Navigation Links
Fluorescent probe for oral cancer
Date:8/4/2010

UC Davis researchers have developed a laser probe for the early detection of oral cancer. A trial with human subjects shows that the device could also be used during surgery to locate the edges of a tumor.

Approximately 43,000 people in the U.S. are diagnosed with tumors of the mouth, pharynx and larynx each year. The main risk factor is smoking, but a recent rise in cases has been linked to human papillomavirus. Most cases are not diagnosed until the cancer has reached an advanced stage.

"There's a lot out there about breast, prostate and brain cancer, but people are not so aware about oral cancer and its devastating consequences," said Laura Marcu, a professor of biomedical engineering at UC Davis. "People don't think to look for it, and there isn't any routine screening."

Marcu's laboratory collaborated with Dr. Gregory Farwell's group in the Department of Otolaryngology at the UC Davis Cancer Center to develop the fiber-optic probe.

The probe stimulates molecules in the patient's tissues with a laser. Some of these molecules naturally respond by re-emitting fluorescent light. The device rapidly detects and analyzes this light using a process called "time-resolved fluorescence spectroscopy" (TR-LIFS), which provides information about the types of molecules present.

During surgery, blood can distort the intensity of the fluorescence signal but not its duration. By using sensitive measurements of the change in fluorescence over time, surgeons can see the tumor margins even as they are cutting the tissue.

Based on encouraging results in animal tests, Marcu and Farwell's team recruited nine human volunteers from among patients who arrived at the UC Davis Medical Center for surgical therapy of the mouth, throat and larynx. They compared readings from spectroscopy with biopsy samples from the same locations and found that the probe could accurately diagnose the cancer in the surgical environment.

The probe is similar to one that Marcu has already developed for use with brain tumors. In clinical trials, surgeons have used her technology to delineate the margins of tumors during surgery.

Details of the human oral cancer study were published in the June issue of the journal Otolaryngology - Head and Neck Surgery. The pilot study in patients was supported in part by the Cancer Center and the Clinical and Translational Science Center at the UC Davis School of Medicine and the UC Davis Center for Biophotonics Science and Technology.


'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
University of California - Davis - Health System
Source:Eurekalert

Related medicine news :

1. Replacing hydrogen in fluorescent dyes improves detection ability, stability and shelf life
2. Fluorescent probes light up cancerous tumors
3. Study Probes Causes of Anger in Returning U.S. Soldiers
4. PET scanning probes reveal different cell function within the immune system
5. Lab that probes genetic clues to disease is poised for major expansion
6. Nanoscale stealth probe slides into cell walls seamlessly, say Stanford engineers
7. Scientists develop the first model for investigating the origins of testicular cancer in humans
8. New imaging technique could help physicians ease the aftermath of breast cancer
9. Scientists develop designer protein, opening new door in cancer research
10. Oral contraceptive use associated with increased risk of breast cancer
11. Purdue-IU team uncovers potential prostate cancer marker
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... California (PRWEB) , ... September 22, 2017 , ... ... the inaugural SABRE Safe Is Smart Scholarship Sweepstakes.,  , Molli C., a graduate ... an MS in Educational Leadership and Administration at St. Thomas University in Miami, ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... supplement produced by Native Remedies that helps promote pancreatic health and regulate ... individuals. However, some prescription-based approaches can have negative side effects, and with the ...
(Date:9/22/2017)... ... September 22, 2017 , ... “Fruit of the Spirit: ... while exploring nature that God has created. “Fruit of the Spirit: “Love”” is the ... now a devoted wife and mother of five. Halimah is an avid writer, her ...
(Date:9/22/2017)... ... 22, 2017 , ... Global Lyme Alliance (GLA), the leading ... awareness, today announced the appointment of Timothy J. Sellati, Ph.D. as its Chief ... than 20 years of research experience with Lyme and other tick-borne diseases. He ...
(Date:9/21/2017)... ... September 21, 2017 , ... SABRE is raising awareness ... September 11 to the end of November. , The Chicago, Illinois, based self-defense brand ... and teach them about the ease of taking their personal safety into their own ...
Breaking Medicine News(10 mins):
(Date:9/1/2017)... , Sept. 1, 2017 Michael ... Solutions, Inc , highlights opportunities for growth in his ... report that Marlin Equity is seeking a buyer for ... annual award-winning 22-year-old healthcare solutions Value Added Reseller and ... "As the healthcare market ...
(Date:8/31/2017)... Aug. 31, 2017 PM360,s annual Innovations ... to the latest innovations happening across the industry. Established ... to focus on providing a comprehensive look at the ... covers the most innovative companies, startups, divisions, products, services, ... "Everyone in this industry wants to ...
(Date:8/28/2017)... CHICAGO , Aug. 28, 2017 Hill-Rom Holdings, ... Healthcare Conference on Monday, September 11, 2017, in ... and chief executive officer, is scheduled to present at 11:05 ... can be accessed at http://ir.hill-rom.com/events.cfm . A recorded replay ... live event through December 10, 2017. ...
Breaking Medicine Technology: