Navigation Links
Flu Shot May Be Less Effective in Those With Lupus
Date:7/30/2009

Certain medications could explain diminished protection, researchers say

THURSDAY, July 30 (HealthDay News) -- The two prime means by which the seasonal influenza vaccine activates the immune system against the virus appear to be diminished in people with lupus, a new study finds.

According to Dutch researchers led by Albert Holvast, of the University of Groningen, the human immune system goes on alert against the seasonal flu virus after vaccination in two ways. First, it generates antibodies specifically reacting to the flu virus, and secondly, it primes certain immune T-cells to respond to the flu bug.

Prior work had already shown that the antibody-mediated vaccine response was dimmed in lupus patients, and the new study, involving 54 patients with lupus and 54 healthy controls, replicated those findings.

But the study, published in the August issue of Arthritis & Rheumatism, also found that the activity of those T-cells key to immunization were diminished in lupus patients who received the flu shot vs. immunized healthy controls. This dip in cell-mediated responses was linked to the use of the medications prednisone and/or azathioprine, the researchers added.

Flu vaccination did not impact lupus disease activity, the team said.

"Clinicians should be aware that this combined defect might increase the morbidity and mortality due to influenza virus infection, in particular in patients receiving prednisone and/or azathioprine," the researchers advised. They also called for more investigation into whether alternate flu vaccination strategies might offer better protection to people with lupus.

More information

There's more on lupus at the Lupus Foundation of America.



-- E.J. Mundell



SOURCE: Arthritis & Rheumatism, news release, July 30, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Hormonal Therapies Offer Effective Solutions for Many Adult Women With Acne
2. Urine Test for Chlamydia Shown Effective in Men
3. CareFusion Form 10 Registration Statement Declared Effective
4. Paper Highlights Antimicrobial Effectiveness of Medical-Grade Honey in Topical Wound Care
5. Sen. Tom Daschle, Rep. Jason Altmire, Healthcare Experts Tout Homecare as Cost-Effective Solution in the Healthcare Reform Process
6. President Obamas Visit to Cleveland Clinic Provides Look at High-Quality, Cost-Effective Healthcare Delivery Model
7. Top Hepatitis C Treatments Equally Effective
8. NCCN Will Convene National Policy Summit on Comparative Effectiveness in Cancer Care
9. Earlier HIV antiviral treatment can be cost effective in areas of limited resources
10. Congress Must Recognize Homecare as Cost-Effective Part of Health Care Reform
11. Flexi-Seal(R) Fecal Management System Receives 2008 Critical Care Nurse Advertising Effectiveness Award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Flu Shot May Be Less Effective in Those With Lupus
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
Breaking Medicine Technology: