Navigation Links
'Fluorescent' Retinal Cells Warn of Eye Disease
Date:2/12/2008

Device that measures metabolic stress could help doctors catch trouble early

MONDAY, Feb. 11 (HealthDay News) -- That twinkle in your eye could be an early sign of eye disease if it is seen using a new imaging device developed by scientists at the University of Michigan.

The device detects certain proteins that become fluorescent during the metabolic stress that typically happens at the onset of eye diseases, according to findings published in the February issue of the Archives of Ophthalmology. This flavoprotein autofluorescence (FA) occurs when retinal cells begin to die.

"Autofluorescence occurs when retinal cells begin to die, often the first event in diseases like glaucoma and diabetic retinopathy," study co-author Howard Petty, a biophysicist and expert in imaging with the university's Kellogg Eye Center, said in a prepared statement. "Cell death can be observed microscopically, but not as yet through any current imaging methods. We believe this study is a big step forward, toward creating a diagnostic tool that can characterize disease long before symptoms or visible signs appear."

Many severe eye diseases do not show early symptoms before they begin to diminish vision. Using this device to test a patient is noninvasive and takes less than six minutes, according to the study.

In the study, Petty and fellow researcher Victor M. Elner used the instrument to measure the degree to which a subtle visual condition affected six women. The women had been recently diagnosed with pseudotumor cerebri (PTC), a condition that mimics a brain tumor and often causes increased pressure on the optic nerve that can lead to vision loss.

Because each woman's disease was in a very early stage, the researchers could evaluate how accurately the instrument would detect vision loss as compared to several standard tests used to evaluate vision. In each case, their imaging instrument provided results that were equal to and often superior to the standard tests.

The researchers also found that FA data more accurately described the degree of disease in each patient's eye as compared to the standard vision tests. The patients with PTC had FA values that averaged 60 percent greater in the eye that was more severely affected, the study said. By contrast, an age-matched control group had no significant difference in FA values between their healthy eyes.

"Early treatment for eye disease is so important, and this study suggests that FA activity is a very good indicator of eye disease," Elner, an ophthalmologist and a pathologist, said in a prepared statement. "Cardiologists have long used blood pressure testing to head off heart disease. We believe that FA testing will likewise be a helpful diagnostic tool for eye doctors looking to prevent blindness."

Elner and Petty have patented the device and are investigating its use as a screening device in diabetes and major eye diseases.

More information

The National Eye Institute has more about eye diseases and disorders.



-- Kevin McKeever



SOURCE: University of Michigan Health System, news release, Feb. 11, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Twinkle after effect can help retinal patients detect vision loss quickly and cheaply
2. Twinkle After-Effect Can Help Retinal Patients Detect Vision Loss Quickly and Cheaply and Prevent Further Loss
3. Transporters may help delay diabetes-related retinal damage
4. Digital Healthcare Announces MacGregor Medical Center San Antonio to Utilize Retasure for Retinal Imaging Assessment
5. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
6. Brain cells work differently than previously thought
7. Embryonic Stem Cells Repair Human Heart
8. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
9. Circulating fats kill transplanted pancreas cells, study shows
10. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
11. Melanoma drug revs immune cells but cancer cells ignore it
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Fluorescent' Retinal Cells Warn of Eye Disease
(Date:6/27/2016)... KS (PRWEB) , ... June 27, 2016 , ... TopConsumerReviews.com ... retailers of Eyeglasses . , Millions of individuals in the United States and ... have become a way to both correct vision and make a fashion statement. Even ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping ... fitness app. The fitness app plans to fix the two major problems leading the fitness ... size fits all type program , They don’t eliminate all the reasons people ...
(Date:6/25/2016)... ... 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily ... of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures ... . Simply select a ProHand generator and drag it above media or text in ...
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of ... too high can result in disappointment, perhaps even self-loathing. However, those who set the ... Research from PsychTests.com reveals that behind the tendency to set low expectations ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, Inc., ... development and manufacturing of collagen and mineral based ... today that Bill Messer has joined ... to further leverage the growing portfolio of oral ... Bill joins the Collagen Matrix executive ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
Breaking Medicine Technology: