Navigation Links
'Fluorescent' Retinal Cells Warn of Eye Disease
Date:2/12/2008

Device that measures metabolic stress could help doctors catch trouble early

MONDAY, Feb. 11 (HealthDay News) -- That twinkle in your eye could be an early sign of eye disease if it is seen using a new imaging device developed by scientists at the University of Michigan.

The device detects certain proteins that become fluorescent during the metabolic stress that typically happens at the onset of eye diseases, according to findings published in the February issue of the Archives of Ophthalmology. This flavoprotein autofluorescence (FA) occurs when retinal cells begin to die.

"Autofluorescence occurs when retinal cells begin to die, often the first event in diseases like glaucoma and diabetic retinopathy," study co-author Howard Petty, a biophysicist and expert in imaging with the university's Kellogg Eye Center, said in a prepared statement. "Cell death can be observed microscopically, but not as yet through any current imaging methods. We believe this study is a big step forward, toward creating a diagnostic tool that can characterize disease long before symptoms or visible signs appear."

Many severe eye diseases do not show early symptoms before they begin to diminish vision. Using this device to test a patient is noninvasive and takes less than six minutes, according to the study.

In the study, Petty and fellow researcher Victor M. Elner used the instrument to measure the degree to which a subtle visual condition affected six women. The women had been recently diagnosed with pseudotumor cerebri (PTC), a condition that mimics a brain tumor and often causes increased pressure on the optic nerve that can lead to vision loss.

Because each woman's disease was in a very early stage, the researchers could evaluate how accurately the instrument would detect vision loss as compared to several standard tests used to evaluate vision. In each case, their imaging instrument provided results that were equal to and often superior to the standard tests.

The researchers also found that FA data more accurately described the degree of disease in each patient's eye as compared to the standard vision tests. The patients with PTC had FA values that averaged 60 percent greater in the eye that was more severely affected, the study said. By contrast, an age-matched control group had no significant difference in FA values between their healthy eyes.

"Early treatment for eye disease is so important, and this study suggests that FA activity is a very good indicator of eye disease," Elner, an ophthalmologist and a pathologist, said in a prepared statement. "Cardiologists have long used blood pressure testing to head off heart disease. We believe that FA testing will likewise be a helpful diagnostic tool for eye doctors looking to prevent blindness."

Elner and Petty have patented the device and are investigating its use as a screening device in diabetes and major eye diseases.

More information

The National Eye Institute has more about eye diseases and disorders.



-- Kevin McKeever



SOURCE: University of Michigan Health System, news release, Feb. 11, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Twinkle after effect can help retinal patients detect vision loss quickly and cheaply
2. Twinkle After-Effect Can Help Retinal Patients Detect Vision Loss Quickly and Cheaply and Prevent Further Loss
3. Transporters may help delay diabetes-related retinal damage
4. Digital Healthcare Announces MacGregor Medical Center San Antonio to Utilize Retasure for Retinal Imaging Assessment
5. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
6. Brain cells work differently than previously thought
7. Embryonic Stem Cells Repair Human Heart
8. Embryonic Human Stem Cells May Help Repair Heart Muscle, Lab Study Shows
9. Circulating fats kill transplanted pancreas cells, study shows
10. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
11. Melanoma drug revs immune cells but cancer cells ignore it
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
'Fluorescent' Retinal Cells Warn of Eye Disease
(Date:2/9/2016)... ... February 09, 2016 , ... IsoComforter, ... the introduction of the newly designed, innovative shoulder wrap. The newly designed ... coverage for the injured arm and shoulder to promote faster healing. It is ...
(Date:2/9/2016)... ... February 09, 2016 , ... Sir ... company , is proud to announce that many of their franchises have received ... service. The hard surface restoration franchises received customer recognition through positive reviews and ...
(Date:2/9/2016)... ... February 09, 2016 , ... ... officially been won. A team from 21st Century Medicine (21CM) ( http://www.21cm.com/ ... preserve the delicate neural circuits of an intact rabbit brain for extremely long-term ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... authorization with BASF Human Nutrition into the Food & Beverage and ... has been BASF’s channel partner throughout Canada and USA geographies east of the ...
(Date:2/8/2016)... ... February 08, 2016 , ... The Valentine’s Season is famous for gift giving with flowers, chocolates ... they are loved. This year, for more than 5.6 million Americans suffering with Alzheimer’s, ... be enough to remind them of the lives they’ve led and the people they’ve touched. ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... 9, 2016   AllCare Plus Pharmacy announced ... Seal of Approval ® for Home Care ... standards. The Gold Seal of Approval ® is ... to providing safe and effective care.  ... underwent a rigorous on-site survey in January 2016. The ...
(Date:2/9/2016)... Feb. 9, 2016 The new report "Global Diagnostic Ultrasound ... & Consulting group reveals that global diagnostic ultrasound devices market was ... to US$ 7,466.3 million by 2019 at a CAGR of 6.8% ... global ultrasound market has been analyzed for six geographies of ... Asia-Pacific , Latin America , ...
(Date:2/9/2016)... , Feb. 9, 2016 The global ... 2014, and it is expected to grow with a ... the glass prefilled syringes segment dominated the global prefilled ... --> --> The global market ... rate, due to increasing geriatric population, increasing demand for ...
Breaking Medicine Technology: