Navigation Links
Fluorescent probes light up cancerous tumors
Date:2/16/2010

Building on his Nobel Prize-winning work creating fluorescent proteins that light up the inner workings of cells, a team of researchers led by Howard Hughes Medical Institute investigator Roger Tsien, PhD, professor of pharmacology, chemistry and biochemistry at the University of California, San Diego and the Moores UCSD Cancer Center has developed biological probes that can stick to and light up tumors in mice. The scientists were able to spot and remove more cancerous tissue in mice injected with the fluorescent probes than in those mice without the fluorescent probes, upping survival five-fold. The findings reported online the week of February 15 in the early edition of the Proceedings of the National Academy of Sciences are the latest steps in research aimed at helping surgeons see the outlines of cancerous tumors in real time, and promise to open new doors to using molecular tools in the operating room.

"The development of biological probes that can guide surgeons, rather than depending only on feel and normal 'white light' to see, can provide tools to navigate the body on a molecular level," said first author Quyen Nguyen, MD, PhD, assistant professor of surgery at the University of California, San Diego School of Medicine.

Surgeons often rely on feel, look and experience to tell if they have removed all of a tumor while sparing healthy tissue. While the patient lies on the operating table under anesthesia, tissue samples are quickly examined by pathologists, and remaining tumor tissue is sometimes missed, meaning further surgery or a greater likelihood of tumor recurrence. Tsien, Nguyen and colleagues used synthetic molecules called activatable cell penetrating peptides (ACPPs) and microscopic nanoparticles to develop probes carrying fluorescent and magnetic tags. These tags make tumors visible to MRI and allow the tumors to "glow" on the operating table. The team wanted to see if the probes could aid surgeons in seeing more of the
'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows
2. Naturally fluorescent molecules may serve as cancer biomarker
3. MBL scientist Osamu Shimomura wins Nobel Prize for discovery of green fluorescent protein
4. Fluorescent Retinal Cells Warn of Eye Disease
5. MEDRAD Multi Vendor Service Launches TotalRepair(SM) on Select Ultrasound Probes
6. Nanoscopic probes can track down and attack cancer cells
7. China Medical Technologies Announces the Receipt of SFDA Approval for Two of its FISH Probes and the Approval for the Hi-Tech Enterprise Status for its PRC Subsidiaries
8. Team probes why climbers die on Mount Everest
9. Study Probes Why Smokers Find It Hard to Quit
10. Study Probes Internet Health-Related Search Patterns
11. String probes for devastating childhood digestive disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... York, NY (PRWEB) September 23, 2014 ... a moderate rate over the past five years. Growth ... health consciousness has encouraged Canadians to consume more fish ... has encouraged food retailers and food-service establishments to increase ... increasing industry revenue. Additionally, strong economic growth in much ...
(Date:9/23/2014)... (PRWEB) September 23, 2014 Oaksterdam University ... Today . In its first post, the University addresses ... and changing cannabis industry. , The cannabis industry is ... alone is expecting an 18-month boost of more than ... adult use pot sales. And, the new legal recreational ...
(Date:9/23/2014)... "The primary purpose of the CALL LIGHT CADDY is patient ... "Call lights are often found on the floor, lost in ... out of the patient's reach. In order to make sure ... it, I created this caddy." , She developed the CALL ... easy reach. The accessory ensures that the call device can ...
(Date:9/23/2014)... The University of California, Davis, and Academia Sinica, ... China (Taiwan), have entered into a collaborative agreement ... program that couples cutting-edge research with opportunities to ... new companies. , The agreement was signed Sept.12 ... research at UC Davis and President Chi-Huey Wong ...
(Date:9/23/2014)... 23, 2014 AttorneyOne.com, a recognized authority ... latest information from the FDA on Jalapeno Bagels ... its Private Label Jalapeno Bagels are recalled as they ... Publix Jalapeno Bagels were sold in the self-service ... , Taking into consideration the latest developments, AttorneyOne.com monitor ...
Breaking Medicine News(10 mins):Health News:Fish and Seafood Wholesaling in Canada Industry Market Research Report Now Available from IBISWorld 2Health News:Fish and Seafood Wholesaling in Canada Industry Market Research Report Now Available from IBISWorld 3Health News:Oaksterdam University Addresses "Why Quality Training Matters in a Growing Marijuana Industry" in First Blog Post 2Health News:Oaksterdam University Addresses "Why Quality Training Matters in a Growing Marijuana Industry" in First Blog Post 3Health News:Academia Sinica, UC Davis sign agreement on exchanges and tech transfer 2Health News:Publix Private Label Jalapeno Bagels Recalled: AttorneyOne Monitors and Keeps Consumers Informed 2
... there, experts warn , SUNDAY, Sept. 16 (HealthDay News) ... States occur at home but are preventable, according to ... From cleaning products to coat hangers, the average American ... accidents. Americans can take simple steps, such as wearing ...
... Lifestyle Experts - Plus TV Style, Expert ... Patients Through Live ... 15 People suffering from painful and,at times, embarrassing, ... Foundation officially launched the 2007 PATH program,-- Psoriatic Arthritis ...
... trouble, experts say , , SATURDAY, Sept. 15 (HealthDay News) -- ... or severe stomach pain is another matter that could signal ... People with the following symptoms need to see a doctor: ... pain lasting for hours or days; , pain that wakes ...
... 14 Aid provided by,The Prem Rawat Foundation has ... and their families who were victims of the flooding,earlier ... the flooding, caused by cyclones in this area last ... from their homes. The,Prem Rawat Foundation made a grant ...
... Ill., Sept. 14 The Board of,Directors of ... distributor and,supplier of disposable gloves and other products ... announced it would file a,Form 15 on or ... Exchange,Commission to deregister the Company,s common stock and ...
... HOUSTON, Sept. 14 The following is a,Statement by Oscar S. Wyatt, Jr.: "I,ve seen ... any politicians who want to,return those funds received from me, please return them in the form ... ... DeBakey Medical Foundation ...
Cached Medicine News:Health News:Eye Safety Begins at Home 2Health News:Empowerment Program Gets Patients on the PATH to Managing the Physical and Emotional Effects of Psoriatic Arthritis 2Health News:Empowerment Program Gets Patients on the PATH to Managing the Physical and Emotional Effects of Psoriatic Arthritis 3Health News:The Prem Rawat Foundation Supports Disaster-Relief Efforts in Mozambique 2Health News:AHPC Holdings, Inc. Announces Intent to Deregister Common Stock With Securities and Exchange 2
(Date:9/23/2014)... Sept. 23, 2014   LabStyle Innovations Corp ... Management Solution, today announced that it has closed ... shares of preferred stock and warrants.  No placement ... offering expenses, LabStyle expects to secure net proceeds ... LabStyle intends to use the net ...
(Date:9/23/2014)... , Sept. 23, 2014   MedNet Solutions , ... management systems, is pleased to announce that it will once ... Data Management (SCDM) Annual Conference, to be held this year ... Vegas , Nevada. MedNet team members, in conjunction with representatives ... who will also be in attendance, will be providing ...
(Date:9/23/2014)... DUBLIN , Sept. 23, 2014 ... the "Company"), a biotechnology company pioneering the manufacturing ... in emerging nations, today announced that the Depository ... for DTC,s Deposit and Withdrawal at Custodian ("DWAC") ... ("FAST") transfer agent as the distribution point.  The ...
Breaking Medicine Technology:LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 2LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 3LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 4LabStyle Innovations Closes $4.2 Million Non-Brokered Private Placement Financing 5MedNet Solutions - Proud To Sponsor The SCDM 2014 Annual Conference 2TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 2TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 3TNI BioTech, Inc. Announces Its Stock is Now DTC DWAC/FAST Eligible 4
... 17, 2012  Amy Langan, Vice President of Marketing and ... its enhanced labeling for sterile intravenous compounded ... Critical Care Exposition, May 19-24, 2012 in Orlando, Florida. ... Langan invites critical care professionals to visit Booth #2668 ...
... FRANCISCO, May 17, 2012  Varian Medical Systems (NYSE: ... early-stage inoperable lung cancer and other conditions non-invasively at ... (ATS) later this week in San Francisco.  ... of pulmonologists who may not be familiar with radiosurgery ...
Cached Medicine Technology:PharMEDium Highlights Enhanced Labeling for ICU Services at Critical Care Expo 2Varian Medical Systems to Showcase Radiosurgery Technology for Non-invasive Treatment of Early Stage Inoperable Lung Cancer 2Varian Medical Systems to Showcase Radiosurgery Technology for Non-invasive Treatment of Early Stage Inoperable Lung Cancer 3Varian Medical Systems to Showcase Radiosurgery Technology for Non-invasive Treatment of Early Stage Inoperable Lung Cancer 4
... difficile Panel is an enzyme immunoassay used ... antigen (glutamate dehydrogenase) and toxin A in ... as an aid in the diagnosis of ... of the Triage Microbiology product line, designed ...
ELISA for the detection of C. difficile toxin A in stool specimens...
... fast, accurate, reliable and repeatable measurements. The ... excellent price. , , , Automatic ... Refractor provides highly accurate measurement of patients ... by pushing a button. Patient alignment is ...
... Tomey Pachymeter SP-3000 covers all needs regarding ... ophthalmic health care., ,Compact design, colored touch-screen ... to be an "easy-to-use unit.,The wide measurement ... gives you the possibility to measure very ...
Medicine Products: