Navigation Links
First targeted nanomedicine to enter human clinical studies
Date:4/4/2012

BOSTON, MAA team of scientists, engineers and physicians from Brigham and Women's Hospital (BWH), Dana-Farber Cancer Institute (DFCI), Harvard Medical School (HMS), Massachusetts Institute of Technology (MIT), BIND Biosciences, Translational Genomics Research Institute (TGen), Wayne State University Karmanos Cancer Institute, and Weill Cornell Medical College have found promising effects of a first-in-class targeted cancer drug called BIND-014 in treating solid tumors.

BIND-014 is the first targeted and programmed nanomedicine to enter human clinical studies. The study will be electronically published in Science Translational Medicine on April 4, 2012.

In the study, the researchers demonstrate BIND-014's ability to effectively target a receptor expressed in tumors to achieve high tumor drug concentrations, as well as show remarkable efficacy, safety and pharmacological properties compared to the parent chemotherapeutic drug, docetaxel (Taxotere).

"BIND-014 demonstrates for the first time that it is possible to generate medicines with both targeted and programmable properties that can concentrate the therapeutic effect directly at the site of disease, potentially revolutionizing how complex diseases such as cancer are treated," said Omid Farokhzad, MD, a physician-scientist in the BWH Department of Anesthesiology, associate professor at HMS, and study co- senior author.

"Previous attempts to develop targeted nanoparticles have not successfully translated into human clinical studies because of the inherent difficulty of designing and scaling up a particle capable of targeting, long-circulation via immune-response evasion, and controlled drug release," said Robert Langer, ScD, David H. Koch Institute Professor, MIT and study co-senior author.

According to the researchers, the drug is the first of its kind to reach clinical evaluation and demonstrates a differentially high drug concentration in tumors by targe
'/>"/>

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. First Bedside Gene Test Shows Promise
2. Complications in patients undergoing PCI tend to occur within first 30 days
3. $4.2 million grant helps plan, launch first Alzheimers prevention trials
4. First national guideline for sudden hearing loss published
5. Researchers develop first theranostic treatment for acute lymphoblastic leukemia (ALL)
6. First study of its kind finds no increased risk of heart disease for kidney donors
7. UC San Diego among first in nation to treat brain cancer with novel viral vector
8. First breakdown of public health data for Cleveland neighborhoods
9. Rapid Flu Tests a Good First Step: Study
10. First study on long-term cognitive effects of breast cancer chemotherapy finds subtle impairment among women who received CMF regimen
11. Mount Sinai first to use visually guided catheter ablation system to treat AFib patient
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... NY (PRWEB) October 26, 2014 BioSkinLaser.Com, ... announces the most advanced and improved laser treatments for ... and safe treatments like the lip enhancement treatment ... keeping with specific focus areas of each customer. , ... cellulite reduction NYC . The company cited that ...
(Date:10/25/2014)... CA (PRWEB) October 25, 2014 More ... annual President’s Circle Reception on Monday at the home ... accomplishments and hear from guest speaker Dr. Winifred Lender ... worlds. , Dr. Lender, a Santa Barbara psychologist, author ... challenges and benefits of living in the digital age. ...
(Date:10/25/2014)... (PRWEB) October 25, 2014 ... Molecular Diagnostics Industry, 2009-2019 is a professional ... Chinese Molecular Diagnostics industry. The report firstly ... including its classification, application and manufacturing technology. ... top manufacturers of Molecular Diagnostics listing their ...
(Date:10/25/2014)... Mesothelioma researchers are reporting extended survival ... (Alimta), after his combination drug therapy became too toxic. ... just posted on the Surviving Mesothelioma website. , ... in Japan suggests that “maintenance therapy” with pemetrexed may ... cannot tolerate higher doses of cisplatin. , “Although ...
(Date:10/25/2014)... Not getting the right amount of sleep might raise ... Those who sleep less or more than the ... more prone to developing the chronic condition, which causes ... concluded that duration and quality of sleep are key ... diseases. "Both short and long durations of sleep ...
Breaking Medicine News(10 mins):Health News:BioSkinLaser.Com Now Offers Advanced Medical Aesthetics Procedures 2Health News:BioSkinLaser.Com Now Offers Advanced Medical Aesthetics Procedures 3Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 2Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 3Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 4Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 2Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 3Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 4Health News:New Report Illustrates Extended Mesothelioma Survival with “Maintenance Therapy”, According to Surviving Mesothelioma 2Health News:Sleep Duration Linked to Ulcerative Colitis Risk in Study 2
... flies. And it,s not just because they breed like ... and developmental biology by breeding and studying fruit flies (Drosophila ... important research animals because they reproduce quickly and, well, fruitfully; ... many genes and proteins with humans. Now there,s a ...
... study into Staphylococcus aureus , the bacterium which ... bacteria have developed a strategy of hiding within host ... many antibacterial treatments. The research, published by EMBO ... to adapt to their environmental conditions, lie dormant inside ...
... 700,000 for each of the 2011 prizes, of which CHF ... CHF 100,000 for their personal use. The prize ... be of considerable significance for medicine. Stefan Jentsch is ... his work on small protein modifiers and their role in ...
... , WEDNESDAY, Jan. 26 (HealthDay News) -- Screening ... higher in the United States among young black and ... explain why black and Hispanic women have higher reported ... Researchers who analyzed data from more than 40,000 visits ...
... conducted at Sahlgrenska University Hospital in Gothenburg and at ... of 18 and 65. Half the group was randomly ... half to maintain their usual lifestyle. Both groups ... group increased their physical activity on their own, but ...
... , TUESDAY, Jan. 25 (HealthDay News) -- Longevity isn,t increasing ... other developed countries, says a new report that points a ... 25 years, U.S. life expectancy at age 50 has increased, ... countries studied, including Japan and Australia, notes the report from ...
Cached Medicine News:Health News:Zebrafish popular with researchers 2Health News:Research shows how pathogenic bacteria hide inside host cells 2Health News:2011 Louis-Jeantet Prize for Medicine 2Health News:2011 Louis-Jeantet Prize for Medicine 3Health News:2011 Louis-Jeantet Prize for Medicine 4Health News:2011 Louis-Jeantet Prize for Medicine 5Health News:More Screenings May Explain Higher Chlamydia Rates Among Minorities 2Health News:Smoking, Obesity Slowing U.S. Life Expectancy Gains: Report 2Health News:Smoking, Obesity Slowing U.S. Life Expectancy Gains: Report 3
(Date:10/22/2014)...  With a vision to ensure safety and ... Pharmaceutical and Biotech manufacturer selects and implements the ... to protect their animal health brand.  ... Photo - http://photos.prnewswire.com/prnh/20141021/153439 ... by the Xyntek and Antares solution is an ...
(Date:10/22/2014)... CITY, Calif., Oct. 21, 2014 Abaxis, Inc. ... manufacturing point-of-care blood analysis systems, today reported financial results ... Second quarter overview: , Revenues of ... , Diluted EPS of $0.24, up 33% over ... , Service revenues from Abaxis Veterinary Reference Laboratories (AVRL) ...
(Date:10/22/2014)... NEW YORK , Oct. 22, 2014 ... an August 2014 report by Global Research & Data ... 6.2% per year from 2014 through 2018, as demand ... United States is the world,s largest market ... market with advanced thermometers is Sanomedics International Holdings, Inc. ...
Breaking Medicine Technology:Xyntek and Antares Serialization Solution Protects Pets Too! 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 4Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 5Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 6Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 7Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 8Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 9Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 10Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 11Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 12Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 13Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 14Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2
... California, 23 May 2007 - The antidepressant duloxetine,hydrochloride ... patients who did not respond, or responded only,partially, ... regardless of whether those patients were,switched from an ... was presented today at the American Psychiatric,Association’s 160 ...
... - ImmunoGen, Inc.,(Nasdaq: IMGN), a biopharmaceutical company that ... today announced that clinical findings for three,different TAP ... to be,reported at the 43rd American Society of ... 1-5, 2007 in Chicago, IL., Trastuzumab-DM1 (abstract #1042) ...
Cached Medicine Technology:In New Study, Duloxetine Was Equally Effective, Regardless of,Switch Method, in Reducing Painful Symptoms in Ssri Non- or,Partial-responders with Depression 2In New Study, Duloxetine Was Equally Effective, Regardless of,Switch Method, in Reducing Painful Symptoms in Ssri Non- or,Partial-responders with Depression 3In New Study, Duloxetine Was Equally Effective, Regardless of,Switch Method, in Reducing Painful Symptoms in Ssri Non- or,Partial-responders with Depression 4In New Study, Duloxetine Was Equally Effective, Regardless of,Switch Method, in Reducing Painful Symptoms in Ssri Non- or,Partial-responders with Depression 5In New Study, Duloxetine Was Equally Effective, Regardless of,Switch Method, in Reducing Painful Symptoms in Ssri Non- or,Partial-responders with Depression 6In New Study, Duloxetine Was Equally Effective, Regardless of,Switch Method, in Reducing Painful Symptoms in Ssri Non- or,Partial-responders with Depression 7In New Study, Duloxetine Was Equally Effective, Regardless of,Switch Method, in Reducing Painful Symptoms in Ssri Non- or,Partial-responders with Depression 8In New Study, Duloxetine Was Equally Effective, Regardless of,Switch Method, in Reducing Painful Symptoms in Ssri Non- or,Partial-responders with Depression 9ImmunoGen, Inc. Announces Clinical Findings for Three TAP Compounds,for Solid Tumors Are to be Reported at ASCO 2ImmunoGen, Inc. Announces Clinical Findings for Three TAP Compounds,for Solid Tumors Are to be Reported at ASCO 3
... Featuring an expanded database containing ... new identification cards, VITEK 2 Compact ... minimum amount of time (2 to ... majority of microorganisms that contaminate production ...
... Horizon Cardiology Hemo is a comprehensive ... for the cath lab. Patient ... cardiac images and procedural information all ... patient record, eliminating repetitive data entry. ...
... generation product is a patient monitoring system ... parameters, sensed at the tissue level, reflecting ... tissue by low power light and detects ... tissue. The light is guided to the ...
PowerMed is a billing software....
Medicine Products: