Navigation Links
First successful use of expanded umbilical-cord blood units to treat leukemia
Date:1/17/2010

SEATTLE Scientists at Fred Hutchinson Cancer Research Center have cleared a major technical hurdle to making umbilical-cord-blood transplants a more widely-used method for treating leukemia and other blood cancers.

In a study published in the Jan.17 edition of Nature Medicine, Colleen Delaney, M.D., and colleagues describe the first use of a method to vastly expand the number of stem/progenitor cells from a unit of cord blood in the laboratory that were then infused into patients resulting in successful and rapid engraftment.

The relatively small number of stem cells in cord blood units (about one-10th the number a patient receives from a conventional transplant) has been a reason that cord blood transplants take much longer to engraft than standard stem cell transplants from donors. The longer the engraftment takes, the higher the risk is that immunocompromised patients will acquire life-threatening infections because they have essentially no white blood cells to fight them.

Despite the numbers disadvantage, cord blood is a promising source of stem cells to replace diseased blood and immune systems in stem cell transplantation because the donated cells don't need to be perfectly matched to the patient. The lack of a suitable match is why about 30 percent of patients overall who need a stem cell transplant to treat cancers such as leukemia can't find suitable donors. Among racial-minority patients the number who cannot find suitable donors is about 95 percent.

The use of expanded cord blood cells could decrease the risk of early death, which is higher in patients receiving a cord-blood transplant without expanded cells. Further clinical trials and technological improvements are needed to verify the efficacy of cord blood transplants that use expanded cells, the authors said.

"The real ground-breaking aspect of this research is that we have shown that you can manipulate stem/progenitor cells in the lab with the goal of increasi
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. First biomarker discovered that predicts prostate cancer outcome
2. FDA Approves First Anti-Psychotic for Kids
3. Single-incision belly-button surgery to remove kidney performed first at UT Southwestern
4. First study examines newly-licensed RN work attitudes and intentions
5. Glades General Hospital First in Palm Beach County to Provide On-Site Electronic Birth Registration
6. UHW Announces: Antelope Valley Hospital Caregivers and Board Vote to Ratify First Union Contract With SEIU UHW-West
7. Father and Daughter From Tanzania Receive Their First Medical Examination in Newport Beach
8. High and mighty: first common height gene identified by researchers behind obesity gene finding
9. APA Comments on FDAs First Approval of Medication to Treat Pediatric Schizophrenia and Bipolar Disorder
10. TriWest Creates First-of-its-Kind Partnership to Offer Military Leaders With Grief Support Program
11. Watson Receives First FDA Approval for Manufacturing Product at Its Goa, India Facility
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... JZ Fitness, an independently operated wellness ... programming, authorship, international lecturing and community wellness, created by ... release of the JZ Fitness nutrition app, available on ... thousands of individuals on nutrition, Jenn Zerling (“JZ”) has ... require calorie counting or cumbersome food logging. ...
(Date:10/20/2014)... October 20, 2014 Myoderm ... as Assistant Director of their CentralSource ... managing the innovative turnkey drug sourcing, distribution, and ... brings over 12 years of industry experience, in ... at the peak of their international success to ...
(Date:10/20/2014)... OH (PRWEB) October 20, 2014 National Teen ... Chapter of the American Academy of Pediatrics (Ohio AAP, ... (NHTSA) in encouraging parents of teen drivers to talk to ... the road. , Motor vehicle crashes are the leading cause ... teen drivers involved in fatal crashes, and 859 (42%) of ...
(Date:10/20/2014)... Punzoné , the first line of ultra-premium ... lot to celebrate this month. October marks Italian Heritage Month ... contributions of Americans of Italian heritage and Italians in America. ... shares its favorite Italian cocktails and encourages everyone to enjoy ... if it is only in a glass. , Punzoné ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 The ... iPage ( http://www.top10bestseohosting.com/go/iPage/ ) and GreenGeeks are the ... excellent platforms for those who want to buy ... same time. , The IT manager of Top10BestSEOHosting.com ... the most recommended suppliers for everyone. A lot ...
Breaking Medicine News(10 mins):Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2
... CARLSBAD, Calif., Oct. 2 Isis,Pharmaceuticals, Inc. (Nasdaq: ... received,clearance under the Hart-Scott-Rodino Antitrust Improvements Act for ... company, which,was announced on September 13, 2007. ... to Ortho-McNeil,worldwide development and commercialization rights to two ...
... for a loved one with dementia, TUCSON, Ariz., ... a new book that aims to ease the challenges ... and,Families are Still Asking WHY?, author Jim Greenwood, whose ... and useful,advice on how to best care for a ...
... Recruitment Efforts for Pulmonary Study, SOLANA ... Solutions, LLC, a firm specializing in patient ... its team of Regional Recruitment,Specialists(TM) in support ... of,Chronic Obstructive Pulmonary Disease (COPD) for a ...
... for Massachusetts Firms, WASHINGTON, Oct. 1 ... bill with provisions secured by,Senator John Kerry (D-Mass.) ... through 2010 and to increase the transition and,commercialization ... will ensure that the thousands of firms that ...
... Amylin Pharmaceuticals,Inc. (Nasdaq: AMLN ) announced ... (FDA) has approved the SymlinPen(TM) 120 and ... acetate) injection. These new pre-filled pen-injector devices,feature ... control. "SymlinPen 120 and SymlinPen 60 ...
... any period of time after leaving the foster care ... than those with stable housing situations, according to a ... & Adolescent Medicine, one of the JAMA/Archives journals. Youth ... after leaving the foster care system appear to have ...
Cached Medicine News:Health News:Isis Announces HSR Approval and Closure of Its Collaboration With Ortho-McNeil, Inc. 2Health News:Alzheimer's Caregivers Get Sage Advice 2Health News:RESolutions Rapid Enrollment Solutions, LLC Mobilizes Team of Regional Recruitment Specialists(TM) 2Health News:Kerry Extends, Improves Small Business Innovation Program 2Health News:FDA Approves SYMLIN Pen-Injector Devices Offering Convenience and Accuracy for SYMLIN Use 2Health News:FDA Approves SYMLIN Pen-Injector Devices Offering Convenience and Accuracy for SYMLIN Use 3Health News:FDA Approves SYMLIN Pen-Injector Devices Offering Convenience and Accuracy for SYMLIN Use 4Health News:Poor health care access common among youth leaving foster system 2Health News:Poor health care access common among youth leaving foster system 3
(Date:10/20/2014)... 20, 2014 Pharmaceutic Labs announces the opening ... Albany, NY for admixing, compounding, drug ... and/or exceeds the FDA standards for safety and quality, ... 211. The 10,000 square foot outsourcing ... quality assurance and quality control. The company will produce ...
(Date:10/20/2014)... 20, 2014 Norgine B.V. today ... low volume bowel preparation, NER1006, presented at the 79 ... of Gastroenterology (ACG), Philadelphia, PA , ... weight and co-primary endpoint of cleansing success. The study ... MOVIPREP ® in screening colonoscopy patients. [1] ...
(Date:10/19/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) ... has notified the Board of Directors of his decision to step ... as CFO of Severn Trent plc.  James will leave Shire at ... search for a new CFO immediately. Flemming Ornskov, Shire,s ... lead a high-quality finance team at Shire. We are very grateful ...
Breaking Medicine Technology:Positive Results from Phase II Data Show NER1006 Achieves High Quality Bowel Cleansing Efficacy 2Interim Chief Financial Officer James Bowling to Step Down 2Interim Chief Financial Officer James Bowling to Step Down 3Interim Chief Financial Officer James Bowling to Step Down 4
... VISION is Guidant's first cobalt chromium stent ... MINI VISION to have remarkably thin struts ... creating a highly deliverable stent. Less metal, ... outcomes in small vessel treatment. The Guidant ...
... an ophthalmologic medical device designed for the ... to -3.00 diopters.* When placed in the ... optical zone, the product reshapes the anterior ... composed of two prescription inserts, each having ...
... Aerotels Heartline™ system is winning the hearts ... world. "Remaining calm are the operative words ... At the same time they and their ... to any change in their heart condition ...
... Weights offer the physician a new approach to ... paralysis. The weight simply uses gravity to gently ... down, or when the eyelid muscle is relaxed. ... a variety of skin tone colors to match ...
Medicine Products: