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Folate receptors may serve as a front door to ovarian cancer treatment
Date:10/28/2011

ause there is no good screening test, such as the Pap smear for cervical cancer. After surgery and a round of chemotherapy, most women go into remission, but it's usually short-lived: about 70 percent of patients relapse within two years, Ghamande said. Physicians today often pair chemotherapeutic agents with biologic agents that bolster the immune response to try to improve outcomes. When women relapse or, inevitably, become platinum-resistant, they receive the chemotherapeutic agent Doxil.

The study compared, women receiving Doxil to those receiving Doxil as well as EC145. They found those with the most folate receptors on their cancer cells benefited the most from the new therapy: their progression-free survival went from 6.6 to 24 weeks, a 72 percent improvement from the standard therapy. "There is a proof of concept because the more folate receptors you overexpress, the better you do," Ghamande said.

Folate, or folic acid, is a B vitamin that is a basic component of cell metabolism and DNA synthesis and repair. Cancer cells, which are constantly multiplying and adapting, need more of it than healthy cells.

A larger Phase 3 study is underway internationally. The research was funded by Endocyte, Inc.


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Contact: Toni Baker
tbaker@georgiahealth.edu
706-721-4421
Georgia Health Sciences University
Source:Eurekalert  

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