Navigation Links
Flu virus foiled again
Date:2/26/2009

WHAT: Researchers at The Scripps Research Institute in La Jolla, California, supported in part by the National Institutes of Health, have identified a common Achilles' heel in a wide range of seasonal and pandemic influenza A viruses. The study found an infection-fighting protein, or human antibody, that neutralizes various influenza A virus subtypes by attaching to these viruses in the same place. This common attachment site provides a constant region of the flu virus for scientists to target in an effort to develop a so-called universal flu vaccine. Such a vaccine would overcome the annual struggle to make the seasonal flu vaccine match next year's circulating flu strains and might help blunt emerging pandemic influenza viruses as well.

The study provides data about the antibody attachment site that are similar to the findings of another research group, reported on February 22, 2009 (see http://www3.niaid.nih.gov/news/newsreleases/2009/flu_mab.htm). Taken together, these studies provide a blueprint for efforts to develop new antiviral drugs as well as a potential universal influenza vaccine.

The Scripps research team, led by Ian A. Wilson, Ph.D., in collaboration with researchers at the biopharmaceutical company Crucell Holland (The Netherlands), discovered the potent antibody during a systematic examination of blood samples taken from healthy individuals who previously had been vaccinated with the ordinary seasonal flu vaccine. Using sophisticated screening technologies, the scientific team isolated antibodies that recognize flu viruses to which the average person has never been exposed, such as H5N1 avian flu viruses. Through this process, the scientists found one antibody called CR6261 that had broad neutralizing capabilities. Subsequently, they found several antibodies similar to CR6261 in other donors as well. With the help of a robotic crystallization laboratory, the Scripps team quickly determined the detailed three-dimensional structures of this antibody when bound to the H1 virus that caused the 1918 pandemic flu as well as to an H5 virus with pandemic potential. CR6261 bound to a relatively hidden part in the stem below the mushroom-shaped head of the hemagglutinin protein, one of two major surface proteins found on the flu virus.


'/>"/>

Contact: Laurie K. Doepel
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. The Journal of Nutrition Publishes Study Indicating that AHCC(R) Provides Immune Support against West Nile Virus
2. Team learns how cellular protein detects viruses and sparks immune response
3. Human papillomavirus lesion identified at the dentist
4. Scientists uncover secrets of potential bioterror virus
5. Complete Genomes of All Known Human Rhinoviruses are Published
6. Genes Help Cancer-Linked Viruses Elude Immune System
7. eFoodSafety Enters Research Agreement with University of Minnesota to Test New Food-Grade Antiviral for Swine Influenza Virus
8. Penn study identifies how ebola virus avoids the immune system
9. Oklahoma State University researchers make breakthrough against poxviruses
10. Drug Impedes Bodys Deadly Reaction to Flu Virus
11. Common Asthma Treatments Dont Work for Virus-Induced Wheeze
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2017)... ... ... In a continuous effort to raise awareness of autism and common toxins ... in natural and organic latex mattresses, has announced that they will donate $1 to ... their recent viral Facebook video receives, up to $10,000.00. , The luxury ...
(Date:5/19/2017)... ... May 19, 2017 , ... DMG Productions ... episode of Innovations with Ed Begley, Jr., airing fourth quarter 2017 on FOX ... a clean, organic dietary supplement made from naturally occurring ingredients. Innovations will enlighten ...
(Date:5/19/2017)... Springfield, Vermont (PRWEB) , ... May 19, 2017 , ... ... on its company blog. Titled " Ten Good Reasons To Hire An Experienced Personal ... decisions to make following an accident or injury. As the article says. if someone ...
(Date:5/19/2017)... Atlantic Beach, FL (PRWEB) , ... May 19, ... ... that provides asset protection services and retirement planning assistance to families and business ... National Multiple Sclerosis Society to advocate for MS sufferers and their families. , ...
(Date:5/19/2017)... ... May 19, 2017 , ... SyncDog, Inc. , ... session at the 7th Annual ET6 Exchange (formerly M6 xChange), the ... transformation conference whose expressed purpose is to connect mobile technology end users with ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)...  Semler Scientific, Inc. (OTCQB: SMLR), an emerging ... the clinical effectiveness and efficiency of healthcare providers, ... ended March 31, 2017. "We ... identify when preventive care options are appropriate, which ... attacks or strokes occur," said Doug Murphy-Chutorian ...
(Date:5/6/2017)... , May 5, 2017  May is Stroke ... one of the most important methods to prevent a ... the Centers for Disease Control and Prevention, undetected and ... 1 Omron, the global leader in personal heart ... the elimination of heart attack and stroke and is ...
(Date:5/4/2017)... SAN DIEGO , May 4, 2017 /PRNewswire/ ... is demonstrating its wireless, handheld ultrasound scanners this ... Gynecologists Annual Scientific Meeting (ACOG) in ... 2017. "Clarius is the perfect ... fetal growth and heart rate, and evaluate pregnancy-related ...
Breaking Medicine Technology: