabetes, we found ... when it came to controlling blood sugar, preventing ...
(Date:10/1/2014)... Looking for holiday gift ideas? Éminence Organic Skin ... giving easy this holiday season. Starting October 1st 2014, new ... all shopping dilemmas. Choose from two luxury skin care gift ... delicate eye area or to deliver whole body beauty. ... Duo Gift Set are formulated to suit all skin types ...
(Date:10/1/2014)... 01, 2014 To help raise awareness about ... Cutler Integrative Medicine, is detailing several tips for women looking ... According to Dr. Cutler, women should start each day with ... yourself that will help ‘center’ yourself for the rest of ... says. , Other health and fitness tips include:, -Drink ...
Breaking Medicine News(10 mins):Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 2Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 3Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 4Health News:Rising Generic Drug Prices Affect Pharmacies, Insurers Alike, Reports AIS Newsletter 2Health News:Rising Generic Drug Prices Affect Pharmacies, Insurers Alike, Reports AIS Newsletter 3Health News:Long-acting insulin is safer, more effective for patients with Type 1 diabetes 2Health News:Éminence Organic Skin Care Launches Limited Edition Spa Gift Sets for the Holiday Season 2Health News:Éminence Organic Skin Care Launches Limited Edition Spa Gift Sets for the Holiday Season 3Health News:In Recognition of National Women’s Health and Fitness Day, Cutler Integrative Medicine Details Tips for Living a Healthier and Happier Life 2
... routinely discarded placenta //might be a good source of stem ... of the journal Stem Cells. ,Researchers had found that ... of the amniotic sac have cells that are very similar ... two genes that make the embryonic stem cells unique in ...
... Researchers from Douglas Hospital Research Center in Montreal showed ... to deal with stressful situations than those who bottle-feed ... well established, this is for the first time findings ... as well. Researchers feel that this is good for ...
... 2005. Hormone Replacement Therapy (HRT) is commonly advocated in ... with increased chances of breast cancer and recently anxiety has ... Medical Journal// the cumulative risk of such a cancer developing ... as was previously reported. ,A team from New ...
... days when drinking was considered to be forbidden. It has ... ,A new research has found that drinking is not all ... reported to have better verbal skills, memory and speed of ... Moderate drinkers not only performed the best but also seemed ...
... wet hair may be far more effective treatment of ... used single blind randomized controlled trial for comparing the ... against head lice in United Kingdom. , ,Fine ... current over the counter chemical treatments for eliminating head ...
... The Food and Drug Administration FDA has recently ... prescription drug advertisements. ,The FDA and the ... practices for drugs, with agency research showing that ... benefits and do not adequately disclose risks. FDA's ...
Cached Medicine News:Health News:Researchers Gather Stem Cells From Discarded Placenta 2Health News:Breastfeeding Lowers Maternal Stress 2Health News:Risk of Breast Cancer Overestimated with Hormone Replacement Therapy(HRT) Treatment 2Health News:Yet Another Reason To Celebrate Drinking 2Health News:Combing Hair More Effective Than OTC Medicine For Head Lice 2
(Date:9/30/2014)... , Sept. 30, 2014  Wrightington, Wigan ... Allscripts (NASDAQ: MDRX ) are delighted to ... as WWL,s new health information system. The system will ... completely transform the way WWL delivers healthcare in the ... a demonstrated record of on-time and on-budget system implementations ...
(Date:9/30/2014)... 30, 2014 This study provides an ... informatics solutions including nuclear imaging informatics, PET imaging ... study assesses the size of the market based ... and projects future growth based on the current ... taking place in the broader markets for imaging ...
(Date:9/30/2014)... , Sept. 30, 2014  Decision Resources Group ... in Brazil , Russia ... China (BRIC) will see robust expansion ... increasingly favored over surgical procedures. Although revenues will be ... reimbursement challenges, prolonged device approval times and demand for ...
Breaking Medicine Technology:Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 2Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 3Wrightington, Wigan and Leigh NHS Foundation Trust selects Allscripts Sunrise 4Analysis of the US Molecular Imaging Informatics Market 2Analysis of the US Molecular Imaging Informatics Market 3Brazilian, Russian, Indian and Chinese Markets for Peripheral Vascular Devices Will See Strong Expansion Through 2023 2Brazilian, Russian, Indian and Chinese Markets for Peripheral Vascular Devices Will See Strong Expansion Through 2023 3
... Feb. 23, 2011 Roche (SIX: RO, ROG; OTCQX: RHHBY) ... Department of Defense (DOD) to provide remote service and support ... the DOD,s secure B2B gateway. Roche is the first in-vitro ... for this remote access. The B2B gateway is ...
... Feb. 23, 2011 Xenogenics Corporation ("Xenogenics"), a majority ... MCET), is pleased to announce it has retained the ... of its capital formation strategy to help finance expanded ... In animal testing and initial human use, the ...
Cached Medicine Technology:Roche Teams with Womack Army Medical Center to Become First IVD Manufacturer approved for Remote Network Connectivity with DOD 2Xenogenics Corporation Retains the Emmes Group to Advise on Fund Raising Efforts 2Xenogenics Corporation Retains the Emmes Group to Advise on Fund Raising Efforts 3Xenogenics Corporation Retains the Emmes Group to Advise on Fund Raising Efforts 4
Portable shields for your safety and convenience....
Provide 1.5mm protection throughout. Six durable, attractive vinyl coverings are available. Lead glass window factory installed. Larger window available....
Swing-Arm™ Scatter Shield® provides lower extremity protection for personnel close to the tube. 24"Wx32"L lead shield swings 180 along table. Ideal for cardiac cath, special studies, electr...
Front Protection with attached Belt Guard, Built-in Back Support; Buckle Closure...
Medicine Products: