Navigation Links
Fluorescent probe for oral cancer

UC Davis researchers have developed a laser probe for the early detection of oral cancer. A trial with human subjects shows that the device could also be used during surgery to locate the edges of a tumor.

Approximately 43,000 people in the U.S. are diagnosed with tumors of the mouth, pharynx and larynx each year. The main risk factor is smoking, but a recent rise in cases has been linked to human papillomavirus. Most cases are not diagnosed until the cancer has reached an advanced stage.

"There's a lot out there about breast, prostate and brain cancer, but people are not so aware about oral cancer and its devastating consequences," said Laura Marcu, a professor of biomedical engineering at UC Davis. "People don't think to look for it, and there isn't any routine screening."

Marcu's laboratory collaborated with Dr. Gregory Farwell's group in the Department of Otolaryngology at the UC Davis Cancer Center to develop the fiber-optic probe.

The probe stimulates molecules in the patient's tissues with a laser. Some of these molecules naturally respond by re-emitting fluorescent light. The device rapidly detects and analyzes this light using a process called "time-resolved fluorescence spectroscopy" (TR-LIFS), which provides information about the types of molecules present.

During surgery, blood can distort the intensity of the fluorescence signal but not its duration. By using sensitive measurements of the change in fluorescence over time, surgeons can see the tumor margins even as they are cutting the tissue.

Based on encouraging results in animal tests, Marcu and Farwell's team recruited nine human volunteers from among patients who arrived at the UC Davis Medical Center for surgical therapy of the mouth, throat and larynx. They compared readings from spectroscopy with biopsy samples from the same locations and found that the probe could accurately diagnose the cancer in the surgical environment.

The probe is similar to one that Marcu has already developed for use with brain tumors. In clinical trials, surgeons have used her technology to delineate the margins of tumors during surgery.

Details of the human oral cancer study were published in the June issue of the journal Otolaryngology - Head and Neck Surgery. The pilot study in patients was supported in part by the Cancer Center and the Clinical and Translational Science Center at the UC Davis School of Medicine and the UC Davis Center for Biophotonics Science and Technology.


Contact: Andy Fell
University of California - Davis - Health System

Related medicine news :

1. Replacing hydrogen in fluorescent dyes improves detection ability, stability and shelf life
2. Fluorescent probes light up cancerous tumors
3. Study Probes Causes of Anger in Returning U.S. Soldiers
4. PET scanning probes reveal different cell function within the immune system
5. Lab that probes genetic clues to disease is poised for major expansion
6. Nanoscale stealth probe slides into cell walls seamlessly, say Stanford engineers
7. Scientists develop the first model for investigating the origins of testicular cancer in humans
8. New imaging technique could help physicians ease the aftermath of breast cancer
9. Scientists develop designer protein, opening new door in cancer research
10. Oral contraceptive use associated with increased risk of breast cancer
11. Purdue-IU team uncovers potential prostate cancer marker
Post Your Comments:
(Date:10/12/2015)... ... October 12, 2015 , ... ... secured a new corporate headquarters, located at 485 Madison Avenue, New York, NY ... and increased emphasis on cloud-based technology. , “Care to Care is a dynamic ...
(Date:10/12/2015)... ... October 12, 2015 , ... In the first known ... individuals involved in nursing research spent as much as the equivalent of four 40-hour ... a single successful National Institutes of Health (NIH) grant application for funds to conduct ...
(Date:10/12/2015)... ... October 12, 2015 , ... CMS’s just-released 2016 Medicare ... partners to assess and act on, indicating which stars measures are causing plans the ... Part D health plans should focus their efforts and how CMS intends to modify ...
(Date:10/12/2015)... ... October 12, 2015 , ... T.E.N., a technology ... evening, October 8, at the 2015 ISE® Northeast Executive Forum and Awards ... , Michael Towers, VP, executive information security officer for Allergan, was selected as ...
(Date:10/12/2015)... ... October 12, 2015 , ... On Sunday, October 18, the Sierra Regional Spine ... in support of all Washoe County students. This is the first time the institute ... Sparks Marina outlet mall outside Reno, Nevada. , The family and youth-focused event features ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... ) ... "Personalized Medicine, Targeted Therapeutics and Companion Diagnostic ... Industry Trends, Technologies, Participants, and Environment" ... ) has announced the addition of ... Companion Diagnostic Market to 2019 - Strategic ...
(Date:10/12/2015)... St. Paul, Minn. , Oct. 12, 2015 /PRNewswire/ ... with it, a need to help integrate these devices ... global leader of ergonomic healthcare mounting and mobility solutions, ... Carts, its lightest cart yet, for a wide array ... StyleView S-Tablet Cart SV10 was developed exclusively for Microsoft ...
(Date:10/12/2015)... 12, 2015 ... grow at 7.2% CAGR, microscopy market growth ... focus on nanotechnology, technological advancements, and increasing ... available with ... --> Complete report on microscopy ...
Breaking Medicine Technology: