Navigation Links
Flip of a single molecular switch makes an old brain young
Date:3/6/2013

The flip of a single molecular switch helps create the mature neuronal connections that allow the brain to bridge the gap between adolescent impressionability and adult stability. Now Yale School of Medicine researchers have reversed the process, recreating a youthful brain that facilitated both learning and healing in the adult mouse.

Scientists have long known that the young and old brains are very different. Adolescent brains are more malleable or plastic, which allows them to learn languages more quickly than adults and speeds recovery from brain injuries. The comparative rigidity of the adult brain results in part from the function of a single gene that slows the rapid change in synaptic connections between neurons.

By monitoring the synapses in living mice over weeks and months, Yale researchers have identified the key genetic switch for brain maturation a study released March 6 in the journal Neuron. The Nogo Receptor 1 gene is required to suppress high levels of plasticity in the adolescent brain and create the relatively quiescent levels of plasticity in adulthood. In mice without this gene, juvenile levels of brain plasticity persist throughout adulthood. When researchers blocked the function of this gene in old mice, they reset the old brain to adolescent levels of plasticity.

"These are the molecules the brain needs for the transition from adolescence to adulthood," said Stephen Strittmatter. Vincent Coates Professor of Neurology, Professor of Neurobiology and senior author of the paper. "It suggests we can turn back the clock in the adult brain and recover from trauma the way kids recover."

Rehabilitation after brain injuries like strokes requires that patients re-learn tasks such as moving a hand. Researchers found that adult mice lacking Nogo Receptor recovered from injury as quickly as adolescent mice and mastered new, complex motor tasks more quickly than adults with the receptor.

"This raises the potential that manipulating Nogo Receptor in humans might accelerate and magnify rehabilitation after brain injuries like strokes," said Feras Akbik, Yale doctoral student who is first author of the study.

Researchers also showed that Nogo Receptor slows loss of memories. Mice without Nogo receptor lost stressful memories more quickly, suggesting that manipulating the receptor could help treat post-traumatic stress disorder.

"We know a lot about the early development of the brain," Strittmatter said, "But we know amazingly little about what happens in the brain during late adolescence."


'/>"/>

Contact: Bill Hathaway
william.hathaway@yale.edu
203-432-1322
Yale University
Source:Eurekalert  

Related medicine news :

1. First single gene mutation shown to result in type 1 diabetes
2. Valentines Day a Show of Wealth for Single Men?
3. Project to capture and interrogate single cancer cells wins innovator award
4. SingleSource Background Company Shares Five Hiring Mistakes to Avoid in 2013
5. Ordinary heart cells become biological pacemakers with injection of a single gene
6. A Single Pill for Heart Disease Prevention? from the December 2012 Harvard Women's Health Watch
7. GiveForward.com Helps Launch Online Campaign to Help Sick Single Mom in Need
8. Rilpivirine for HIV: Added benefit for single agent proven
9. How do cells tell time? Scientists develop single-cell imaging to watch the cell clock
10. Cervical cancer and pre-cancer cervical growths require single HPV protein
11. Single gene cause of insulin sensitivity may offer insight for treating diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Flip of a single molecular switch makes an old brain young
(Date:9/25/2017)... VA (PRWEB) , ... September 25, 2017 , ... ... and Response Preconference Workshop, **Presented by FDAnews**, Nov. 1-3, 2017 – Bethesda, MD, ... drugmaker passed with flying colors. And then, on the tenth inspection it failed. ...
(Date:9/24/2017)... (PRWEB) , ... September 25, 2017 , ... Bhowanie Benimadhu’s ... iUniverse) explores the fundamental questions of life and seeks answers in both Eastern and ... , “The searching for God is in the mind of humankind for the past ...
(Date:9/24/2017)... , ... September 23, 2017 , ... Throughout the United ... harm. , Every day, physicians, nurses and other providers work to give the ... innovative industry processes. , But U.S. Senators today are threatening to tie our ...
(Date:9/24/2017)... ... ... Messiah 8 with the 3rd Anti Christ”: a forceful and dynamic narrative that ... Anti Christ” is the creation of published author, Albert Velazquez. , “It ... Velazquez states, “I always come to the same conclusion: God loves working in mysterious ...
(Date:9/24/2017)... ... ... “The Gospel Truth Of The Bible: The Other Sheep”: the ceremonial laws of Moses and ... Sheep” is the creation of published author, Maurice Caines. Maurice Caines resides in the ... been a member of the Seventh-day Adventist Church for many years. He was previously ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... , Sept. 7, 2017  For nearly two decades, New Life Agency ... Assisted Reproduction Insurance industry. Today, New Life Agency announces a powerful three-way ... ... ... http://pharmacarecard.com/ (PRNewsfoto/PharmaCareCard) ...
(Date:9/7/2017)... Sept. 7, 2017 NuvoAir (formerly called ... announced today a partnership with Novartis Pharma AG to distribute ... position as the leading mobile spirometry platform and Novartis, commitment ... ... ...
(Date:9/7/2017)... 7, 2017   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade cell and tissue hypothermic storage ... Mike Rice , President and CEO, will be presenting at ... Rodman & Renshaw 19 th Annual Global Investment Conference ... p.m. Pacific time). The conference is being held at the ...
Breaking Medicine Technology: