Navigation Links
First test of pluripotent stem cell therapy in monkeys is a success
Date:5/15/2014

Researchers have shown for the first time in an animal that is more closely related to humans that it is possible to make new bone from stem-cell-like induced pluripotent stem cells (iPSCs) made from an individual animal's own skin cells. The study in monkeys reported in the Cell Press journal Cell Reports on May 15th also shows that there is some risk that those iPSCs could seed tumors, but that unfortunate outcome appears to be less likely than studies in immune-compromised mice would suggest.

"We have been able to design an animal model for testing of pluripotent stem cell therapies using the rhesus macaque, a small monkey that is readily available and has been validated as being closely related physiologically to humans," said Cynthia Dunbar of the National Heart, Lung, and Blood Institute. "We have used this model to demonstrate that tumor formation of a type called a 'teratoma' from undifferentiated autologous iPSCs does occur; however, tumor formation is very slow and requires large numbers of iPSCs given under very hospitable conditions. We have also shown that new bone can be produced from autologous iPSCs, as a model for their possible clinical application."

Autologous refers to the fact that the iPSCs capable of producing any tissue typein this case bonewere derived from the very individual that later received them. That means that use of these cells in tissue repair would not require long-term or possibly toxic immune suppression drugs to prevent rejection.

The researchers first used a standard recipe to reprogram skin cells taken from rhesus macaques. They then coaxed those cells to form first pluripotent stem cells and then cells that have the potential to act more specifically as bone progenitors. Those progenitor cells were then seeded onto ceramic scaffolds that are already in use by reconstructive surgeons attempting to fill in or rebuild bone. And, it worked; the monkeys grew new bone.

Importantly, the researchers report that no teratoma structures developed in monkeys that had received the bone "stem cells." In other experiments, undifferentiated iPSCs did form teratomas in a dose-dependent manner.

The researchers say that therapies based on this approach could be particularly beneficial for people with large congenital bone defects or other traumatic injuries. Although bone replacement is an unlikely "first in human" use for stem cell therapies given that the condition it treats is not life threatening, the findings in a primate are an essential step on the path toward regenerative clinical medicine.

"A large animal preclinical model for the development of pluripotent or other high-risk/high-reward generative cell therapies is absolutely required to address issues of tissue integration or homing, risk of tumor formation, and immunogenicity," Dunbar said. "The testing of human-derived cells in vitro or in profoundly immunodeficient mice simply cannot model these crucial preclinical safety and efficiency issues."

The NIH team is now working with collaborators on differentiation of the macaque iPSCs into liver, heart, and white blood cells for eventual clinical trials in hepatitis C, heart failure, and chronic granulomatous disease, respectively.


'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Related medicine news :

1. Getting chemo first may help in rectal cancer
2. Glutamate imaging better than MR spectroscopy in first 3 hours after ischemic stroke
3. Treat homelessness first, everything else later: Study
4. First size-based chromatography technique for the study of livi
5. FDA approves first targeted drug for advanced stomach cancer
6. Pitt, UPMC to serve as the first US host of global health conference
7. First genetic link discovered to difficult-to-diagnose breast cancer sub-type
8. Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum
9. UCL and Max Planck Society invest €5m to open world first computational psychiatry center
10. NUS researchers developed worlds first fluorescent sensor to detect date rape drug
11. Sound trumps meaning in first language learning
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2016)... ... November 30, 2016 , ... "I hate when the mixture ... brushing my teeth," said an inventor from Bridgewater, N.J. "I thought that there had ... handy device." , He developed the patent-pending DEFLECTOR to prevent saliva and toothpaste from ...
(Date:11/30/2016)... FL (PRWEB) , ... November 30, 2016 , ... ... disorder and mental health treatment has announced the opening of a new eating ... partial hospitalization and intensive outpatient treatment for adults and adolescents, both males and ...
(Date:11/30/2016)... , ... November 30, 2016 , ... ... injured workers have been a focus of public policymakers and system stakeholders in ... Institute (WCRI) released its Medical Price Index for Workers’ Compensation, Eighth Edition ...
(Date:11/30/2016)... ... November 30, 2016 , ... ... clinical research community that the FDA Binding Guidance goes into effect next month. ... formats listed in the FDA Data Standards Catalog. The current FDA Data Standards ...
(Date:11/30/2016)... ... 2016 , ... U.S. Security Associates (USA) announced the acquisition ... Richmond, Virginia. The acquisition further strengthens USA’s capabilities within the expanding healthcare ... prides itself on 100% client-retention to the healthcare industry. In addition, ODS has ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... YORK , December 2, 2016 ... the trading session in red, while the Dow Jones Industrial ... at the close of US markets, which prompted Stock-callers this ... stocks: NuVasive Inc. (NASDAQ: NUVA ), Smith & ... (NASDAQ: NXTM ), and Cesca Therapeutics Inc. (NASDAQ: ...
(Date:12/2/2016)... LONDON , Dec. 1, 2016 Around ... every country, region and each habitable land present over ... haunt every individual once in a life time this ... proper care available until now. Given the steady increase ... mortality, together with the spiraling healthcare costs of treatment, ...
(Date:11/30/2016)... Research and Markets has announced the addition ... - MedCore" report to their offering. ... , , The cerebrospinal fluid ... healthy individuals, it is circulated though the brain and its ventricles, the ... of CSF surrounding the brain changes significantly. As ...
Breaking Medicine Technology: