Navigation Links
First successful use of expanded umbilical-cord blood units to treat leukemia
Date:1/17/2010

ng their numbers. When given to a person, these cells can rapidly give rise to white blood cells and other components of the blood system," said Delaney, an assistant member in the Hutchinson Center's Clinical Research Division and an assistant professor in the Department of Pediatrics at the University of Washington School of Medicine

The stem cell expansion was possible by activating the Notch signaling pathway in the stem cells. This approach was developed by Irwin Bernstein, M.D., a member of the Hutchinson Center's Clinical Research Division, and was initially published in Nature Medicine in 2000. A decade of work ensued resulting in successful translation of the laboratory findings to patients in a clinical setting.

Delaney and colleagues built upon Bernstein's earlier work by engineering a protein that can be used in the lab to activate the Notch signaling pathway in stem cells and manipulate the cells in tissue culture to expand in quantity.

This successful laboratory method for expanding the number of stem/progenitor cells from a single unit of cord blood resulted in an average 164-fold increase in the number of CD34+ cells, a type of hematopoietic stem cell. Such cells are multipotent and give rise to all types of blood cells. Delaney said that a typical unit of cord blood usually contains less than 200,000 stem cells per kilogram of body weight of the recipient patient. In contrast, the expanded units contained on average 6 million CD34+ cells per kilogram of body weight, which is on par with conventional transplant sources.

The current study also describes the outcomes of 10 patients in an ongoing phase 1 clinical trial who received two units of cord blood to treat high-risk, acute leukemia. Each patient received one unit of non-manipulated cord blood and one in which the cells were expanded in the lab. Researchers evaluated the safety of infusing the expanded cells as well as how long it took to reconstitute the blood system,
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. First biomarker discovered that predicts prostate cancer outcome
2. FDA Approves First Anti-Psychotic for Kids
3. Single-incision belly-button surgery to remove kidney performed first at UT Southwestern
4. First study examines newly-licensed RN work attitudes and intentions
5. Glades General Hospital First in Palm Beach County to Provide On-Site Electronic Birth Registration
6. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
7. Father and Daughter From Tanzania Receive Their First Medical Examination in Newport Beach
8. High and mighty: first common height gene identified by researchers behind obesity gene finding
9. APA Comments on FDAs First Approval of Medication to Treat Pediatric Schizophrenia and Bipolar Disorder
10. TriWest Creates First-of-its-Kind Partnership to Offer Military Leaders With Grief Support Program
11. Watson Receives First FDA Approval for Manufacturing Product at Its Goa, India Facility
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... November 29, 2014 The holiday season is ... recently announced its new collection of fashionable party dresses. What’s ... off, on all these brand new outfits; the special offer ... is a renowned online supplier and it has received a ... new items are specially designed to flatter various body shapes; ...
(Date:11/28/2014)... 2014 Pathways Home Health & ... This national movement was created to encourage people to ... local charities and causes. This online event, celebrated ... kickoff of the holiday shopping season. #GivingTuesday is to ... Cyber Monday is to online commerce. , The goal ...
(Date:11/28/2014)... is always making changes to its infrastructure architecture as ... effective, and secure experience. Most recently, the company announced ... to setup local servers for each country or continent. ... the globe. , 2. The ability to setup a ... millions of users in one network. , 3. The ...
(Date:11/28/2014)... November 28, 2014 Junk-A-Car ( http://www.junkacar.com ... expanding their service offerings to help drivers, especially those ... and Washington, D.C. metropolitan areas deal with the especially ... a large part of the country. , With the ... in hundreds of totaled, crashed and junk ...
(Date:11/28/2014)... Novatus, a leading provider of contract ... provides customers with greater reporting capabilities, more searchable ... we continue to evolve and grow the Novatus ... improved performance in response to requests from our ... the enhancements that we have made to Advanced ...
Breaking Medicine News(10 mins):Health News:Trendy Party Dresses For The Coming Holiday Season From Balfleet.com 2Health News:Pathways Home Health & Hospice Joins #GivingTuesday; Annual Holiday Encourages Local Charitable Giving 2Health News:Pathways Home Health & Hospice Joins #GivingTuesday; Annual Holiday Encourages Local Charitable Giving 3Health News:Brosix Infrastructure Architecture Changes to Benefit Users 2Health News:Junk-A-Car Expanding Service to Assist U.S. Car Owners That May be Affected by Severe Winter Storms 2Health News:Novatus Releases v5.1 with New Advanced Reporting Capabilities 2
... Swedish medical university Karolinska Institutet have determined the first ... interaction between the mammalian egg coat and sperm. The ... glimpse into the molecular architecture of animal egg coats, ... medicine and the possibility of developing novel contraceptives. , ...
... skin, intestinal mucosa or blood, have a lifespan of only ... replenishment of specialized cells is indispensable. This is the task ... cells. , Stem cells have two main characteristics: ... cell types that make up their respective tissue a ...
... AARP CEO Bill Novelli today released the following statement in ... , , (Logo: http://www.newscom.com/cgi-bin/prnh/20070209/NYF043LOGO ... are in dire economic times that will only get worse ... immediate choice is between letting these corporations go under -- ...
... 4 Cardinal Health and the,Texas Hospital Association (THA) ... to safeguard patients and combat deadly health care associated,infections ... Texas Hospital Association and its marketing subsidiary, HealthShare,recently endorsed ... help combat HAIs, improve patient care and dramatically reduce,infection-related ...
... Getting back in the gym and,erasing years of ... amounts of,weight because your health depends on it is ... joining forces with NBC,s hit weight loss,program The ... of,their lives by creating a co-branded protein product, The ...
... Diagnostics, a segment of BD (Becton, Dickinson and Company) (NYSE: ... Food and Drug Administration (FDA) Premarket Approval (PMA) for the ... designed to enhance cervical cancer screening for cytology laboratories using ... squamous carcinoma, adenocarcinoma and their usual precursor conditions. ...
Cached Medicine News:Health News:Crystallography reveals the 3-D structure of mammalian sperm receptor 2Health News:Dormant stem cells for emergencies 2Health News:Dormant stem cells for emergencies 3Health News:AARP: Health Care and Pension Reform Critical to Economic Recovery 2Health News:AARP: Health Care and Pension Reform Critical to Economic Recovery 3Health News:Texas Hospital Association Endorses MedMined(TM) Services to Help Fight Hospital Acquired Infections 2Health News:Texas Hospital Association Endorses MedMined(TM) Services to Help Fight Hospital Acquired Infections 3Health News:DESIGNER WHEY to Help Contestants and Fans of NBC's The Biggest Loser Shed Pounds 2Health News:DESIGNER WHEY to Help Contestants and Fans of NBC's The Biggest Loser Shed Pounds 3Health News:DESIGNER WHEY to Help Contestants and Fans of NBC's The Biggest Loser Shed Pounds 4Health News:BD Receives FDA Approval for the BD FocalPoint(TM) GS Imaging System to Enhance the Detection of Cervical Cancer 2
(Date:11/26/2014)... Nov. 26, 2014  Cohen, Placitella & Roth, ... investors who purchased Nymox Pharmaceutical Corporation ("Nymox" or ... period from January 31, 2011 through November 2, ... and certain of its officers and directors publically ... of Sections 10(b) and 20(a) of the Securities ...
(Date:11/26/2014)... 2014   Regulus Therapeutics Inc . (NASDAQ: ... and development of innovative medicines targeting microRNAs, today announced ... CEO of Regulus, will present a company overview at ... at the New York Palace Hotel on Wednesday, December ... be webcast at the time of the presentation and ...
(Date:11/26/2014)... -- Investor-Edge has initiated coverage on the following ... PLC (NASDAQ: HZNP ), Endocyte Inc. (NASDAQ: ... ), and Theravance Inc. (NASDAQ: THRX ). Free ... http://investor-edge.com/register . On Tuesday, November 25, 2014, the ... Industrial Average edged 0.02% lower, to finish the day at ...
Breaking Medicine Technology:Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3Regulus to Present at the 26th Annual Piper Jaffray Healthcare Conference and Genetic Rx Conference 2Regulus to Present at the 26th Annual Piper Jaffray Healthcare Conference and Genetic Rx Conference 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5
... UBM Canon Medical Device Media Group,s ... the " Technological Advances in Implantable Devices " virtual event ... 5 p.m. Eastern.  The event is dedicated to cutting-edge trends ... conference and trade show offers the opportunity to learn from ...
... N.J., Feb. 1, 2011 Soligenix, Inc. (OTC Bulletin ... a late-stage biopharmaceutical company, announced today that it has ... and Chief Medical Officer. Dr. Horgan is a board-certified ... experience in the care of patients with inflammatory bowel ...
Cached Medicine Technology:UBM Studios Virtual Event Connects the UBM Canon Medical Device Media Group with the Medical Device Design Community 2UBM Studios Virtual Event Connects the UBM Canon Medical Device Media Group with the Medical Device Design Community 3Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 2Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 3Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 4
... a floor model centrifuge to do, but just ... PR-7000M delivers up to 50% more force in ... faster and more efficiently., Tremendous Capacity ... liters, PR-7000M accommodates 30 microplates, up to 408 ...
Inquire...
Inquire...
Inquire...
Medicine Products: