Navigation Links
Flexible sigmoidoscopy screening reduces colorectal cancer incidence, rate of death
Date:8/12/2014

Among about 100,000 study participants, screening with flexible sigmoidoscopy resulted in a reduced incidence and rate of death of colorectal cancer, compared to no screening, according to a study in the August 13 issue of JAMA.

Colorectal cancer is the third most commonly occurring cancer worldwide. Most colorectal cancer cases develop from adenomas (benign tumors). Removal of adenomas by colonoscopy or flexible sigmoidoscopy (a thin flexible lighted tube used for inspection of the inside of the rectum and lower part of the colon) has been endorsed as a primary prevention tool for colorectal cancer, according to background information in the article.

yvind Holme, M.D., of the Sorlandet Hospital Kristiansand, Kristiansand, Norway and colleagues randomly assigned study participants in Norway to receive once-only flexible sigmoidoscopy (n=10, 283); a combination of once-only flexible sigmoidoscopy and fecal occult blood testing (FOBT; n=10,289), or no intervention (control group; n=78,220). Screening was performed in 1999-2000 (55-64-year age group) and in 2001 (50-54-year age group), with follow-up ending December 2011. Participants with positive screening test results were offered colonoscopy.

After a median of 11 years, 71 participants died of colorectal cancer in the screening groups vs 330 in the control group. Colorectal cancer was diagnosed in 253 participants in the screening groups vs 1,086 in the control group. Analysis of the data indicated that compared to no screening, flexible sigmoidoscopy screening reduced colorectal cancer incidence by 20 percent (absolute difference, 28.4 cases/100,000 person years) and colorectal cancer mortality by 27 percent (absolute difference, 11.7 deaths/100,000 person years). There was no significant difference in these outcomes between the flexible sigmoidoscopy only vs the flexible sigmoidoscopy and FOBT screening groups.

Younger participants 50 to 54 years of age seemed to benefit at least as much from the screening interventions as older participants ages 55 to 64 years.

(doi:10.1001/jama.2014.8266; Available pre-embargo to the media at http://media.jamanetwork.com)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Flexible Sigmoidoscopy for Colorectal Cancer Screening More Evidence, Persistent Ironies

In an accompanying editorial, Allan S. Brett, M.D., of the University of South Carolina School of Medicine, Columbia, S.C., writes that while there may be debate over the use of flexible sigmoidoscopy or colonoscopy for colorectal cancer screening, another screening technique, stool DNA testing, might render this debate moot in the not-toodistant future.

"A large, recently published study examined the performance of a multitarget stool test that identifies several DNA abnormalities associated with colorectal cancer or precancerous adenomas. With colonoscopy as the reference standard, the sensitivity of the stool DNA test was 92 percent for detecting cancer and 42 percent for detecting advanced precancerous lesions; specificity was 90 percent. Notably, the stool DNA test was much more sensitive than a separate fecal immunochemical test for hemoglobin performed for each participant. Repeated at some defined interval, stool DNA testing has potential to reduce colorectal cancer mortality substantially while sharply reducing the number of routine colonoscopies. For now, however, the muddled landscape of colorectal cancer screening in the United States continues, and the place of flexible sigmoidoscopy among screening tools remains unsettled."

(doi:10.1001/jama.2014.8613; Available pre-embargo to the media at http://media.jamanetwork.com)

Editor's Note: The author has completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.


'/>"/>

Contact: Øyvind Holme, M.D.
oyvind.holme@sshf.no
The JAMA Network Journals
Source:Eurekalert

Related medicine news :

1. HR Strategies Holds Flexible Spending Account and Voluntary Benefit Open Enrollment
2. Research to make UK manufacturing flexible and adaptable
3. Lack of awareness limits use of flexible career policies
4. Spectrum Surgical Releases Flexible Bone Reamer Cleaning Brushes
5. Flexible AC Transmission System (FACTS) Market (Compensation, Component, Application, Industry Vertical) Worth $1,386.01 Million by 2018 - New Report by MarketsandMarkets
6. Flexible Applications Based on Printed Electronics Technologies
7. Aging erodes genetic control, but thats flexible
8. Flexible AC Transmission System (FACTS) Market (Compensation, Component, Application, Industry Vertical) Worth $1,386.01 Million by 2018 - New Report by MarketsandMarkets
9. Bioplastic and Flexible Packaging Market: Containers in US Analyzed and Forecast in New Research Reports at ReportsnReports.com
10. 4DSP Introduces a Compact Platform for UAVs with Embedded Processing and Flexible IO
11. NIH study finds sigmoidoscopy reduces colorectal cancer rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... CA (PRWEB) , ... January ... ... provider of translation and localization services for life science companies, has achieved ... inspection organization, TÜV SÜD America. ISO 17100 is the globally recognized standard ...
(Date:1/23/2017)... , ... January 23, 2017 , ... ... is taught by healthcare management and evaluation leaders with decades of experience who ... pay-for-value in the United States healthcare system, there is a renewed demand for ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... applications. However, choosing the right method is paramount to success. Selecting an inappropriate ... in situations where multiple persons use the same equipment. Rare or expensive substances ...
(Date:1/23/2017)... (PRWEB) , ... January 23, 2017 , ... ... providing high-quality general gynecological care and gynecological services for women of ... personalized care for a wide variety of reproductive services from routine health screenings ...
(Date:1/23/2017)... ... , ... “Some Infallible Characteristics of Christ”: a fascinating and entrancing novel ... the creation of published author, Rev. Dr. Robert W. Thomas, the third of seven ... for over nineteen, a pastor for over fifteen years. He is a graduate of ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... , Jan. 23, 2017 Endo International ... Trade Commission (FTC) today filed a joint motion in ... California seeking the entry of ... Order resolves all disputes between the FTC and Endo ... in connection with its Opana® ER and Lidoderm® products.  ...
(Date:1/23/2017)... Research and Markets has announced the addition of the ... their offering. ... The interventional radiology products market is expected to reach USD 8.02 ... CAGR of 4.8%. This market is segmented based on type, procedure, ... of this market are rising incidence of chronic diseases, rising geriatric ...
(Date:1/23/2017)... , Jan. 23, 2017 7D ... 510(k) clearance from the U.S. Food and Drug ... Health Canada enabling the North American commercial launch ... system for spine surgery, the 7D Surgical System.  ... cutting-edge 3D optical technologies and machine vision algorithms ...
Breaking Medicine Technology: