Navigation Links
Flu Shot May Be Less Effective in Those With Lupus

Certain medications could explain diminished protection, researchers say

THURSDAY, July 30 (HealthDay News) -- The two prime means by which the seasonal influenza vaccine activates the immune system against the virus appear to be diminished in people with lupus, a new study finds.

According to Dutch researchers led by Albert Holvast, of the University of Groningen, the human immune system goes on alert against the seasonal flu virus after vaccination in two ways. First, it generates antibodies specifically reacting to the flu virus, and secondly, it primes certain immune T-cells to respond to the flu bug.

Prior work had already shown that the antibody-mediated vaccine response was dimmed in lupus patients, and the new study, involving 54 patients with lupus and 54 healthy controls, replicated those findings.

But the study, published in the August issue of Arthritis & Rheumatism, also found that the activity of those T-cells key to immunization were diminished in lupus patients who received the flu shot vs. immunized healthy controls. This dip in cell-mediated responses was linked to the use of the medications prednisone and/or azathioprine, the researchers added.

Flu vaccination did not impact lupus disease activity, the team said.

"Clinicians should be aware that this combined defect might increase the morbidity and mortality due to influenza virus infection, in particular in patients receiving prednisone and/or azathioprine," the researchers advised. They also called for more investigation into whether alternate flu vaccination strategies might offer better protection to people with lupus.

More information

There's more on lupus at the Lupus Foundation of America.

-- E.J. Mundell

SOURCE: Arthritis & Rheumatism, news release, July 30, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Hormonal Therapies Offer Effective Solutions for Many Adult Women With Acne
2. Urine Test for Chlamydia Shown Effective in Men
3. CareFusion Form 10 Registration Statement Declared Effective
4. Paper Highlights Antimicrobial Effectiveness of Medical-Grade Honey in Topical Wound Care
5. Sen. Tom Daschle, Rep. Jason Altmire, Healthcare Experts Tout Homecare as Cost-Effective Solution in the Healthcare Reform Process
6. President Obamas Visit to Cleveland Clinic Provides Look at High-Quality, Cost-Effective Healthcare Delivery Model
7. Top Hepatitis C Treatments Equally Effective
8. NCCN Will Convene National Policy Summit on Comparative Effectiveness in Cancer Care
9. Earlier HIV antiviral treatment can be cost effective in areas of limited resources
10. Congress Must Recognize Homecare as Cost-Effective Part of Health Care Reform
11. Flexi-Seal(R) Fecal Management System Receives 2008 Critical Care Nurse Advertising Effectiveness Award
Post Your Comments:
Related Image:
Flu Shot May Be Less Effective in Those With Lupus
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. ... articles published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... The Grove Investment Group (TGIG), has initiated cultivation and processing operations at its ... Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete system ...
(Date:6/24/2016)... ... , ... National recruitment firm Slone Partners is pleased to announce ... experience, as Vice President of North American Capital Sales at HTG Molecular . ... sales team in the commercialization of the HTG EdgeSeq system and associated reagents in ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... MEMS Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data ... analysis. Assessment of major trends with potential impact on the ... analysis of market segmentation which comprises of sub markets, regional ...
(Date:6/23/2016)... 23, 2016 Bracket , a leading clinical ... generation clinical outcomes platform, Bracket eCOA (SM) 6.0, at ... 26 – 30, 2016 in Philadelphia , ... Outcome Assessment product of its kind to fully integrate with ... Bracket eCOA 6.0 is a flexible platform for electronic clinical ...
(Date:6/23/2016)... BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia ... the company,s second affiliate in Latin America . ... ... Farma Colombia ... ...
Breaking Medicine Technology: