Navigation Links
Flushing From Alcohol a Risk Factor for Esophageal Cancer
Date:3/24/2009

Recognizing the enzyme deficiency would save many lives, study suggests

TUESDAY, March 24 (HealthDay News) -- People who experience facial flushing when they drink alcohol are much more likely to develop alcohol-related esophageal cancer, say American and Japanese experts.

Facial flushing, nausea and increased heart rate when drinking alcohol occurs in about a third of East Asians (Chinese, Japanese and Koreans), mainly due to an inherited deficiency in an enzyme called aldehyde dehydrogenase 2 (ALDH2). There is increasing evidence that people with this deficiency are at much higher risk for alcohol-related esophageal cancer (specifically squamous cell carcinoma) than people with fully active ALDH2, the experts wrote in an article in this week's issue of PLoS Medicine.

However, many doctors and people with alcohol flushing response aren't aware of this increased risk. This lack of awareness is "unfortunate as esophageal cancer is one of the deadliest cancers worldwide, with five-year survival rates of 15.6 percent in the United States, 12.3 percent in Europe, and 31.6 percent in Japan," noted Dr. Philip Brooks and colleagues at the U.S. National Institute on Alcohol Abuse and Alcoholism, and Dr. Akira Yokoyama of the Kurihama Alcohol Center in Japan.

"Our goal in writing this article is to inform doctors firstly that their ALDH2-deficient patients have an increased risk for esophageal cancer if they drink moderate amounts of alcohol, and secondly that the alcohol flushing response is a biomarker for the ALDH2 deficiency," the researchers said in a news release from the journal.

ALDH2 deficiency can be determined by asking patients about previous episodes of alcohol-induced flushing, the experts said.

"As a result, ALDH2-deficient patients can then be counseled to reduce alcohol consumption, and high-risk patients can be assessed for endoscopic cancer screening," Brooks and colleagues said.

There are about 540 million ALDH2-deficient people worldwide, which means even a minor reduction in the rate of alcohol-related esophageal cancers would save a large number of lives.

More information

The American Cancer Society has more about esophageal cancer.



-- Robert Preidt



SOURCE: PLoS Medicine, news release, March 23, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Alcohol-induced flushing is a risk factor for esophageal cancer from alcohol consumption
2. FalconStor Software Inc. Founders Make Multi-Million Dollar Donation to North Shore-LIJ Health System for Asian Community Health Center in Flushing
3. Alcohol flush signals increased cancer risk among East Asians
4. Good Feelings From Alcohol Only Come With Fewer Drinks
5. Acetaldehyde in alcohol -- no longer just the chemical that causes a hangover
6. The Recovery Place Helps Hundreds of Patients Through Drug and Alcohol Rehabilitation
7. Affordable Drug and Alcohol Rehab Ranch Residence is Saving Lives in Washington
8. Shootings Linked to Alcohol-to-Go Outlets, Study Finds
9. The Rev. Joseph C. Martin, Leading Authority on Alcoholism and Addiction Treatment, Dies at 84
10. Media Images of Alcohol Can Drive You to Drink
11. Alcohol consumption may increase pancreatic cancer risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Flushing From Alcohol  a Risk Factor for Esophageal Cancer
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... 24, 2016 , ... A recent article published June 14 on ... article goes on to state that individuals are now more comfortable seeking to undergo ... such as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort ... holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain ... Disease (SCD) is a disorder of the red blood cells, which can cause episodes ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 ... care operating models within the health care industry is ... financial efficiency , Deloitte offers a suite of ... business issues impacting efficient cost optimization: labor resource analysis, ... These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
Breaking Medicine Technology: